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Diagnosis of primary esophageal synovial sarcoma by demonstration of t(X;18) translocation: a case report

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Abstract

Synovial sarcoma (SS) is an uncommon soft tissue tumor occurring mainly in the periarticular region of the extremities of young adults. In this report, we describe a very rare occurrence of primary SS of the esophagus in a 72-year-old woman. Histologically, the tumor demonstrated biphasic morphologic findings associated with poorly differentiated areas. Tumor cells expressed vimentin, epithelial (EMA, CK7, AE1/3), bcl-2 and neuroectodermal (CD56, CD57, CD99) antigens. Differential diagnose included esophageal sarcomatoid carcinoma. Cytogenetic analysis confirmed the diagnosis of SS by identifying t(X;18) translocation. The literature of this very uncommon entity of the esophagus is reviewed.

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Acknowledgements

We are grateful to Elodie Basc and Mireille Mari for skilful technical assistance. This work was supported by the Programme Hospitalier de Recherche Clinique National 2003 du CHU de Nice, The Ligue Nationale Contre le Cancer, Comité des Alpes-Maritime and the Cancéropôle Provence Alpes-Côte d’Azur.

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Authors and Affiliations

  1. Laboratory of Clinical and Experimental Pathology and Human Tissue Biobank Unit, 30 Avenue de la Voie Romaine, Louis Pasteur Hospital, 06002, Nice, France

    Catherine Butori, Véronique Hofman & Paul Hofman

  2. Laboratory of Solid Tumors Genetics, Centre Hospitalier Universitaire de Nice and CNRS UMR 6543, Faculté de Medecine, Nice, France

    Rita Attias & Florence Pedeutour

  3. Department of Thoracic Surgery, 30 Avenue de la Voie Romaine, Louis Pasteur Hospital, 06002, Nice, France

    Jerôme Mouroux

Authors
  1. Catherine Butori
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  2. Véronique Hofman
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  3. Rita Attias
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  4. Jerôme Mouroux
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  5. Florence Pedeutour
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  6. Paul Hofman
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Corresponding author

Correspondence to Paul Hofman.

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Butori, C., Hofman, V., Attias, R. et al. Diagnosis of primary esophageal synovial sarcoma by demonstration of t(X;18) translocation: a case report. Virchows Arch 449, 262–267 (2006). https://doi.org/10.1007/s00428-006-0234-1

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  • DOI: https://doi.org/10.1007/s00428-006-0234-1

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