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Prognostic significance of the Fas-receptor/Fas-ligand system in cervical squamous cell carcinoma

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Abstract

We studied whether Fas-receptor (Fas-R; CD95) expression, single-nucleotide polymorphisms (SNPs) in the Fas promoter region, and/or Fas-ligand (Fas-L) production could determine individual susceptibility to cervical cancer progression. The clinicopathologic features of 38 patients with cervical squamous carcinomas (22 stage I, 8 stage II, and 8 stage III+) were reviewed and related with: (a) Fas-R expression by immunohistochemistry; (b) Fas-R SNPs at -670 and -1377 locations by restriction fragment length polymorphism and DNA sequencing; and (c) Fas-L expression by immunohistochemistry. Overall and disease-free survival curves showed significant differences in relation to stage (p < 0.001). Fas-R was identified in 20 of 38 (52.6%) tumors without statistical differences in survival, stage, or Fas-L overproduction. Fas-R GG genotype was more common than expected in advanced tumors (p = 0.065). The Fas-R-1377A allele and AA genotype were unrelated with survival, stage, or Fas-R expression. Fas-L overproduction was detected in 20 of 38 (52.6%) tumors; it was more frequent in advanced-stage tumors and was inversely related to survival (p = 0.03) and decrease in host inflammatory response (p = 0.01). Fas-R expression by tumor cells seems unrelated to stage or lymphoid infiltrate. Tumor production of Fas-L may represent an attempt to destroy the host’s lymphocytic reaction.

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Authors and Affiliations

  1. Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Avda. Sant Antoni Ma Claret 167, 08025, Barcelona, Spain

    Enrique Lerma, Marisa Romero, Alberto Gallardo, Cristina Pons, Josefina Muñoz, Josefina Fuentes, Belen Lloveras, Lluis Catasus & Jaime Prat

  2. Department of Pathology, Bellvitge Hospital, Barcelona, Spain

    Belen Lloveras

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  1. Enrique Lerma
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  2. Marisa Romero
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  3. Alberto Gallardo
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Correspondence to Enrique Lerma.

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Lerma, E., Romero, M., Gallardo, A. et al. Prognostic significance of the Fas-receptor/Fas-ligand system in cervical squamous cell carcinoma. Virchows Arch 452, 65–74 (2008). https://doi.org/10.1007/s00428-007-0535-z

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  • DOI: https://doi.org/10.1007/s00428-007-0535-z

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