Abstract
The work presented in this study focuses on blastema formation in epimorphic regeneration. We describe the expression pattern of Sdf1a and Sdf1b (the chemokines stromal-cell-derived factor-1a and 1b) and their two receptors Cxcr4a and Cxcr4b during zebrafish fin regeneration. We demonstrate that Sdf1a/Cxcr4a plays a critical role in fin regeneration and more precisely in epidermal cell proliferation, an important process for blastema formation. In mammals, a single cxcr4 gene is involved both in chemotaxis and cell proliferation and survival; we discuss in this study a possible functional division of the two cxcr4 zebrafish genes.
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Acknowledgements
The authors would like to thank Frédéric Rosa at the Ecole Normale Superieure (Paris, France) and Patrick Blader (Centre de Biologie du Développement, Toulouse, France) in whose laboratories these experiments were initiated, and Holger Knaut for odysseus mutant. The authors are very grateful to Nadine Peyrièras and Oreste Acuto for their support, and to Fernando Roch, Keir Neuman, and anonymous reviewers for their comments.
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Communicated by M. Hammerschmidt
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Dufourcq, P., Vriz, S. The chemokine SDF-1 regulates blastema formation during zebrafish fin regeneration. Dev Genes Evol 216, 635–639 (2006). https://doi.org/10.1007/s00427-006-0066-7
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DOI: https://doi.org/10.1007/s00427-006-0066-7