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Adenoma with gastric differentiation (so-called pyloric gland adenoma) in a heterotopic gastric corpus mucosa in the rectum

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Abstract

In a 46-year-old man, a pedunculated rectal polyp measuring 3.0×3.0×2.0 cm was diagnosed histologically as a pyloric gland-type adenoma arising in heterotopic gastric corpus mucosa. The luminal site was covered by glands of the gastric foveolar type, displaying focal marked proliferation interpreted as low-grade intraepithelial neoplasia. A bidirectional gastric differentiation was found: most lower glandular structures showed positivity for the deep gastric mucin core protein Muc 6 and superficial positivity for gastric foveolar epithelium mucin core protein Muc 5AC. Pyloric gland adenoma has so far been described in one larger series only and a few case reports of the stomach, gallbladder, pancreatic duct and within heterotopic gastric corpus mucosa of the duodenal bulb. The present case report is the first case of a pyloric gland-type adenoma within a gastric corpus heterotopia of the rectal mucosa.

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Acknowledgement

MV is supported by a grant of the Japanese Society of Pathology at Shiga University of Medical Science.

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Authors and Affiliations

  1. Institute of Pathology, Klinikum Bayreuth, Preuschwitzer Straße 101, 95445, Bayreuth, Germany

    M. Vieth, F. Oellig & M. Stolte

  2. Department of Clinical Science and Laboratory Medicine, Division of Diagnostic Pathology, Shiga University of Medical Science, Ohtsu, Shiga, 520-2192, Japan

    R. Kushima

  3. Institute of Pathology, Nordhorn, Hagenstraße 14, 48529, Nordhorn, Germany

    J. P. A. de Jonge

  4. Institute of Pathology, Klinikum Aschaffenburg, 63703, Aschaffenburg, Germany

    F. Borchard

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  1. M. Vieth
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  2. R. Kushima
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  3. J. P. A. de Jonge
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  4. F. Borchard
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  5. F. Oellig
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  6. M. Stolte
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Correspondence to M. Vieth.

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Vieth, M., Kushima, R., de Jonge, J.P.A. et al. Adenoma with gastric differentiation (so-called pyloric gland adenoma) in a heterotopic gastric corpus mucosa in the rectum. Virchows Arch 446, 542–545 (2005). https://doi.org/10.1007/s00428-005-1242-2

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  • DOI: https://doi.org/10.1007/s00428-005-1242-2

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