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Primary clear cell meningioma of the orbit mimicking a metastatic carcinoma: usefulness of immunohistochemistry and cytogenetic analysis

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Abstract

Clear cell meningiomas (CCM) are rare tumors of the nervous system that usually occur in young patients and display high recurrence rates and potentially aggressive behavior. In this report, we describe a primary CCM of the orbit in an 84-year-old man with a previous history of a clear cell carcinoma of the kidney. Histologically, the tumor demonstrated a sheet-like proliferation of clear polygonal cells. Differential diagnosis includes metastasis of clear cell carcinomas. Immunohistochemistry, by showing that tumor cells expressed vimentin, epithelial membrane antigen, and progesterone antigens, and cytogenetic analysis, by identifying a monosomy 22, confirmed the diagnosis of CCM.

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References

  1. Boulos PT, Dumont AS, Mandell JW, Jane JA Sr. (2001) Meningiomas of the orbit: contemporary considerations. Neurosurg Focus 10:1–10

    Article  Google Scholar 

  2. Carlotti CG Jr., Neder L, Colli BO, dos Santos MB, Garcia AS, Elias J Jr, Chimelli LC (2003) Clear cell meningioma of the fourth ventricle. Am J Surg Pathol 27:131–135

    Article  PubMed  Google Scholar 

  3. Dhall SS, Tumialan LM, Brat DJ, Barrow DL (2005) Spinal intradural clear cell meningioma following resection of a suprasellar clear cell meningioma. Case report and recommendations for management. J Neurosurg 103:559–563

    PubMed  Google Scholar 

  4. Epstein NE, Drexler S, Schneider J (2005) Clear cell meningioma of the cauda equina in an adult: case report and literature review. J Spinal Disord Tech 18:539–543

    Article  PubMed  Google Scholar 

  5. Goldberg RA, Rottman J, Cline RA (1990) Tumors metastatic to the orbit: a changing picture. Surv Ophthalmol 35:1–24

    Article  PubMed  CAS  Google Scholar 

  6. Hartmann C, Sieberns J, Gehlhar C, Simon M, Paulus W, von Deimling A (2006) NF2 mutations in secretory and other rare variants of meningiomas. Brain Pathol 16:15–19

    Article  PubMed  CAS  Google Scholar 

  7. Henderson JW (1994) Orbital tumors, 3rd edn. Raven, New York

    Google Scholar 

  8. Inoue T, Miyamoto K, Kodama H, Hosoe H, Shimokawa K, Shimizu K (2005) Cervical clear cell meningioma mimicking a vertebral metastasis. J Clin Neurosci 12:685–687

    Article  PubMed  Google Scholar 

  9. ISCN (2005) An international system for human cytogenetic nomenclature. In: Shaffer LG, Tommerup N (eds) S. Karger, Basel 2005

  10. Jain D, Sharma MC, Sarkar C, Suri V, Garg A, Singh M, Sharma BS, Mahapatra AK (2007) Clear cell meningioma, an uncommon variant of meningioma: a clinicopathologic study of nine cases. J Neurooncol 81:315–321

    Article  PubMed  CAS  Google Scholar 

  11. Kim Y-J, Ketter R, Henn W, Zang KD, Steudel W-I, Feiden W (2006) Histopathologic indicators of recurrence in meningiomas: correlation with clinical and genetic parameters. Virchows Arch 449:529–538

    Article  PubMed  CAS  Google Scholar 

  12. Kleihues P, Cavenee WK (eds) (2000) Pathology and genetics of tumours of the nervous system. IARC Press, Lyon, pp 176–184

  13. Limon J, Dal Cin P, Sandberg AA (1986) Application of long-term collagenase disaggregation for the cytogenetic analysis of human solid tumors. Cancer Genet Cytogenet 23:305–313

    Article  PubMed  CAS  Google Scholar 

  14. Liu PI, Liu GC, Tsai KB, Lin CL, Hsu JS (2005) Intraspinal clear-cell meningioma: case report and review of literature. Surg Neurol 63:285–288

    Article  PubMed  Google Scholar 

  15. Ming-Tak Ho D, Hsu C-Y, Ting L-T, Chiang H (2002) Histopathology and MIB-1 labeling index predicted recurrence of meningiomas. Cancer 94:1538–1547

    Article  Google Scholar 

  16. Oviedo A, Pang D, Zovickian J, Smith M (2005) Clear cell meningioma: case report and review of the literature. Pediatr Dev Pathol 8:386–390

