Abstract
Atypical lipomatous tumor or well-differentiated liposarcoma (ALT-WDLPS) and dedifferentiated liposarcoma (DDLPS) share the same basic genetic abnormality characterized by a simple genomic profile with a 12q14–15 amplification involving MDM2 gene. These tumors are the most frequent LPS. This paper reviews the molecular pathology, general clinical and imaging features, histopathology, new diagnostic tools, and prognosis of ALT-WDLPS and DDLPS.
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Coindre, JM., Pédeutour, F. & Aurias, A. Well-differentiated and dedifferentiated liposarcomas. Virchows Arch 456, 167–179 (2010). https://doi.org/10.1007/s00428-009-0815-x
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DOI: https://doi.org/10.1007/s00428-009-0815-x