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Potentially clinically relevant prostate cancer is found more frequently after complete than after partial histopathological processing of radical cystoprostatectomy specimens

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Abstract

Incidental prostate cancer is often found in cystoprostatectomy specimens. The presence of a clinically significant tumour has an impact on follow-up strategies. In prostatectomy specimen for prostate cancer, whole-mount sections improve diagnostic accuracy. The present study compares detection of incidental prostate cancer in complete to routine processing. We included 295 consecutive patients who underwent radical cystoprostatectomy. Between 01/1995 and 12/2003 (period I), specimens of 129 patients were partially processed, whereas between 01/2004 and 03/2009 (period II), specimens of 166 patients were completely processed. Incidental prostate cancer was detected overall in 91 (30.8 %) patients. Prostate cancer was detected in 24 (18.6 %) patients in period 1 and in 67 (40.4 %) patients in period 2 (p < 0.001). Potentially clinically significant prostate cancer was detected in 12 (9.2 %) and 29 (17.5 %) patients, respectively (p = 0.044). Complete embedding and processing of cystoprostatectomy specimen yield significantly more potentially clinically relevant prostate cancers. The present data suggest that notably in younger men the specimens should be completely processed.

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Acknowledgments

We thank Patrick Goldsworthy for his excellent assistance.

Conflict of interest

None of the authors has any disclosure or conflict of interest.

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Authors and Affiliations

  1. Department of Urology, Caritas St. Josef Medical Centre, University of Regensburg, Landshuter Str. 65, 93053, Regensburg, Germany

    H. M. Fritsche, A. Aziz, W. Otto, S. Denzinger & W. F. Wieland

  2. Department of Pathology, University of Regensburg, Regensburg, Germany

    F. Eder & F. Hofstädter

  3. Department of Urology, St. Elisabeth-Hospital, Straubing, Germany

    M. May

  4. Department of Pathology, University of Erlangen, Erlangen, Germany

    A. Hartmann

  5. Department of Urology, University of Würzburg, Würzburg, Germany

    M. Burger

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  1. H. M. Fritsche
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  2. A. Aziz
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  3. F. Eder
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  4. W. Otto
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  7. M. May
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Correspondence to H. M. Fritsche.

Additional information

HM Fritsche and A Aziz contributed equally.

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Fritsche, H.M., Aziz, A., Eder, F. et al. Potentially clinically relevant prostate cancer is found more frequently after complete than after partial histopathological processing of radical cystoprostatectomy specimens. Virchows Arch 461, 655–661 (2012). https://doi.org/10.1007/s00428-012-1328-6

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  • DOI: https://doi.org/10.1007/s00428-012-1328-6

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