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Simultaneous tumour-like, atypical basal cell hyperplasia and acinar adenocarcinoma of the prostate: a comparative morphological and genetic approach

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Abstract

Basal cell tumours of the prostatic gland are rare, and the classification is difficult. In the present case report, a large, tumour-like proliferation of atypical basaloid cells was found incidentally in a prostatectomy specimen that otherwise contained a conventional acinar adenocarcinoma. The basaloid cells displayed a solid or adenoid-cystic growth pattern and strongly expressed high-molecular-weight cytokeratins and bcl-2. A high Ki-67 index was recorded within the atypical basaloid cells, by far exceeding the one counted in the conventional adenocarcinoma. However, there were no definite criteria for a malignant behaviour of the basal cell tumour. Comparative genomic hybridisation from microdissected tumour cells yielded losses at the short arms of chromosomes 8 and 12 in the conventional adenocarcinoma and a normal karyotype in the basal cell tumour. The pathological findings favoured the diagnosis of an atypical basal cell hyperplasia.

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Authors and Affiliations

  1. Department of Urology, University of Hamburg, Germany

    A. M. Luebke & T. Schlomm

  2. Institute of Pathology, University of Göttingen, Germany

    B. Gunawan & L. Füzesi

  3. Institute of Pathology, Berlin, Germany

    H. Bonkhoff

  4. Institute of Pathology, University Hospital Hamburg-Eppendorf, Martinistrasse 52, 22081, Hamburg, Germany

    A. Erbersdobler

Authors
  1. A. M. Luebke
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  2. T. Schlomm
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  3. B. Gunawan
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  4. H. Bonkhoff
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  5. L. Füzesi
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  6. A. Erbersdobler
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Correspondence to A. Erbersdobler.

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Luebke, A.M., Schlomm, T., Gunawan, B. et al. Simultaneous tumour-like, atypical basal cell hyperplasia and acinar adenocarcinoma of the prostate: a comparative morphological and genetic approach. Virchows Arch 446, 338–341 (2005). https://doi.org/10.1007/s00428-004-1199-6

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  • DOI: https://doi.org/10.1007/s00428-004-1199-6

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