Abstract
Jo-1 syndrome is an autoimmune disease with autoantibodies against the histidyl tRNA synthetase. Characteristic clinical findings include inflammatory myopathy and interstitial lung disease. We present the first case of a patient with Jo-1 syndrome (positive Jo-1 autoantibodies, myositis, interstitial alveolitis) who developed Hodgkin’s lymphoma of nodular-sclerosing type. Thus, patients with Jo-1 syndrome and immunosuppressive therapy similar to other patients with autoimmune disease are at risk to develop lymphomas and should therefore be monitored carefully.
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Acknowledgments
We thank Prof. Hans H. Schild, director of the Department of Radiology, University of Bonn, for providing the CT scan image.
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Adam, A.C., Grohé, C., Stier, S. et al. Hodgkin’s lymphoma in a patient with Jo-1 syndrome. Virchows Arch 451, 101–104 (2007). https://doi.org/10.1007/s00428-007-0429-0
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DOI: https://doi.org/10.1007/s00428-007-0429-0