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Pyloric gland adenoma arising in Barrett’s esophagus with mucin immunohistochemical and molecular cytogenetic evaluation

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Abstract

Pyloric gland adenoma is a recently described and very rare entity. The occurrence of adenoma is very unusual in Barrett’s epithelium of the esophagus. We report a case of esophageal polyp showing the features of pyloric gland adenoma, which was surrounded by so-called specialized columnar epithelium. Immunohistochemically, most tumor glands were strongly positive for MUC6, except in the superficial layer. MUC5AC was positive in almost all tumor cells, but MUC2 and CD10 were negative in the tumor. MIB-1-positive proliferating cells were distributed throughout the tumor. Microdissection and comparative genomic hybridization analyses revealed losses on 2p24–25.2, 2q14.1-ter, 5q31.3–32, 6q23–24, 8q23–24.2, 11q22.3–24 and 18q21.1–22. This is the first case of pyloric gland adenoma found to arise in Barrett’s epithelium of the esophagus, showing its unstable and precancerous nature.

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Authors and Affiliations

  1. Division of Diagnostic Pathology, Shiga University of Medical Science, Seta, Otsu, 520-2192 , Shiga, Japan

    Ryoji Kushima, Rie Sakai & Hidetoshi Okabe

  2. Institute of Pathology, Klinikum Bayreuth, 95445 , Bayreuth, Germany

    Michael Vieth & Manfred Stolte

  3. Department of Pathology, Shiga University of Medical Science, Otsu, 520-2192 , Shiga, Japan

    Ken-ichi Mukaisho & Takanori Hattori

  4. Department of General Internal Medicine, Evangelisches Krankenhaus Düsseldorf, 40217 , Düsseldorf, Germany

    Horst Neuhaus

  5. Institute of Pathology, Klinikum Aschaffenburg, 63739 , Aschaffenburg, Germany

    Franz Borchard

Authors
  1. Ryoji Kushima
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  2. Michael Vieth
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  3. Ken-ichi Mukaisho
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  4. Rie Sakai
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  5. Hidetoshi Okabe
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  6. Takanori Hattori
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  7. Horst Neuhaus
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  8. Franz Borchard
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  9. Manfred Stolte
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Correspondence to Ryoji Kushima.

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Kushima, R., Vieth, M., Mukaisho, Ki. et al. Pyloric gland adenoma arising in Barrett’s esophagus with mucin immunohistochemical and molecular cytogenetic evaluation. Virchows Arch 446, 537–541 (2005). https://doi.org/10.1007/s00428-004-1185-z

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  • DOI: https://doi.org/10.1007/s00428-004-1185-z

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