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The expression of metaloproteinases-2 and -9 is different according to the patterns of growth and invasion in squamous cell carcinoma of the penis

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Abstract

Squamous cell carcinoma (SCC) of the penis is characterized by different patterns of growth and local invasion. The matrix metalloproteinases (MMPs) is a family of proteolytic enzymes that are involved in the degradation of extracellular matrix to allow the migration of tumor cells. The present study examined whether the expression of MMP-2 and -9 is correlated with the patterns of tumor growth and invasion in penile SCC. The expression of MMP-2 and -9 was examined immunohistochemically in samples of 115 patients. The cases were divided in three groups according to the patterns of growth and invasion: group 1, exophytic growth and pushing pattern of invasion; group 2, endophytic growth and invasion in large sheets of cells; and group 3, endophytic growth and invasion in small group or isolated cells. Tumors with MMP-2 and -9 overexpression are deeply invasive and present an invasion pattern of small groups of cells. Also, expression of MMP-2 changed from membrane to cytoplasm in invasive tumors, maybe representing activation of MMP-2. These findings allow us to conclude that the less differentiated tumors, which are more invasive and with a pattern of invasion in small group of cells, are associated with the overexpression of MMPs.

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Acknowledgements

The authors would like to acknowledge Mr. Renato Soares for the English grammar review, and Mr. Carlos Ferreira Nascimento and Mr. Severino Ferreira for their technical assistance.

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Authors and Affiliations

  1. Department of Anatomic Pathology, Medical and Research Center Hospital do Câncer A C Camargo, #211 Antonio Prudente Street, 1st floor, São Paulo, São Paulo, 01509-010, Brazil

    Fernando A. Soares, Isabela Werneck da Cunha & Sueli Nonogaki

  2. Department of Pelvic Surgery, Medical and Research Center Hospital do Câncer A C Camargo, #211 Antonio Prudente Street, 1st floor, São Paulo, São Paulo, 01509-010, Brazil

    Gustavo Cardoso Guimarães, Rodrigo Sousa Madeira Campos & Ademar Lopes

Authors
  1. Fernando A. Soares
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  2. Isabela Werneck da Cunha
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  3. Gustavo Cardoso Guimarães
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  4. Sueli Nonogaki
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  5. Rodrigo Sousa Madeira Campos
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  6. Ademar Lopes
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Correspondence to Fernando A. Soares.

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Soares, F.A., da Cunha, I.W., Guimarães, G.C. et al. The expression of metaloproteinases-2 and -9 is different according to the patterns of growth and invasion in squamous cell carcinoma of the penis. Virchows Arch 449, 637–646 (2006). https://doi.org/10.1007/s00428-006-0299-x

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  • DOI: https://doi.org/10.1007/s00428-006-0299-x

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