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Caveolin-1 immuno-expression in human gastric cancer: histopathogenetic hypotheses

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Abstract

The immunohistochemical expression of caveolin-1 (cav-1) was evaluated in a series of gastric carcinomas (GC) and in the adjacent normal gastric mucosa. Cav-1 immuno-expression was found in most GC (94%) with a significantly higher amount in the Lauren intestinal type in comparison to the diffuse-type carcinomas. Interestingly, gastric intestinal metaplasia as well as the cells at the base and neck of gastric pits within all fundic mucosal fragments showed an evident cav-1 immuno-staining, suggesting a histogenetic derivation of these lesions from the trans-differentiation of chief cells or from a cryptic progenitor population at the base of fundic glands, as recently hypothesized by other authors. The absence of significant correlations between cav-1 immuno-expression and the other clinico-pathological parameters, such as the stage of disease or the patients overall survival, indicates that the role of cav-1 in GC is neither stage-specific nor related to prognosis.

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We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Human Pathology, University of Messina, Messina, Italy

    V. Barresi, G. Giuffre’, E. Vitarelli, P. Todaro & G. Tuccari

  2. Department of Human Pathology, Policlinico Universitario G. Martino, Pad D, Via Consolare Valeria, 98125, Messina, Italy

    V. Barresi

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  1. V. Barresi
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  2. G. Giuffre’
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  4. P. Todaro
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Correspondence to V. Barresi.

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Barresi, V., Giuffre’, G., Vitarelli, E. et al. Caveolin-1 immuno-expression in human gastric cancer: histopathogenetic hypotheses. Virchows Arch 453, 571–578 (2008). https://doi.org/10.1007/s00428-008-0681-y

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  • DOI: https://doi.org/10.1007/s00428-008-0681-y

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