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CIC fusion-positive sarcoma of the spermatic cord

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Abstract

In addition to germ cell tumors and tumors of the sex cord stroma, the WHO classification of testis and paratesticular tumors also contains malignant soft tissue tumors. Among them, liposarcomas of the spermatic cord are the most common entities. Other mesenchymal tumors with smooth muscle, skeletal muscle, fibroblastic/myofibroblastic, or nerve sheath differentiation are rare. Ewing sarcoma is composed of uniform small round cells and typically characterized by translocations of the EWSR1 gene. In rare cases, Ewing sarcoma-like tumors lack an EWSR1 gene fusion. Some of these tumors harbor a specific CIC translocation. However, Ewing-like sarcoma has up to now never been described in the testis or spermatic cord. The present case describes the first EWSR1-negative, undifferentiated round cell sarcoma with CIC translocation of the spermatic cord. Potential differential diagnoses are discussed.

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Funding

FB is supported by the Wilhelm-Sander-Stiftung (2016.041.1).

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Authors and Affiliations

  1. Institute of Pathology, University Medical Center Göttingen, Robert-Koch-Str.40, 37075, Göttingen, Germany

    Felix Bremmer, Alexander Fichtner, Laura Lukat, Philipp Ströbel & Hans Ulrich Schildhaus

  2. Center for Pathology, Cytology and Molecular Pathology, Luise-Rainer-Str. 12, 40235, Düsseldorf, Germany

    Ralph Triefenbach & Reinhard Inniger

  3. Department of Urology, Catholic Clinics Oberberg, Wohlandstraße 30, 51766, Engelskirchen, Germany

    Peter Mayer

Authors
  1. Felix Bremmer
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  2. Alexander Fichtner
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  3. Ralph Triefenbach
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  4. Reinhard Inniger
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  5. Peter Mayer
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  6. Laura Lukat
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  7. Philipp Ströbel
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  8. Hans Ulrich Schildhaus
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Contributions

F.B. A.F., and P.S. were responsible design of the study, interpretation of the results, and writing the manuscript. L.L. and H.U.S. were responsible for FISH experiments. R.T., A.F., R.I. and F.B. contributed critical discussion of the experiments and results. F.B., A.F., P.S., and H.U.S. reviewed the manuscript.

Corresponding author

Correspondence to Felix Bremmer.

Ethics declarations

The case report was approved by the ethics committee of the University Medical Center Göttingen (applicant number: 7/2/18An). The patient gave his formal consent to the publication of the data.

Conflict of interest

The authors declare that they have no conflict of interest.

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Bremmer, F., Fichtner, A., Triefenbach, R. et al. CIC fusion-positive sarcoma of the spermatic cord. Virchows Arch 474, 253–257 (2019). https://doi.org/10.1007/s00428-018-2471-5

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  • DOI: https://doi.org/10.1007/s00428-018-2471-5

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