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Glucose transport in lymphocytes

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Abstract

Glucose uptake into lymphocytes is accomplished by non-concentrative glucose carriers of the GLUT family (GLUT1, GLUT3, GLUT4, GLUT6) and/or by the Na+-coupled glucose carrier SGLT1. The latter accumulates glucose against glucose gradients and is still effective at very low extracellular glucose concentrations. Signaling involved in SGLT1 expression and activity includes protein kinase A (PKA), protein kinase C (PKC), serum- and glucocorticoid-inducible kinase (SGK1), AMP-activated kinase (AMPK), and Janus kinases (JAK2 and JAK3). Glucose taken up is partially stored as glycogen. In hypoxic environments, such as in tumors as well as infected and inflamed tissues, lymphocytes depend on energy production from glycogen-dependent glycolysis. The lack of SGLT1 may compromise glycogen storage and thus lymphocyte survival and function in hypoxic tissues. Accordingly, in mice, genetic knockout of sglt1 compromised bacterial clearance following Listeria monocytogenes infection leading to an invariably lethal course of the disease. Whether the effect was due to the lack of sglt1 in lymphocytes or in other cell types still remains to be determined. Clearly, additional experimental effort is required to define the role of glucose transport by GLUTs and particularly by SGLT1 for lymphocyte survival and function, as well as orchestration of the host defense against tumors and bacterial infections.

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Acknowledgments

The authors acknowledge the meticulous preparation of the manuscript by Lejla Subasic.

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Authors and Affiliations

  1. Department of Physiology, Eberhard Karl University, Tubingen, Germany

    Florian Lang & Ke Ma

  2. Department of Physiology, University of Tübingen, Wilhelmstr. 56, 72076, Tubingen, Germany

    Florian Lang

  3. Institute of Medical Genetics and Applied Genomics, Eberhard Karl University, Tubingen, Germany

    Yogesh Singh

  4. Research Institute of Women’s Health, Eberhard Karl University, Tubingen, Germany

    Madhuri S. Salker

  5. Department of Molecular Medicine II, Heinrich Heine University Düsseldorf, Dusseldorf, Germany

    Aleksandra A. Pandyra & Philipp A. Lang

  6. Department of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Dusseldorf, Germany

    Aleksandra A. Pandyra

  7. Department of Immunology, University of Essen, Essen, Germany

    Karl S. Lang

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  1. Florian Lang
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  2. Yogesh Singh
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  3. Madhuri S. Salker
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  4. Ke Ma
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  5. Aleksandra A. Pandyra
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  6. Philipp A. Lang
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  7. Karl S. Lang
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Correspondence to Florian Lang.

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This article is part of the special issue on Glucose Transporters in Health and Disease in Pflügers Archiv—European Journal of Physiology

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Lang, F., Singh, Y., Salker, M.S. et al. Glucose transport in lymphocytes. Pflugers Arch - Eur J Physiol 472, 1401–1406 (2020). https://doi.org/10.1007/s00424-020-02416-y

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  • DOI: https://doi.org/10.1007/s00424-020-02416-y

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