    Article  PubMed  Google Scholar 

  17. Payano M, Kondo Y, Kashima K, Daa T, Yatsuka T, Kida H, Nakayama I, Yokoyama S (2004) Two cases of nondura-based clear cell meningioma of the cauda equina. APMIS 112:141–147

    Article  PubMed  Google Scholar 

  18. Prinz M, Patt S, Mitrovics T, Cervos-Navarro J (1996) Clear cell meningioma: report of a spinal case. Gen Diagn Pathol 141:261–267

    PubMed  CAS  Google Scholar 

  19. Ragel BT, Jensen RL (2005) Molecular genetics of meningiomas. Neurosurg Focus 19:1–8

    Article  Google Scholar 

  20. Riemenschneider MJ, Perry A, Reifenberger G (2006) Histological classification and molecular genetics of meningiomas. Lancet Neurol 5:1045–1054

    Article  PubMed  CAS  Google Scholar 

  21. Roser F, Nakamura M, Jacobs C, Vorkapic P, Samii M (2005) Sphenoid wing meningiomas with osseous involvement. Surgical Neurol 64:37–43

    Article  Google Scholar 

  22. Shields JA, Shields CL, Scartozzi R (2004) Survey of 1264 patients with orbital tumors and simulating lesions. Ophtalmology 111:997–1008

    Article  Google Scholar 

  23. Schneider BF, Shashi V, von Kap-Herr C, Golden WL (1995) Loss of chromosomes 22 and 14 in the malignant progession of meningiomas. A comparative study of fluorescence in situ hybridization (FISH) and standard cytogenetic analysis

  24. Teo JG, Goh KY, Rosenblum MK, Muszynski CA, Epstein FJ (1998) Intraparenchymal clear cell meningioma of the brainstem in a 2-year-old child. Case report and literature review. Pediatr Neurosurg 28:27–30

    Article  PubMed  CAS  Google Scholar 

  25. Vural M, Arslantas A, Ciftci E, Artan S, Atasoy MA (2007) An unusual case of cervical clear-cell meningioma in pediatric age. Childs Nerv Syst 23:225–229

    Article  PubMed  Google Scholar 

  26. Warraich I, Dunn DM, Oliver JW (2006) Solitary fibrous tumor of the orbit with epithelioid features. Arch Pathol Lab Med 130:1039–1041

    PubMed  Google Scholar 

  27. Zorludemir S, Scheithauer BW, Hirose T, Van Houten C, Miller G, Meyer FB (1995) Clear cell meningioma. A clinicopathologic study of a potentially aggressive variant of meningioma. Am J Surg Pathol 19:493–505

    Article  PubMed  CAS  Google Scholar 

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Acknowledgment

The authors thank Rita Attias for her skilfull technical assistance and Dr. Ellen Van Obberghen-Schilling for editing this manuscript. This work was supported by a grant from the Comité des Alpes-Maritimes de la Ligue Nationale contre le Cancer.

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Authors and Affiliations

  1. Laboratory of Clinical and Experimental Pathology, Louis Pasteur Hospital, 30 avenue de la voie romaine, 06002, Nice, France

    Maxime Benchetritt, Véronique Hofman, Elodie Long & Paul Hofman

  2. Department of Otorhinolaryngology, Louis Pasteur Hospital, 30 avenue de la voie romaine, 06002, Nice, France

    Guillaume Odin

  3. Laboratory of Solid Tumors Genetics, Faculty of Medicine, Centre Hospitalier Universitaire de Nice and CNRS UMR, 6543, Nice, France

    Elodie Basc & Florence Pedeutour

  4. Department of Pathology, Albert Michallon Hospital, 38043, Grenoble, France

    Basile Pasquier

  5. Human Biobank CHU-CAL-UNSA/CRB INSERM, Louis Pasteur Hospital, Nice, France

    Paul Hofman

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  1. Maxime Benchetritt
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  2. Véronique Hofman
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  3. Elodie Long
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  4. Guillaume Odin
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  5. Elodie Basc
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  6. Basile Pasquier
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  7. Florence Pedeutour
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  8. Paul Hofman
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Correspondence to Paul Hofman.

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Benchetritt, M., Hofman, V., Long, E. et al. Primary clear cell meningioma of the orbit mimicking a metastatic carcinoma: usefulness of immunohistochemistry and cytogenetic analysis. Virchows Arch 452, 209–213 (2008). https://doi.org/10.1007/s00428-007-0519-z

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  • DOI: https://doi.org/10.1007/s00428-007-0519-z

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