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Sarcomatoid salivary duct carcinoma of the oral cavity

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Abstract

This report recounts a new case of sarcomatoid variant of salivary duct carcinoma in a 45-year-old woman. The 1.5-cm polypoid mass protruded from the retromolar area and focally extended into the pharyngeal wall. The patient was free of disease for 11 years. The tumor showed a biphasic malignancy; nondescript sarcomatous proliferation predominated over ductal carcinoma population, with perceptible blending of the two components. The sarcomatoid areas had no heterologous properties. Discohesive pleomorphic cells were immunopositive for vimentin, epithelial membrane antigen and AE1/AE3 at a significant rate. A dual expression of AE1/AE3 and vimentin was also evident in enmeshed foci of conventional cribriform adenocarcinoma. Thus, the sarcomatoid histology represents a dedifferentiated phenotype of salivary duct carcinoma.

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References

  1. Batsakis JG, Suarez P (2000) Sarcomatoid carcinomas of the upper aerodigestive tracts. Adv Anat Pathol 7:282–293

    CAS  PubMed  Google Scholar 

  2. Bocklage T, Feddersen R (1995) Unusual mesenchymal and mixed tumors of the salivary gland. An immunohistochemical and flow cytometric analysis of three cases. Arch Pathol Lab Med 119:69–74

    CAS  PubMed  Google Scholar 

  3. Cheuk W, Chan JKC, Ngan RKC (1999) Dedifferentiation in adenoid cystic carcinoma of the salivary gland. An uncommon complication associated with an accelerated clinical course. Am J Surg Pathol 23:465–472

    Article  CAS  PubMed  Google Scholar 

  4. Ferreiro JA, Kochar AS (1994) Parotid acinic cell carcinoma with undifferentiated spindle cell transformation. J Laryngol Otol 108:902–904

    CAS  PubMed  Google Scholar 

  5. Guarino M, Micheli P, Pallotti F, Giordano F (1999) Pathological relevance of epithelial and mesenchymal phenotype plasticity. Pathol Res Pract 195:379–389

    CAS  PubMed  Google Scholar 

  6. Hansen LT, Kristensen S, Moesner J (1995) Polypoidal carcinosarcoma of the oropharynx: a clinicopathological and immunohistochemical study. J Laryngol Otol 109:459–465

    CAS  PubMed  Google Scholar 

  7. Harada H (2000) Histomorphological investigation regarding to malignant transformation of pleomorphic adenoma (so-called malignant mixed tumor) of the salivary gland origin: special reference to carcinosarcoma. Kurume Med J 47:307–323

    CAS  PubMed  Google Scholar 

  8. Henley JD, Seo IS, Dayan D, Gnepp DR (2000) Sarcomatoid salivary duct carcinoma of the parotid gland. Hum Pathol 31:208–213

    CAS  PubMed  Google Scholar 

  9. Ishibashi T, Hojo H (1995) Spindle cell carcinoma of the parotid gland. J Laryngol Otol 109:683–686

    CAS  PubMed  Google Scholar 

  10. Kamishima T, Fukuda T, Usuda H, Takato H, Iwamoto H, Kaneko H (1997) Carcinosarcoma of the urinary bladder: expression of epithelial markers and different expression of heat shock proteins between epithelial and sarcomatous elements. Pathol Int 47: 166–173

    CAS  PubMed  Google Scholar 

  11. Koss MN, Hochholzer L, Frommelt RA (1999) Carcinosarcomas of the lung. A clinicopathologic study of 66 patients. Am J Surg Pathol 23:1514–1526

    Article  CAS  PubMed  Google Scholar 

  12. Kwon MY, Gu M (2001) True malignant mixed tumor (carcinosarcoma) of parotid gland with unusual mesenchymal component. A case report and review of the literature. Arch Pathol Lab Med 125:812–815

    CAS  PubMed  Google Scholar 

  13. Latkovich P, Johnson RL (1998) Carcinosarcoma of the parotid gland. Report of a case with cytohistologic and immunohistochemical findings. Arch Pathol Lab Med 122:743–746

    CAS  PubMed  Google Scholar 

  14. Love GL, Sarma DP (1986) Spindle cell mucoepidermoid carcinoma of submandibular gland. J Surg Oncol 31:66–68

    CAS  PubMed  Google Scholar 

  15. Manuel S, Mathews A, Chandramohan K, Pandey M (2002) Carcinosarcoma of the parotid gland with epithelial-myoepithelial carcinoma and pleomorphic sarcoma components. Br J Oral Maxillofac Surg 40:480–483

    Article  CAS  PubMed  Google Scholar 

  16. Miyagi J, Tsuhako K, Kinjo T, Iwamasa T, Hashimoto H, Ishikawa S (2000) Rhabdoid tumour of the lung is a dedifferentiated phenotype of pulmonary adenocarcinoma. Histopathology 37:37–44

    Article  CAS  PubMed  Google Scholar 

  17. Nakayama Y, Murayama H, Iwasaki H, Iwanaga S, Kikuchi M, Ikeda S, Okada M, Iizuka Y, Iwashita A (1997) Gastric carcinosarcoma (sarcomatoid carcinoma) with rhabdomyoblastic and osteoblastic differentiation. Pathol Int 47:557–563

    CAS  PubMed  Google Scholar 

  18. Sreenan JJ, Hart WR (1995) Carcinosarcomas of the female genital tract. A pathologic study of 29 metastatic tumors: further evidence for the dominant role of the epithelial component and the conversion theory of histogenesis. Am J Surg Pathol 19:666–674

    CAS  PubMed  Google Scholar 

  19. Talmi YP, Halpern M, Finkelstein Y, Gal R, Zohar Y (1990) True malignant mixed tumour of the parotid gland. J Laryngol Otol 104:360–361

    CAS  PubMed  Google Scholar 

  20. Thompson LDR, Wieneke JA, Miettinen M, Heffner DK (2002) Spindle cell (sarcomatoid) carcinomas of the larynx. A clinicopathologic study of 187 cases. Am J Surg Pathol 26:153–170

    Article  PubMed  Google Scholar 

  21. Utsunomiya T, Yao T, Tamiya S, Tsuneyoshi M (2002) Intracellular distribution of intermediate filaments in vimentin-positive gastric carcinomas: confocal laser scanning microscopy using formalin-fixed paraffin-embedded specimens. Pathol Res Pract 198:69–76

    PubMed  Google Scholar 

  22. Weidner N (1987) Sarcomatoid carcinoma of the upper aerodigestive tract. Semin Diagn Pathol 4:157–168

    CAS  PubMed  Google Scholar 

  23. Wick MR, Ritter JH, Humphrey PA (1997) Sarcomatoid carcinomas of the lung. A clinicopathologic review. Am J Clin Pathol 108: 40–53

    CAS  PubMed  Google Scholar 

  24. Zarbo RJ (2002) Salivary gland neoplasia: a review for the practicing pathologist. Mod Pathol 15:298–323

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, 350-0283, Yokohama , Japan

    Fumio Ide, Kenji Mishima & Ichiro Saito

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  1. Fumio Ide
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  2. Kenji Mishima
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  3. Ichiro Saito
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Correspondence to Fumio Ide.

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Ide, F., Mishima, K. & Saito, I. Sarcomatoid salivary duct carcinoma of the oral cavity. Virchows Arch 443, 686–689 (2003). https://doi.org/10.1007/s00428-003-0876-1

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  • DOI: https://doi.org/10.1007/s00428-003-0876-1

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