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Ciprofloxacin-induced acute liver injury: case report and review of literature

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Abstract

Ciprofloxacin is a fluorinated quinolone antibiotic with relatively low occurrence of adverse side effects. However, increasing evidence suggests that ciprofloxacin may cause severe liver damage. Until now, 14 cases of ciprofloxacin-associated liver injuries have been reported. We describe a case of a 22-year-old male who developed hepatic failure after intake of ciprofloxacin. The patient had been treated with 2×250 mg ciprofloxacin per day. He presented with symptoms of acute liver failure 14 days later. Liver biopsy revealed extensive hepatocellular necrosis involving zones 3 and 2 of hepatic acini and a mixed inflammatory infiltration containing abundant eosinophils. Symptoms resolved after corticoidsteroid therapy. In the present paper, we report the clinico-pathological characteristics of a case of ciprofloxacin-associated acute hepatic failure and discuss the current literature.

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Authors and Affiliations

  1. Institute of Pathology, University of Basel, Schoenbeinstrasse 40, 4003 , Basel, Switzerland

    Annette Zimpfer & Luigi Terracciano

  2. Department of Gastroenterology and Hepatology, University Hospital Innsbruck, Anichstrasse 35, 6020 , Innsbruck, Austria

    Albert Propst & Wolfgang Vogel

  3. Institute of Pathology, University of Innsbruck, Muellerstrasse 44, 6020 , Innsbruck, Austria

    Gregor Mikuz & Sylvia Stadlmann

Authors
  1. Annette Zimpfer
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  2. Albert Propst
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  3. Gregor Mikuz
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  4. Wolfgang Vogel
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  5. Luigi Terracciano
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  6. Sylvia Stadlmann
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Corresponding author

Correspondence to Sylvia Stadlmann.

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Zimpfer, A., Propst, A., Mikuz, G. et al. Ciprofloxacin-induced acute liver injury: case report and review of literature. Virchows Arch 444, 87–89 (2004). https://doi.org/10.1007/s00428-003-0917-9

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  • DOI: https://doi.org/10.1007/s00428-003-0917-9

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