References
Cannon SC (2010) Voltage-sensor mutations in channelopathies of skeletal muscle. J Physiol 588(Pt 11):1887–1895
Di Stefano G, Yuan JH, Cruccu G, Waxman SG, Dib-Hajj SD, Truini A (2020) Familial trigeminal neuralgia - a systematic clinical study with a genomic screen of the neuronal electrogenisome. Cephalalgia 40(8):767–777
Eide PK (2022) Familial occurrence of classical and idiopathic trigeminal neuralgia. J Neurol Sci 434:120101
Gambeta E, Chichorro JG, Zamponi GW (2020) Trigeminal neuralgia: an overview from pathophysiology to pharmacological treatments. Mol Pain 16:1744806920901890
Gambeta E, Gandini MA, Souza IA, Zamponi GW (2022) Cav3.2 calcium channels contribute to trigeminal neuralgia. Pain. https://doi.org/10.1097/j.pain.0000000000002651
Gualdani R, Yuan JH, Effraim PR, Di Stefano G, Truini A, Cruccu G, Dib-Hajj SD, Gailly P, Waxman SG (2021) Trigeminal neuralgia trpm8 mutation: enhanced activation, basal [ca2+]I and menthol response. Neurol Genet 7(1):e550
Jani RH, Hughes MA, Gold MS, Branstetter BF, Ligus ZE, Sekula RF (2019) Trigeminal nerve compression without trigeminal neuralgia: intraoperative vs imaging evidence. Neurosurgery 84(1):60–65
Magown P, Ko AL, Burchiel KJ (2019) The spectrum of trigeminal neuralgia without neurovascular compression. Neurosurgery 85(3):E553–E559
Mannerak MA, Lashkarivand A, Eide PK (2021) Trigeminal neuralgia and genetics: a systematic review. Mol Pain 17:17448069211016140
Tanaka BS, Zhao P, Dib-Hajj FB, Morisset V, Tate S, Waxman SG, Dib-Hajj SD (2016) A gain-of-function mutation in nav1.6 in a case of trigeminal neuralgia. Mol Med 22:338–348
Zou ZG, Rios FJ, Montezano AC, Touyz RM (2019) Trpm7, magnesium, and signaling. Int J Mol Sci 20(8):E1877
Funding
N.W. is supported by a grant from the Czech Science Foundation (GACR #22-23242S) and the National Institute for Research of Metabolic and Cardiovascular Diseases (Programme EXCELES # LX22NPO5104), funded by the European Union – Next Generation EU.
Author information
Authors and Affiliations
Contributions
N.W. and G.W.Z. planned and wrote the whole Commentary.
Corresponding author
Ethics declarations
Competing interests
G.W.Z. is Chief Scientific Officer of Zymedine Therapeutics.
Conflict of interests
N.W. has no competing interests to declare. G.W.Z. is Chief Scientific Officer of Zymedine Therapeutics.
Additional information
Publisher's note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Commentary to the article: A TRPM7 mutation linked to familial trigeminal neuralgia: omega current and hyperexcitability of trigeminal ganglion neurons (Gualdani et al., Proc. Natl. Acad. Sci. USA. 119(38):e2119630119, 2022).
Rights and permissions
About this article
Cite this article
Weiss, N., Zamponi, G.W. The omega of TRPM7 channels in trigeminal neuralgia. Pflugers Arch - Eur J Physiol 474, 1213–1215 (2022). https://doi.org/10.1007/s00424-022-02757-w
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00424-022-02757-w