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Intravascular large T-cell lymphoma: a case report of CD30-positive and ALK-negative anaplastic type with cytotoxic molecule expression

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Abstract

We reported a case of intravascular T-cell lymphoma (T-IVL) with anaplastic large cell morphology, the hemophagocytic syndrome, and an aggressive clinical course. Phenotypic analysis of the tumor cells revealed CD2+, CD3−, CD4+, CD5−, CD8−, CD30+, CD56−, T-cell receptor alpha/beta−, ALK−, TIA1+, granzyme B+, and perforin+. No association with Epstein–Barr virus was found by in situ hybridization. A review revealed that 25 cases of T-IVL have been reported in the available literature, only two of which were of CD30+ anaplastic large cell or cytotoxic T-cell type. The findings in the present case may highlight the unique clinicopathologic aspects of a subset of CD30-positive T-IVLs with an ALK-negative cytotoxic phenotype.

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Authors and Affiliations

  1. Department of Pathology, Aichi Cancer Center, 1-1 Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan

    Emiko Takahashi

  2. Department of Pathology, Hyogo Medical Center for Adults, Akashi, Japan

    Kazuyoshi Kajimoto

  3. Clinical Laboratories, Nagoya Ekisaikai Hospital, Nagoya, Japan

    Toshiaki Fukatsu

  4. Department of Pathology, Nagoya City University School of Medicine, Nagoya, Japan

    Megumi Yoshida & Tadaaki Eimoto

  5. Department of Pathology and Clinical Laboratories, Nagoya University Hospital, Nagoya, Japan

    Shigeo Nakamura

Authors
  1. Emiko Takahashi
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  2. Kazuyoshi Kajimoto
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  3. Toshiaki Fukatsu
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  4. Megumi Yoshida
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  5. Tadaaki Eimoto
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  6. Shigeo Nakamura
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Correspondence to Emiko Takahashi.

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Takahashi, E., Kajimoto, K., Fukatsu, T. et al. Intravascular large T-cell lymphoma: a case report of CD30-positive and ALK-negative anaplastic type with cytotoxic molecule expression. Virchows Arch 447, 1000–1006 (2005). https://doi.org/10.1007/s00428-005-0080-6

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  • DOI: https://doi.org/10.1007/s00428-005-0080-6

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