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Histological risk markers for non-cardia early gastric cancer

Pattern of mucin expression and gastric cancer

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Abstract

There are limited data regarding the prognostic value of the pattern of mucin expression in IM. To examine the role of the type of IM and pattern of mucin expression in IM as histological risk markers of gastric cancer, 80 patients with a history of endoscopic mucosal resection (EMR) for early gastric cancer and 80 sex and age-matched controls were studied. Serum levels of pepsinogen (PG) were measured by RIA, and MUC2, MUC5AC and MUC6 were evaluated immunohistochemically. There is a significant association between types of IM and atrophic scores or PG levels. The most incomplete IM (type II and III) preserving gastric mucin is the gastric and intestinal mixed (GI) type, whereas the complete type is the intestinal (I) type especially in the corpus lesser curve. Gastric cancer was most significantly associated with incomplete IM in the corpus lesser curve (OR=6.4; 95% CI, 2.0–21, p=0.002). Asynchronous multiple lesions were associated with incomplete IM in the corpus greater curve (OR=4.8; 95% CI, 1.4–16, p=0.01). Classification of IM obtained using fixed-point biopsy samples may enhance the ability of surveillance programs to detect patients at increased risk of gastric cancer.

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Acknowledgements

The authors thank all the laboratory technicians in the Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases for the expert technical assistance.

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Authors and Affiliations

  1. Department of Internal Medicine, Kawasaki Medical School, Okayama, Japan

    Akiko Shiotani & Ken Haruma

  2. Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan

    Noriya Uedo, Hiroyasu Iishi, Ryu Ishihara & Masaharu Tatsuta

  3. Department of Medicine, Aishinkai Nakae Hospital, Wakayama, Japan

    Mitutaka Kumamoto & Yukinori Nakae

  4. Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan

    Shingo Ishiguro

  5. Department of Medicine, VA Medical Center and Baylor College of Medicine, Houston, TX, USA

    David Y. Graham

  6. 577 Matsushima, Kurashiki, Okayama Prefecture, 701-0192, Japan

    Akiko Shiotani

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  1. Akiko Shiotani
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  2. Ken Haruma
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  3. Noriya Uedo
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  4. Hiroyasu Iishi
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  10. David Y. Graham
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Correspondence to Akiko Shiotani.

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Shiotani, A., Haruma, K., Uedo, N. et al. Histological risk markers for non-cardia early gastric cancer. Virchows Arch 449, 652–659 (2006). https://doi.org/10.1007/s00428-006-0300-8

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  • DOI: https://doi.org/10.1007/s00428-006-0300-8

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