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Channelopathies of voltage-gated L-type Cav1.3/α1D and T-type Cav3.1/α1G Ca2+ channels in dysfunction of heart automaticity

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A Correction to this article was published on 09 July 2020

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Abstract

The heart automaticity is a fundamental physiological function in vertebrates. The cardiac impulse is generated in the sinus node by a specialized population of spontaneously active myocytes known as “pacemaker cells.” Failure in generating or conducting spontaneous activity induces dysfunction in cardiac automaticity. Several families of ion channels are involved in the generation and regulation of the heart automaticity. Among those, voltage-gated L-type Cav1.3 (α1D) and T-type Cav3.1 (α1G) Ca2+ channels play important roles in the spontaneous activity of pacemaker cells. Ca2+ channel channelopathies specifically affecting cardiac automaticity are considered rare. Recent research on familial disease has identified mutations in the Cav1.3-encoding CACNA1D gene that underlie congenital sinus node dysfunction and deafness (OMIM # 614896). In addition, both Cav1.3 and Cav3.1 channels have been identified as pathophysiological targets of sinus node dysfunction and heart block, caused by congenital autoimmune disease of the cardiac conduction system. The discovery of channelopathies linked to Cav1.3 and Cav3.1 channels underscores the importance of Ca2+ channels in the generation and regulation of heart’s automaticity.

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  • 09 July 2020

    The above article was published online with an error in Fig.��1b. There is a doubled action potential at the far right of the left panel of the figure.

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Funding

The group is a member of the Laboratory of Excellence “Ion Channel Science and Therapeutics” supported by a grant from ANR (ANR-11-LABX-0015). This research was supported by the Fondation pour la Recherche Medicale “Physiopathologie Cardiovasculaire” (DPC20171138970, M.E.M.) and by the Agence Nationale de la Recherche (ANR-15-CE14-0004-01, M.E.M.). We also thank the Fondation Leducq (TNE 19CVD03; to Matteo E. Mangoni and Peter J. Mohler) for supporting the “Fighting Against Sinus Node Dysfunction and Associated Arrhythmias” (FANTASY) network.

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  1. Angelo G. Torrente and Pietro Mesirca contributed equally to this work.

Authors and Affiliations

  1. Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, 141, rue de la cardonille, 34094, Montpellier, France

    Angelo G. Torrente, Pietro Mesirca, Isabelle Bidaud & Matteo E. Mangoni

  2. LabEx Ion Channels Science and Therapeutics (ICST), Montpellier, France

    Angelo G. Torrente, Pietro Mesirca, Isabelle Bidaud & Matteo E. Mangoni

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  1. Angelo G. Torrente
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  2. Pietro Mesirca
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  3. Isabelle Bidaud
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  4. Matteo E. Mangoni
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Correspondence to Matteo E. Mangoni.

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The original version of this article was revised: The above article was published online with an error in Figure 1b. There is a doubled action potential at the far right of the left panel of the figure.

This article is part of the special issue on Channelopathies: from mutation to diseases in Pflügers Archiv—European Journal of Physiology

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Torrente, A.G., Mesirca, P., Bidaud, I. et al. Channelopathies of voltage-gated L-type Cav1.3/α1D and T-type Cav3.1/α1G Ca2+ channels in dysfunction of heart automaticity. Pflugers Arch - Eur J Physiol 472, 817–830 (2020). https://doi.org/10.1007/s00424-020-02421-1

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