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Granular cell tumor of the neurohypophysis: report of a case with unusual age presentation

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Abstract

Granular cell tumor (GCT) usually occurs as a solitary, small, nodular tumor and rarely grows to a sufficient size to present symptoms. The tumor is more prevalent in female adults. The authors report a case of an 8-year-old boy with GCT of the neurohypophysis presenting with central precocious puberty. Few cases of symptomatic GCT have been reported in the literature, none of them in a patient in the first decade of life. Clinical picture, histopathological features, and histogenesis of GCT of neurohypophysis are discussed.

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References

  1. Asa LS (1998) Tumors of the pituitary gland. In: Atlas of tumor pathology, fasc 22, 3rd edn. Armed Forces Institute of Pathology, Washington, D.C., pp 159–160

    Google Scholar 

  2. Barrande G, Kujas M, Gancel A, Turpin G, Bruckert E, Kuhn JM, Luton JP (1995) Granular cell tumors. Rare tumors of the neurohypophysis. Presse Med 24(30):1376–1380

    PubMed  Google Scholar 

  3. Becker DH, Wilson CB (1981) Symptomatic parasellar granular cell tumors. Neurosurgery 8:173–180

    PubMed  Google Scholar 

  4. Buley ID, Gatter KC, Kelly PMA (1988) Granular cell tumors revisited. An immunohistological and ultrastructural study. Histopathology 12:263–274

    PubMed  Google Scholar 

  5. Chermaitilly W, Trivin C, Adan L, Gail V, Sainte-Rose C, Brauner R (2001) Central precocious puberty: clinical and laboratory features. Clin Endocrin (Oxf) 54:289–294

    Article  Google Scholar 

  6. Cusick JF, Ho K, Hagern TC, Kun L (1982) Granular cell pituicytoma associated with multiple endocrine neoplasia type 2. J Neurosurg 56:594–596

    PubMed  Google Scholar 

  7. Kasashima S, Oda Y, Nozaki J, Shirasaki M, Nakanishi I (2000) A case of atypical granular cell tumor of the neurohypophysis. Pathol Int 50:568–573

    Article  PubMed  Google Scholar 

  8. Lafitte C, Aesch B, Henry-Lebras F, Fetissof F, Jan M (1994) Granular cell tumor of the pituitary stalk. J Neurosurg 80:1103–1107

    PubMed  Google Scholar 

  9. Liwnicz BH, Liwnicz RG, Huff JS, McBride BH, Tew JM (1984) Giant granular cell tumor of the suprasellar area: immunocytochemical and electron microscopy studies. Neurosurgery 15:246–251

    PubMed  Google Scholar 

  10. Losa M, Saeger W, Mortini P, Pandolfi C, Terreni MR, Taccagni G, Giovanelli M (2000) Acromegaly associated with a granular cell tumor of the neurohypophysis: a clinical and histological study. J Neurosurg 93:121–126

    PubMed  Google Scholar 

  11. Lüthy F, Klinger J (1951) Der Tumoretten-Tumor des Hypophysenhinterlappens. Schweiz Z Allg Pathol Bakteriol 14:721–729

    Google Scholar 

  12. Markesberry WR, Duffy PE, Cowen D (1973) Granular cell tumors of the central nervous system. J Neuropathol Exp Neurol 32:92–109

    Google Scholar 

  13. Massie AP (1979) A granular cell pituicytoma of the neurohypophysis. J Pathol 129:53–56

    Article  PubMed  Google Scholar 

  14. Miettinen M, Lehtonen E, Lehtola H, Ekblorm P, Lehto VP, Virtanen I (1984) Histogenesis of granular cell tumor—an immunohistochemical and ultrastructural study. J Pathol 142:221–229

    Article  PubMed  Google Scholar 

  15. Nathrath WBJ, Remberger K (1986) Immunohistochemical study of the granular cell tumors. Virchows Arch B 53:52–57

    Google Scholar 

  16. Nishio S, Takeshita I, Yoshimoto K, Yamaguchi T (1998) Granular cell tumor of the pituitary stalk. Clin Neurol Neurosurg 100:144–147

    Article  PubMed  Google Scholar 

  17. Nishioka H, Kunio L, Llena JF, Hirano A (1991) Immunohistochemical study of granular cell tumors of the neurohypophysis. Virchows Arch B 60:413–417

    PubMed  Google Scholar 

  18. Rhee JS, Wackym PA, Hague K, King WA, Wolfe D (2002) Granular cell tumor of the pituitary fossa. Ann Otol Rhinol Laryngol 111:754–758

    PubMed  Google Scholar 

  19. Sarah A, Kernohan JW (1955) Granular cell tumors of the stalk and posterior lobe of the pituitary gland. Cancer 8(3):616–622

    PubMed  Google Scholar 

  20. Satyamurti S, Huntington HW (1972) Granular cell myoblastoma of the pituitary. J Neurosurg 37:483–486

    PubMed  Google Scholar 

  21. Schaller B, Kirsch E, Tolnay M, Mindermann T (1998) Symptomatic granular cell tumor of the pituitary gland: case report and review of the literature. Neurosurgery 42:166–171

    Article  PubMed  Google Scholar 

  22. Symon L, Ganz JC, Burston J (1971) Granular cell myoblastoma of the neurohypophysis. J Neurosurg 35:82–89

    PubMed  Google Scholar 

  23. Stanhope R (2001) Central precocious puberty and occult intracranial tumors. Clin Endocrin (Oxf) 54:287–288

    Article  Google Scholar 

  24. Sterberg C (1921) Ein Choristoma der Neruohypophyse bei ausgebreiteten Oedemen. Zentralbl Pathol Anat 31:585–591

    Google Scholar 

  25. Tomita T, Gates E (1999) Pituitary adenomas and granular cell tumors. Incidence, cell type, and location of tumors in 100 pituitary glands at autopsy. Am J Clin Pathol 111:817–825

    PubMed  Google Scholar 

  26. Ulrich J, Heitz PU, Fischer T, Obrist E, Gullotta F (1987) Granular cell tumors—evidence for heterogeneous tumor cell differentiation. An immunohistochemical study. Virchows Arch B 53:52–57

    PubMed  Google Scholar 

  27. Vogelgesang S, Junge MH, Pahnke J, Gaab MR, Warzok W (2002) August 2001: Sellar/Suparasellar mass in a 59 year-old woman. Brain Pathol 12(1):135–136, 139

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Hospital de Clinicas, Universidade Federal do Paraná (UFPR), Rua General Carneiro 181, 80060-900, Curitiba, Paraná, Brazil

    Paulo R. Benites Filho, Daniele Sakamoto, Tiago Noguchi Machuca, Maria José Serapião & Luiz F. Bleggi Torres

  2. Department of Neurosurgery, Hospital de Clinicas, UFPR, Curitiba, Brazil

    Leo Ditzel

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  1. Paulo R. Benites Filho
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  2. Daniele Sakamoto
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  3. Tiago Noguchi Machuca
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  4. Maria José Serapião
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  5. Leo Ditzel
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  6. Luiz F. Bleggi Torres
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Corresponding author

Correspondence to Luiz F. Bleggi Torres.

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Benites Filho, P.R., Sakamoto, D., Machuca, T.N. et al. Granular cell tumor of the neurohypophysis: report of a case with unusual age presentation. Virchows Arch 447, 649–652 (2005). https://doi.org/10.1007/s00428-005-1229-z

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  • DOI: https://doi.org/10.1007/s00428-005-1229-z

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