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Primary classic Hodgkin lymphoma of the ileum and Epstein-Barr virus mucocutaneous ulcer of the colon: two entities compared

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Abstract

Primary classic Hodgkin lymphoma of the gastrointestinal tract represents a rare occurrence. A full patient’s work-up is essential in order to exclude a secondary intestinal involvement. Histologically Epstein-Barr virus mucocutaneous ulcer closely resembles Hodgkin lymphoma. The differential diagnosis between these two entities is relevant, since both the therapeutic approach and the clinical behavior are different. Herein, we describe a case of primary classic Hodgkin lymphoma arising in the ileum and a case of Epstein-Barr virus mucocutaneous ulcer of the colon, focusing on the main clinicopathological differences.

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Acknowledgments

We would like to particularly thank Professor Elaine Jaffe for her important observations in the drafting of the paper.

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Authors and Affiliations

  1. Pathology Unit, Azienda Unità Sanitaria Locale/IRCCS, Reggio Emilia, Italy

    Magda Zanelli, Maria Cecilia Mengoli, Riccardo Valli, Elisabetta Froio, Alessandra Bisagni & Loredana De Marco

  2. Department of Oncology and Advanced Technologies, Surgical Oncology Unit, Azienda Unità Sanitaria Locale/IRCCS, Reggio Emilia, Italy

    Maurizio Zizzo

  3. Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy

    Maurizio Zizzo

  4. Pathology Unit, Ospedale di Terni, University of Perugia, Perugia, Italy

    Stefano Ascani

Authors
  1. Magda Zanelli
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  2. Maria Cecilia Mengoli
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  3. Riccardo Valli
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  4. Elisabetta Froio
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  5. Alessandra Bisagni
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  6. Maurizio Zizzo
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  7. Loredana De Marco
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  8. Stefano Ascani
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Contributions

MZ made the diagnosis of EBVRMCU and wrote the paper; MCM is the corresponding author and collected the medical history of the patients; RV reviewed the literature data and contributed to the discussion; EF took the photos and made the immunohistochemical analysis of the case of EBVRMCU; AB made the molecular investigations; MZ performed the surgical resections; LDM reviewed the literature data and contributed to the discussion; SA made the diagnosis of LH, took the photos, and made the immunohistochemical analysis of the case of LH. All the authors have reviewed and approved the final version of the manuscript.

Corresponding author

Correspondence to Maria Cecilia Mengoli.

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The authors declare that they have no conflict of interest.

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Zanelli, M., Mengoli, M.C., Valli, R. et al. Primary classic Hodgkin lymphoma of the ileum and Epstein-Barr virus mucocutaneous ulcer of the colon: two entities compared. Virchows Arch 474, 117–123 (2019). https://doi.org/10.1007/s00428-018-2451-9

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  • DOI: https://doi.org/10.1007/s00428-018-2451-9

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