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Papillary-cystic pattern is characteristic in mammary analogue secretory carcinomas but is rarely observed in acinic cell carcinomas of the salivary gland

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Abstract

Mammary analogue secretory carcinoma (MASC) has a specific ETV6-NTRK3 translocation and morphologically overlaps with acinic cell carcinoma (AciCC). Before the recognition of MASC, in AciCC, four histologic patterns were identified including microcystic, solid, papillary-cystic, and follicular. The aim of this study was to evaluate histologic patterns in these two neoplasms through comprehensive histologic subtyping. Using fluorescence in situ hybridization (FISH), we identified 14 cases of MASC and 21 cases of AciCC. We used comprehensive histologic subtyping to provide a semiquantitive assessment of histologic patterns in each tumor and performed immunohistochemical analyses including S100/vimentin/mammaglobin/DOG1. MASC often presented papillary-cystic patterns without a solid component, previously considered to be one of the four major patterns associated with AciCC. However, in our study, this histologic feature was rarely seen in AciCC and more characteristic of MASC. In aspiration cytology samples, MASC was associated with more cellular atypia. An immunohistochemical panel of S100/mammaglobin/DOG1 was found useful for differential diagnosis. Comprehensive subtyping of histologic patterns is a useful screening method prior to initiation of molecular testing.

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Acknowledgments

The authors would like to thank Ms. Syue-Fong Hua for her technical support and the Department of Pathology at the National Taiwan University Hospital for providing laboratory facilities. This study was supported by grants from the National Taiwan University Hospital (103-002523) and the Far East Memorial Hospital (FEMH 2014-C-052).

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All authors have no potential conflict of interest to declare.

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Authors and Affiliations

  1. Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, No 7, Chung-Shan South Road, 100, Taipei, Taiwan

    Min-Shu Hsieh & Yih-Leong Chang

  2. Department of Pathology, Far East Memorial Hospital, New Taipei city, Taiwan

    Yueh-Hung Chou

  3. Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan

    Shin-Joe Yeh

Authors
  1. Min-Shu Hsieh
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  2. Yueh-Hung Chou
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  3. Shin-Joe Yeh
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  4. Yih-Leong Chang
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Correspondence to Yih-Leong Chang.

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Hsieh, MS., Chou, YH., Yeh, SJ. et al. Papillary-cystic pattern is characteristic in mammary analogue secretory carcinomas but is rarely observed in acinic cell carcinomas of the salivary gland. Virchows Arch 467, 145–153 (2015). https://doi.org/10.1007/s00428-015-1786-8

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  • DOI: https://doi.org/10.1007/s00428-015-1786-8

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