Skip to main content

Advertisement

SpringerLink
Log in

Renal angiomyoadenomatous tumor: morphologic, immunohistochemical, and molecular genetic study of a distinct entity

  • Original Article
  • Published:
Virchows Archiv Aims and scope Submit manuscript

Abstract

We present a series of a distinct tumorous entity named renal angiomyoadenomatous tumor (RAT). Five cases were retrieved from the consultation files of the authors. Histologic and immunohistochemical features were evaluated. Sequencing analysis of coding region of the VHL gene was carried out in all cases. The tumors were composed of admixture of an epithelial clear cell component and prominent leiomyomatous stroma. Epithelial cells formed adenomatous tubular formations endowed with blister-like apical snouts. All tubular/glandular structures were lined by a fine capillary network. The epithelial component was positive for epithelial membrane antigen, CK7, CK20, AE1-AE3, CAM5.2, and vimentin in all cases. In all analyzed samples, no mutation of the VHL gene was found. RAT is a distinct morphologic entity, being different morphologically, immunohistochemically, and genetically from all renal tumors including conventional clear cell carcinoma and mixed epithelial and stromal tumor of kidney.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11

Similar content being viewed by others

References

  1. Adsay NV, Eble JN, Srigley JR, Jones EC, Grignon DJ (2000) Mixed epithelial and stromal tumor of the kidney. Am J Surg Pathol 24:958–970

    Article  PubMed  CAS  Google Scholar 

  2. Al-Ahmadie HA, Alden D, Qin L-X, Olgac S, Fine SW, Gopalan A, Russo P, Motzer RJ, Reuter VE, Tickoo ST (2008) Carbonic anhydrase IX expression in clear cel renal cell carcinoma. An immunohistochemical study comparing 2 antibodies. Am J Surg Pathol 32:377–382

    PubMed  Google Scholar 

  3. Avery AK, Beckstead J, Renshaw AA, Corless CL (2000) Use of antibodies to RCC and CD10 in the differential diagnosis of renal neoplasms. Am J Surg Pathol 24:203–210

    Article  PubMed  CAS  Google Scholar 

  4. Buritica C, Serrano M, Zuluaga A, Arrabal M, Regauer S, Nogales FF (2007) Mixed epithelial and stromal tumour of the kidney with luteinised ovarian stroma. J Clin Pathol 60:98–100

    Article  PubMed  CAS  Google Scholar 

  5. Canzonieri V, Volpe R, Gloghini A, Carbone A, Merlo A (1993) Mixed renal tumor with carcinomatous and fibroleiomyomatous components, associated with angiomyolipoma in the same kidney. Pathol Res Pract 189:951–956

    PubMed  CAS  Google Scholar 

  6. Gobbo S, Eble JN, Grignon DJ, Martignoni G, MacLennan GT, Shah RB, Zhang S, Brunelli M, Ceng L (2008) Clear cell papillary renal cell carcinoma. A distinct histopathologic and molecular genetic entity. Am J Surg Pathol 32:1239–1245

    PubMed  Google Scholar 

  7. Govaerts JJL, van Gooswilligen JC, Vooys GP, Ramaekers FC, Herman CJ, Debruyne FM (1987) Renal hamartoma associated with renal cell (Grawitz) tumor. Eur Urol 13:276–280

    PubMed  CAS  Google Scholar 

  8. Hes O, Michal M, Šulc M, Kočová L, Hora M, Roušarová M (1998) Glassy hyaline globules in granular cell carcinoma, chromophobe cell carcinoma and oncocytoma renal tumors. Anna Diagn Pathol 2:12–18

    Article  CAS  Google Scholar 

  9. Hes O, Benákova K, Vaněček T, Šíma R, Michal M (2005) Clear cell type of renal cell carcinoma with numerous hyaline globules: A diagnostic pitfall. Pathol Intern 55:150–154

    Article  Google Scholar 

  10. Hes O, Hora M, Vaněček T, Šulc M, Havlíček F, Michal M (2003) Conventional renal cell carcinoma with granulomatous reaction. A report of three cases. Virchows Archiv 443:220–221

    Article  PubMed  Google Scholar 

  11. Honey RJ, Honey RM (1977) Tuberous sclerosis and bilateral renal carcinoma. Br J Urol 49:441–446

    Article  PubMed  CAS  Google Scholar 

  12. Kuhn E, De Anda J, Manoni S, Netto G, Rosai J (2006) Renal cell carcinoma associated with prominent angioleiomyoma-like proliferation. Report of 5 cases and review of the literature. Am J Surg Pathol 30:1372–1381

