Skip to main content

Advertisement

SpringerLink
Log in

Iatrogenic EBV-positive lymphoproliferative disorder with features of EBV+ mucocutaneous ulcer: evidence for concomitant TCRγ/IGH rearrangements in the Hodgkin-like neoplastic cells

  • Case Report
  • Published:
Virchows Archiv Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

References

  1. Gaulard P, Swerdlow SH, Harris NL, Jaffe ES, Sundström C (2008) Other iatrogenic immunodeficiency-associated lymphoproliferative disorders. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (eds) WHO Classification of Tumours of Haematopoietic and Lymphoid tissues, 4th edn. International Agency for Research on Cancer, Lyon, PA, pp 350–351

    Google Scholar 

  2. Kamel OW, van de Rijn M, Weiss LM et al (1993) Brief report: reversible lymphomas associated with Epstein–Barr virus occurring during methotrexate therapy for rheumatoid arthritis and dermatomyositis. N Engl J Med 328:1317–1321

    Article  PubMed  CAS  Google Scholar 

  3. Ferraccioli GF, Casatta L, Bartoli E et al (1995) Epstein-Barr virus-associated Hodgkin’s lymphoma in a rheumatoid arthritis patient treated with methotrexate and cyclosporin A. Arthritis Rheum 38:867–868

    Article  PubMed  CAS  Google Scholar 

  4. Kamel OW, Weiss LM, van de Rijn M, Colby TV, Kingma DW, Jaffe ES (1996) Hodgkin’s disease and lymphoproliferations resembling Hodgkin’s disease in patients receiving long-term low-dose methotrexate therapy. Am J Surg Pathol 20:1279–1287

    Article  PubMed  CAS  Google Scholar 

  5. Dojcinov SD, Venkataraman G, Raffeld M, Pittaluga S, Jaffe ES (2010) EBV positive mucocutaneous ulcer—a study of 26 cases associated with various sources of immunosuppression. Am J Surg Pathol 34:405–417

    Article  PubMed  Google Scholar 

  6. van Dongen JJ, Langerak AW, Brüggemann M et al (2003) Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia 17:2257–2317

    Article  PubMed  Google Scholar 

  7. Nakamura S, Jaffe ES, Swerdlow SH (2008) EBV positive diffuse large B cell lymphoma of the eldery. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (eds) WHO Classification of Tumours of Haematopoietic and Lymphoid tissues, 4th edn. International Agency for Research on Cancer, Lyon PA, pp 243–244

    Google Scholar 

  8. Oyama T, Ichimura K, Suzuki R et al (2003) Senile EBV+ B-cell lymphoproliferative disorders: a clinicopathologic study of 22 patients. Am J Surg Pathol 27:16–26

    Article  PubMed  Google Scholar 

  9. Asano N, Yamamoto K, Tamaru J et al (2009) Age-related Epstein-Barr virus (EBV)-associated B-cell lymphoproliferative disorders: comparison with EBV-positive classic Hodgkin lymphoma in elderly patients. Blood 113:2629–2636

    Article  PubMed  CAS  Google Scholar 

  10. Szczepański T, Beishuizen A, Pongers-Willemse MJ et al (1999) Cross-lineage T cell receptor gene rearrangements occur in more than ninety percent of childhood precursor-B acute lymphoblastic leukemias: alternative PCR targets for detection of minimal residual disease. Leukemia 13:196–205

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

This work has been supported by funding from Università degli Studi di Roma “Sapienza”.

Conflict of interest

We declare that we have no conflict of interest.

Author information

Authors and Affiliations

  1. UOC Anatomia Patologica, Dipartimento di Medicina Clinica e Molecolare, Ospedale Sant’Andrea, II Facoltà di Medicina e Chirurgia, Università “Sapienza”, Rome, Italy

    Arianna Di Napoli, Maria Giubettini, Enrico Duranti, Stefania Uccini & Luigi Ruco

  2. UOC Ematologia, Dipartimento di Medicina Clinica e Molecolare, Ospedale Sant’Andrea, II Facoltà di Medicina e Chirurgia, Università “Sapienza”, Rome, Italy

    Antonella Ferrari & Cesare Guglielmi

  3. UOC Anatomia Patologica, Dipartimento di Medicina Clinica e Molecolare, II Facolta’ di Medicina e Chirurgia, Università degli Studi di Roma “Sapienza”, Ospedale Sant’Andrea, Via di Grottarossa 1035–1039, 00189, Rome, Italy

    Arianna Di Napoli

Authors
  1. Arianna Di Napoli
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Maria Giubettini
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Enrico Duranti
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Antonella Ferrari
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Cesare Guglielmi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Stefania Uccini
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Luigi Ruco
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Arianna Di Napoli.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Di Napoli, A., Giubettini, M., Duranti, E. et al. Iatrogenic EBV-positive lymphoproliferative disorder with features of EBV+ mucocutaneous ulcer: evidence for concomitant TCRγ/IGH rearrangements in the Hodgkin-like neoplastic cells. Virchows Arch 458, 631–636 (2011). https://doi.org/10.1007/s00428-011-1064-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00428-011-1064-3

Keywords

Search

Navigation