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Secretagogin, a novel neuroendocrine marker, has a distinct expression pattern from chromogranin A

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Abstract

Preliminary data suggest that secretagogin (SCGN), a calcium-binding protein identified from our previous proteomics study of colorectal cancers, is a potentially useful neuroendocrine marker. In this study, we further analyzed SCGN expression in normal and tumor tissues from various organ sites compared with three other conventional neuroendocrine markers [chromogranin A (CgA), neuron specific enolase, and synaptophysin]. We found strong SCGN staining in most normal neuroendocrine tissues except in the adrenal cortex. SCGN expression was identified in 140 out of 213 neuroendocrine tumors and 12 conventional carcinomas with neuroendocrine differentiation. In a subset of neuroendocrine tumors, such as gastric neuroendocrine cancers and typical carcinoid tumors of rectum and ovary, SCGN showed strong staining while CgA expression was often negative. It is intriguing to note that SCGN staining was positive in 26 out of 31 small cell lung cancers, more frequently than the other three markers. We conclude that SCGN is a novel neuroendocrine marker that may be useful in routine surgical pathology practice.

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Acknowledgements

This manuscript was supported by the Key Foundation from Zhejiang Science and Technology Bureau, China. We thank Professor Ludwig Wagner, University of Vienna, Austria, for providing the polyclonal antibody for SCGN. We are indebted to Dr. Peiguo Chou and Dr. Qing Huang, Department of Pathology, City of Hope National Medical Center, USA, for their kindness in providing several cases of soft tissue tumors, Merkel cell cancers, and extra-lung small cell cancers. We also thank Ms Min Wang for her technical support.

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Authors and Affiliations

  1. Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Zhejiang, China

    Maode Lai, Bingjian Lü, Xiaoming Xing, Enping Xu & Qiong Huang

  2. Department of Surgical Pathology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, China

    Guoping Ren

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  1. Maode Lai
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  2. Bingjian Lü
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Correspondence to Maode Lai.

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Lai, M., Lü, B., Xing, X. et al. Secretagogin, a novel neuroendocrine marker, has a distinct expression pattern from chromogranin A. Virchows Arch 449, 402–409 (2006). https://doi.org/10.1007/s00428-006-0263-9

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  • DOI: https://doi.org/10.1007/s00428-006-0263-9

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