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β-catenin (CTNNB1) mutation and LEF1 expression in sinonasal glomangiopericytoma (sinonasal-type hemangiopericytoma)

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Abstract

Sinonasal glomangiopericytoma (SN-GPC) is an uncommon mesenchymal tumor with myoid differentiation. Recently, mutations in exon 3 of the gene coding for β-catenin (CTNNB1) and its nuclear expression were discovered in SN-GPC. β-catenin protein is a key regulatory molecule of the canonical Wnt signaling pathway. The expression of β-catenin target proteins is not well characterized in SN-GPC. We examined three SN-GPCs by immunohistochemistry and CTNNB1 mutation analysis. All cases expressed nuclear β-catenin. We identified CTNNB1 exon 3 mutations in two analyzable cases. Lymphoid enhancer-binding factor 1 (LEF1), a protein downstream from β-catenin, was also expressed in all cases. Our results further characterized the activation of the Wnt signaling pathway caused by CTNNB1 exon 3 mutation and suggest the utility of LEF1 immunohistochemistry in the differential diagnosis of SN-GPC.

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Funding

This study was supported, in part, by a Grant-in-Aid for Clinical Research from the National Hospital Organization.

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Authors and Affiliations

  1. Department of Pathology and Clinical Laboratories, Nagoya University Hospital, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8560, Japan

    Yuka Suzuki, Yoshie Shimoyama, Shigeo Nakamura & Masato Nakaguro

  2. Department of Pathology, Nagoya Medical Center, Nagoya, Japan

    Shu Ichihara & Tomonori Kawasaki

  3. Department of Pathology, Okayama University Hospital, Okayama, Japan

    Hiroyuki Yanai

  4. Department of Pathology, Toyota Memorial Hospital, Toyota, Japan

    Satoshi Kitagawa

Authors
  1. Yuka Suzuki
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  2. Shu Ichihara
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  3. Tomonori Kawasaki
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  4. Hiroyuki Yanai
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  5. Satoshi Kitagawa
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  6. Yoshie Shimoyama
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  7. Shigeo Nakamura
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  8. Masato Nakaguro
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Corresponding author

Correspondence to Masato Nakaguro.

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The study was approved by the institutional review board.

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The authors declare that they have no conflict of interest.

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Suzuki, Y., Ichihara, S., Kawasaki, T. et al. β-catenin (CTNNB1) mutation and LEF1 expression in sinonasal glomangiopericytoma (sinonasal-type hemangiopericytoma). Virchows Arch 473, 235–239 (2018). https://doi.org/10.1007/s00428-018-2370-9

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  • DOI: https://doi.org/10.1007/s00428-018-2370-9

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