    Article  PubMed  Google Scholar 

  13. Madewell JE, Goldman SM, Davis CJ, Hartman DS, Feigin DS, Lichtenstein JE (1983) Multilocular cystic nephroma. A radiographic-pathologic correlation of 58 patients. Radiology 146:309–321

    PubMed  CAS  Google Scholar 

  14. Michal M, Syrůček M (1998) Benign mixed epithelial and stromal tumour of the kidney. Pathol Res Pract 194:445–448

    PubMed  CAS  Google Scholar 

  15. Michal M (2000) Benign mixed epithelial and stromal tumor of the kidney. Pathol Res Pract 196:275–276

    PubMed  CAS  Google Scholar 

  16. Michal M, Hes O, Bisceglia M, Simpson RW, Spagnolo DV, Parma A, Boudová L, Zachoval R, Suster S (2004) Mixed epithelial and stromal tumors of the kidney. A report of 22 cases. Virchows Archiv 445:359–367

    Article  PubMed  Google Scholar 

  17. Michal M, Vaněček T, Šíma R, Mukenšnabl P, Boudová L, Broučková M (2004) Primary capillary hemangioblastoma of peripheral soft tissues. Am J Surg Pathol 28:962–966

    Article  PubMed  Google Scholar 

  18. Michal M, Hes O, Havlíček F (2000) Benign renal angiomyoadenomatous tumor: A previously unreported renal tumor. Annals Diagn Pathol 4:311–315

    Article  CAS  Google Scholar 

  19. Murphy WM, Grignon DJ, Perlman EJ (2004) AFIP atlas of tumor pathology (fourth series). Tumors of the kidney, bladder, and related urinary structures. American Registry of Pathology, Washington DC (Figure 2–175, 187 pp)

    Google Scholar 

  20. Švec A, Hes O, Michal M, Zachoval R (2001) Malignant mixed epithelial and stromal tumor of the kidney. Virchows Arch 439:700–702

    PubMed  Google Scholar 

  21. Tu JJ, Chen Y-T, Hyjek E, Tickoo SK (2005) Carbonic anhydrase IX as a highly sensitive and specific marker of clear cell renal cell carcinoma: a comparative immunohistochemical study using a panel of commonly utilized antibodies in the differential diagnosis of renal cell tumors. Modern Pathol 18(suppl 1):169A

    Google Scholar 

  22. Widéhn S, Kindblom LG (1988) A rapid and simple method for electron microscopy of paraffin-embedded tissue. Ultrastruct Pathol 12:131–136

    Article  PubMed  Google Scholar 

  23. Yang Y, Hes O, Lanjing Z, Min L, Jian L, Min L, Hua W, Jie Z, Michal M (2005) Mixed epithelial and stromal tumor of the kidney with intestinal differentiation. A case report. Virchows Archiv 447:669–671

    Article  PubMed  Google Scholar 

Download references

Acknowledgment

The authors are grateful to Dr. Petr Mukensnabl for preparing excellent microscopical figures. This study was supported by grant IGA 9722-4

Author information

Authors and Affiliations

  1. Department of Pathology, Charles University, Faculty Hospital, Plzen, Czech Republic

    M. Michal, O. Hes, J. Nemcova, R. Sima & D. V. Kazakov

  2. Department of Urology, Charles University, Faculty Hospital, Plzen, Czech Republic

    M. Hora

  3. Red Cross Hospital Kochi, Kochi, Japan

    N. Kuroda

  4. Department of Pathology, Kansai Medical University Hirakata Hospital, Osaka, Japan

    N. Sakaida & C. Ohe

  5. University Hospital Dubrava, Zagreb, Croatia

    S. Bulimbasic

  6. EPM/UNIFESP, Sao Paulo, Brazil

    M. Franco

  7. Cytopathos s.r.o., Bratislava, Slovakia

    D. Danis

  8. Sikl’s Department of Pathology, Laboratore Spec. Diagnostiky Medical Faculty Hospital, Charles University, Alej Svobody 80, 304 60, Plzen, Czech Republic

    M. Michal

Authors
  1. M. Michal
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O. Hes
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Nemcova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. Sima
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. N. Kuroda
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. S. Bulimbasic
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. M. Franco
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. N. Sakaida
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. D. Danis
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. D. V. Kazakov
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. C. Ohe
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. M. Hora
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. Michal.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Michal, M., Hes, O., Nemcova, J. et al. Renal angiomyoadenomatous tumor: morphologic, immunohistochemical, and molecular genetic study of a distinct entity. Virchows Arch 454, 89–99 (2009). https://doi.org/10.1007/s00428-008-0697-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00428-008-0697-3

Keywords

Search

Navigation