Skip to main content

Advertisement

SpringerLink
Log in

CD31 staining in epithelioid sarcoma

  • Case Report
  • Published:
Virchows Archiv Aims and scope Submit manuscript

Abstract

We report an unusual case of epithelioid sarcoma. The tumour occurred in the finger of a 27-year-old female. The clinical history, histology and the electron microscopy of the lesion were typical for epithelioid sarcoma. However, immunohistochemical analysis showed strong membranous CD31 staining, a finding hitherto not described. All other robust vascular markers, including factor-VIII-related antigen (FVIIIrag) were negative. The findings were compared with the available literature data, leading us to conclude that there is insufficient evidence for endothelial derivation of epithelioid sarcoma, but in the differential diagnosis with vascular tumours CD31 may stain and to rule out angiosarcoma FVIIIrag is a useful antibody.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig 2.
Fig. 3.

Similar content being viewed by others

References

  1. Arber DA, Kandalaft PL, Mehta P, Battifora H (1993) Vimentin-negative epithelioid sarcoma. The value of an immunohistochemical panel that includes CD34. Am J Surg Pathol 17:302–307

    CAS  PubMed  Google Scholar 

  2. Billings SD, Folpe AL, Weiss SW (2003) Epithelioid sarcoma-like hemangioendothelioma. Am J Surg Pathol 27:48–57

    Article  PubMed  Google Scholar 

  3. Chase DR, Enzinger FM (1985) Epithelioid sarcoma. Diagnosis, prognostic indicators, and treatment. Am J Surg Pathol 9:241–263

    CAS  PubMed  Google Scholar 

  4. DeYoung BR, Swanson PE, Argenyi ZB, Ritter JH, Fitzgibbon JF, Stahl DJ, Hoover W, Wick MR (1995) CD31 immunoreactivity in mesenchymal neoplasms of the skin and subcutis: report of 145 cases and review of putative immunohistologic markers of endothelial differentiation. J Cutan Pathol 22:215–222

    CAS  PubMed  Google Scholar 

  5. Enzinger FM (1970) Epitheloid sarcoma. A sarcoma simulating a granuloma or a carcinoma. Cancer 26:1029–1041

    CAS  PubMed  Google Scholar 

  6. Fisher C (1988) Epithelioid sarcoma: the spectrum of ultrastructural differentiation in seven immunohistochemically defined cases. Hum Pathol 19:265–275

    CAS  PubMed  Google Scholar 

  7. Fletcher CD, Beham A, Bekir S, Clarke AM, Marley NJ (1991) Epithelioid angiosarcoma of deep soft tissue: a distinctive tumor readily mistaken for an epithelial neoplasm. Am J Surg Pathol 15:915–924

    CAS  PubMed  Google Scholar 

  8. Folpe AL, Chand EM, Goldblum JR, Weiss SW (2001) Expression of Fli-1, a nuclear transcription factor, distinguishes vascular neoplasms from potential mimics. Am J Surg Pathol 25:1061–1066

    Article  CAS  PubMed  Google Scholar 

  9. Guillou L, Wadden C, Coindre JM, Krausz T, Fletcher CD (1997) "Proximal-type" epithelioid sarcoma, a distinctive aggressive neoplasm showing rhabdoid features. Clinicopathologic, immunohistochemical, and ultrastructural study of a series. Am J Surg Pathol 21:130–146

    CAS  PubMed  Google Scholar 

  10. Hasegawa T, Matsuno Y, Shimoda T, Umeda T, Yokoyama R, Hirohashi S (2001) Proximal-type epithelioid sarcoma: a clinicopathologic study of 20 cases. Mod Pathol 14:655–663

    CAS  PubMed  Google Scholar 

  11. Manivel JC, Wick MR, Dehner LP, Sibley RK (1987) Epithelioid sarcoma. An immunohistochemical study. Am J Clin Pathol 87:319–326

    CAS  PubMed  Google Scholar 

  12. Miettinen M, Fetsch JF (2000) Distribution of keratins in normal endothelial cells and a spectrum of vascular tumors: implications in tumor diagnosis. Hum Pathol 31:1062–1067

    Article  CAS  PubMed  Google Scholar 

  13. Miettinen M, Lehto VP, Vartio T, Virtanen I (1982) Epithelioid sarcoma. Ultrastructural and immunohistologic features suggesting a synovial origin. Arch Pathol Lab Med 106:620–623

    CAS  PubMed  Google Scholar 

  14. Miettinen M, Lindenmayer AE, Chaubal A (1994) Endothelial cell markers CD31, CD34, and BNH9 antibody to H- and Y- antigens—evaluation of their specificity and sensitivity in the diagnosis of vascular tumors and comparison with von Willebrand factor. Mod Pathol 7:82–90

    CAS  PubMed  Google Scholar 

  15. Miettinen M, Fanburg-Smith JC, Virolainen M, Shmookler BM, Fetsch JF (1999) Epithelioid sarcoma: an immunohistochemical analysis of 112 classical and variant cases and a discussion of the differential diagnosis. Hum Pathol 30:934–942

    CAS  PubMed  Google Scholar 

  16. Mukai M, Torikata C, Iri H, Hanaoka H, Kawai T, Yakumaru K, Shimoda T, Mikata A, Kageyama K (1985) Cellular differentiation of epithelioid sarcoma. An electron- microscopic, enzyme-histochemical, and immunohistochemical study. Am J Pathol 119:44–56

    CAS  PubMed  Google Scholar 

  17. Quezado M (1996) Epithelioid sarcomas: prognostic factors and immunohistochemical profile (abstract). Mod Pathol 9:12

    Google Scholar 

  18. Smith ME, Brown JI, Fisher C (1998) Epithelioid sarcoma: presence of vascular-endothelial cadherin and lack of epithelial cadherin. Histopathology 33:425–431

    Article  CAS  PubMed  Google Scholar 

  19. von Hochstetter AR, Grant JW, Meyer VE, Honegger HP,Schreiber A (1990) Angiomatoid variant of epithelioid sarcoma. The value of immunohistochemistry in the differential diagnosis. Chir Organi Mov 75:158–162

    PubMed  Google Scholar 

  20. von Hochstetter AR, Meyer VE, Grant JW, Honegger HP,Schreiber A (1991) Epithelioid sarcoma mimicking angiosarcoma: the value of immunohistochemistry in the differential diagnosis. Virchows Arch 418:271–278

    Google Scholar 

  21. Wick MR, Manivel JC (1987) Epithelioid sarcoma and epithelioid hemangioendothelioma: an immunocytochemical and lectin-histochemical comparison. Virchows Arch 410:309–316

    CAS  Google Scholar 

Download references

Acknowledgements

The authors wish to thank Prof. C.D.M. Fletcher, Brigham and Women's Hospital, Boston USA for his expert opinion in this case.

Author information

Authors and Affiliations

  1. Department of Pathology, Erasmus Medical Center, PO Box 1738, 3000 DR, Rotterdam, Netherlands

    M. A. den Bakker & M. Kliffen

  2. Department of Plastic and Reconstructive Surgery, Erasmus MC, Rotterdam, Netherlands

    S. J. Flood

Authors
  1. M. A. den Bakker
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. J. Flood
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Kliffen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. A. den Bakker.

Rights and permissions

Reprints and permissions

About this article

Cite this article

den Bakker, M.A., Flood, S.J. & Kliffen, M. CD31 staining in epithelioid sarcoma. Virchows Arch 443, 93–97 (2003). https://doi.org/10.1007/s00428-003-0829-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00428-003-0829-8

Keywords

Search

Navigation