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Mucoepidermoid carcinoma of the breast

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Abstract

Five cases of mucoepidermoid carcinoma (MEC) of the breast are reported. All patients were women ranging in age from 29 years to 80 years. As histological grading is one of the most important prognostic factors in breast invasive carcinomas, MEC was graded using the Auclair et al. [1] grading system specific for MEC of salivary glands and the Elston and Ellis [4] grading method, a widely employed grading system in breast cancer. It was found that the two different grading systems appear to be interchangeable in assessing the grade of MEC of the breast. Accordingly, three cases were regarded low grade (G. 1), one intermediate (G. 2) and one high grade (G. 3). The cases were studied with immunohistochemistry and were found to have the same keratin pattern shown by their salivary gland counterpart. It was found that there are more similarities than differences between MEC of the breast and of salivary glands.

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References

  1. Auclair PL, Goode RK, Ellis GL (1992) Mucoepidermoid carcinoma of intraoral salivary glands. Cancer 69:2021–2030

    CAS  PubMed  Google Scholar 

  2. Berry MG, Caldwell C, Carpenter R (1998) Mucoepidermoid carcinoma of the breast: a case report and review of the literature. Eur J Surg Oncol 24:78–80

    CAS  PubMed  Google Scholar 

  3. Di Tommaso L, Scarpellini F, Salvi F, Ragazzini T, Foschini MP (2000) Progesterone receptor expression in orbital cavernous hemangiomas. Virchows Arch 436:284–288

    PubMed  Google Scholar 

  4. Elston CW, Ellis IO (1991) Pathological prognostic factors in breast cancer. 1. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 19:403–410

    CAS  PubMed  Google Scholar 

  5. Fisher ER, Gregorio RM, Palekar AS, Paulson JD (1983) Mucoepidermoid and squamous cell carcinomas of breast with reference to squamous metaplasia and giant cell tumors. Am J Surg Pathol 7:15–27

    CAS  PubMed  Google Scholar 

  6. Foote FW, Becker WF, Stewart FW (1945) Muco-epidermoid tumors of salivary glands. Ann Surg 122:820–844

    Google Scholar 

  7. Foschini MP, Marucci G, Eusebi V (2002) Low-grade mucoepidermoid carcinoma of salivary glands: characteristic immunohistochemical profile and evidence of striated duct differentiation. Virchows Arch 440:536–542

    CAS  PubMed  Google Scholar 

  8. Foschini MP, Reis-Filho JS, Eusebi V, Lakhani SR (2003) Salivary gland-like tumours of the breast: surgical and molecular pathology. J Clin Pathol 56:497–506

    Article  PubMed  Google Scholar 

  9. Hanna W, Kahn HJ (1985) Ultrastructural and immunohistochemical characteristics of mucoepidermoid carcinoma of the breast. Hum Pathol 16:941–946

    CAS  PubMed  Google Scholar 

  10. Hastrup N, Sehested M (1985) High-grade mucoepidermoid carcinoma of the breast. Histopathology 9:887–892

    CAS  PubMed  Google Scholar 

  11. Holland R, Peterse JL, Millis RR, et al (1994) Ductal carcinoma in situ: a proposal for a new classification. Semin Diagn Pathol 11:167–180

    CAS  Google Scholar 

  12. Kovi J, Duong HD, Leffall LD (1981) High grade mucoepidermoid carcinoma of the breast. Arch Pathol Lab Med 105:612–614

    CAS  PubMed  Google Scholar 

  13. Leong AS-Y, Williams JAR (1985) Mucoepidermoid carcinoma of the breast: high grade variant. Pathology 17:516–521

    CAS  PubMed  Google Scholar 

  14. Luchtrath H, Moll R (1989) Mucoepidermoid mammary carcinoma. Immunohistochemical and biochemical analyses of intermediate filaments. Virchows Arch 416:105–113

    CAS  Google Scholar 

  15. Markopoulos C, Gogas H, Livaditou A, Floros D (1998) Mucoepidermoid carcinoma of the breast. J Gynecol Oncol 291–293

  16. Patchefsky AS, Frauenhoffer CM, Krall RA, Cooper HS (1979) Low grade mucoepidermoid carcinoma of the breast. Arch Pathol Lab Med 103:196–198

    CAS  PubMed  Google Scholar 

  17. Pettinato G, Insabato L, De Chiara A, Manco A, Petrella G (1989) High-grade mucoepidermoid carcinoma of the breast. Fine needle aspiration cytology and clinicopathologic study of a case. Acta Cytologica 33:195–200

    CAS  PubMed  Google Scholar 

  18. Tavassoli FA (1999) Pathology of the breast. Appleton-Lange, Stamford

  19. Tjalma WAA, Verslegers IOJ, De Loecker PAJ, Van Mark EAE (2002) Low and high grade mucoepidermoid carcinomas of the breast. Eur J Gynecol Oncol 23:423–425

    CAS  Google Scholar 

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Acknowledgements

Drs. S. Fiaccavento, P. Fontana, S. Rahimi, S. Sulfaro and S. Cerasoli must be thanked for having permitted the enclosure of cases 2, 3, 4, and 5. The work was granted by the University of Bologna (60%) and by the “Programma ricerca scientifica di rilevante interesse nazionale 2002” (40%).

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Authors and Affiliations

  1. Dipartimento di Scienze Oncologiche, Sezione di Anatomia Patologica, Università di Bologna, Ospedale Bellaria, Via Altura 3, 40139 , Bologna, Italy

    Luca Di Tommaso, Maria P. Foschini, Teresa Ragazzini, Elisabetta Magrini & Vincenzo Eusebi

  2. Anatomic Pathology, Ospedale Maggiore, Bologna, Italy

    Adele Fornelli

  3. Department of Histopathology, City Hospital NHS Trust, Nottingham, United Kingdom

    Ian O. Ellis

Authors
  1. Luca Di Tommaso
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  2. Maria P. Foschini
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  3. Teresa Ragazzini
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  4. Elisabetta Magrini
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  5. Adele Fornelli
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  6. Ian O. Ellis
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  7. Vincenzo Eusebi
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Corresponding author

Correspondence to Vincenzo Eusebi.

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Di Tommaso, L., Foschini, M.P., Ragazzini, T. et al. Mucoepidermoid carcinoma of the breast. Virchows Arch 444, 13–19 (2004). https://doi.org/10.1007/s00428-003-0923-y

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  • DOI: https://doi.org/10.1007/s00428-003-0923-y

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