Abstract
In cardiovascular diseases and during aging, endothelial dysfunction is due in part to the release of endothelium-derived contracting factors that counteract the vasodilator effect of the nitric oxide. Endothelium-dependent contractions involve the activation of endothelial cyclooxygenases and the release of various prostanoids, which activate thromboxane prostanoid (TP) receptors of the underlying vascular smooth muscle. The stimulation of TP receptors elicits not only the contraction and the proliferation of vascular smooth muscle cells but also diverse physiological/pathophysiological reactions, including platelet aggregation and activation of endothelial inflammatory responses. TP receptor antagonists curtail endothelial dysfunction in diseases such as hypertension and diabetes, are potent antithrombotic agents, and prevent vascular inflammation.
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Alvarez de Sotomayor M, Mingorance C, Andriantsitohaina R (2007) Fenofibrate improves age-related endothelial dysfunction in rat resistance arteries. Atherosclerosis 193:112–120
Alvarez Y, Briones AM, Balfagón G, Alonso MJ, Salaices M (2005) Hypertension increases the participation of vasoconstrictor prostanoids from cyclooxygenase-2 in phenylephrine responses. J Hypertens 23:767–777
Arikawa E, Cheung C, Sekirov I, Battell ML, Yuen VG, McNeill JH (2006) Effects of endothelin receptor blockade on hypervasoreactivity in streptozotocin-diabetic rats: vessel-specific involvement of thromboxane A2. Can J Physiol Pharmacol 84:823–833
Auch-Schwelk W, Katusic ZS, Vanhoutte PM (1989) Contractions to oxygen-derived free radicals are augmented in aorta of the spontaneously hypertensive rat. Hypertension 13:859–864
Auch-Schwelk W, Katusic ZS, Vanhoutte PM (1990) Thromboxane A2 receptor antagonists inhibit endothelium-dependent contractions. Hypertension 15:699–703
Belhassen L, Pelle G, Dubois-Rande J, Adnot S (2003) Improved endothelial function by the thromboxane a2 receptor antagonist s 18886 in patients with coronary artery disease treated with aspirin. J Am Coll Cardiol 41:1198–1204
Blanco-Rivero J, Cachofeiro V, Lahera V, Aras-Lopez R, Márquez-Rodas I, Salaices M, Xavier FE, Ferrer M, Balfagón G (2005) Participation of prostacyclin in endothelial dysfunction induced by aldosterone in normotensive and hypertensive rats. Hypertension 46:107–112
Camacho M, Lopez-Belmonte J, Vila L (1998) Rate of vasoconstrictor prostanoids released by endothelial cells depends on cyclooxygenase-2 expression and prostaglandin I synthase activity. Circ Res 83:353–365
Cayatte AJ, Du Y, Oliver-Krasinski J, Lavielle G, Verbeuren TJ, Cohen RA (2000) The thromboxane receptor antagonist S18886 but not aspirin inhibits atherogenesis in apo E-deficient mice: evidence that eicosanoids other than thromboxane contribute to atherosclerosis. Arterioscler Thromb Vasc Biol 20:1724–1728
Chenevard R, Hürlimann D, Béchir M, Enseleit F, Spieker L, Hermann M, Riesen W, Gay S, Gay RE, Neidhart M, Michel B, Lüscher TF, Noll G, Ruschitzka F (2003) Selective COX-2 inhibition improves endothelial function in coronary artery disease. Circulation 107:405–409
Cohen RA (2002) Does EDCF contribute to diabetic endothelial cell dysfunction? Dialog Cardiovasc Med 7:225–231
Davidge ST (2001) Prostaglandin H synthase and vascular function. Circ Res 89:650–660
De Mey JG, Vanhoutte PM (1982) Heterogeneous behavior of the canine arterial and venous wall. Importance of the endothelium. Circ Res 51:439–447
De Vriese AS, Verbeuren TJ, Van de Voorde J, Lameire NH, Vanhoutte PM (2000) Endothelial dysfunction in diabetes. Br J Pharmacol 130:963–974
De Witt DL, Day JS, Sonnenburg WK, Smith WL (1983) Concentrations of prostaglandin endoperoxide synthase and prostaglandin I2 synthase in the endothelium and smooth muscle of bovine aorta. J Clin Invest 72:1882–1888
De Witt DL, Smith WL (1988) Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence. Proc Natl Acad Sci U S A 85:1412–1416
Félétou M, Vanhoutte PM (2006) Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture). Am J Physiol Heart Circ Physiol 291:H985–H1002
Félétou M, Vanhoutte PM, Verbeuren TJ (2010) The TP-receptor: the common villain. J Cardiovasc Pharmacol (in press)
Flavahan NA (2007) Balancing prostanoid activity in the human vascular system. Trends Pharmacol Sci 28:106–110
Fonlupt P, Croset M, Lagarde M (1991) 12-HETE inhibits the binding of PGH2/TXA2 receptor ligands in human platelets. Thromb Res 63:239–248
Funk CD, FitzGerald GA (2007) COX-2 inhibitors and cardiovascular risk. J Cardiovasc Pharmacol 50:470–479
Garcia-Cohen EC, Marin J, Diez-Picazo LD, Baena AB, Salaices M, Rodriguez-Martinez MA (2000) Oxidative stress induced by tert-butyl hydroperoxide causes vasoconstriction in the aorta from hypertensive and aged rats: role of cyclooxygenase-2 isoform. J Pharmacol Exp Ther 293:75–81
Ge T, Hughes H, Junquero DC, Wu KK, Vanhoutte PM, Boulanger CM (1995) Endothelium dependent contractions are associated with both augmented expression of prostaglandin H synthase-1 and hypersensitivity to prostaglandin H2 in the SHR aorta. Circ Res 76:1003–1010
Gendron ME, Thorin E (2007) A change in the redox environment and thromboxane A2 production precede endothelial dysfunction in mice. Am J Physiol Heart Circ Physiol 293:H2508–H2515
Gluais P, Lonchampt M, Morrow JD, Vanhoutte PM, Félétou M (2005) Acetylcholine-induced endothelium-dependent contractions in the SHR aorta: the Janus face of prostacyclin. Br J Pharmacol 146:834–845
Gluais P, Paysant J, Badier-Commander C, Verbeuren T, Vanhoutte PM, Félétou M (2006) In SHR aorta, calcium ionophore A-23187 releases prostacyclin and thromboxane A2 as endothelium-derived contracting factors. Am J Physiol Heart Circ Physiol 291:H2255–H2564
Gluais P, Vanhoutte PM, Félétou M (2007) Mechanisms underlying ATP-induced endothelium-dependent contractions in the SHR aorta. Eur J Pharmacol 556:107–114
Gomez E, Schwendemann C, Roger S, Simonet S, Paysant J, Courchay C, Verbeuren TJ, Félétou M (2008) Aging and prostacyclin responses in aorta and platelets from WKY and SHR rats. Am J Physiol Heart Circ Physiol 295:H2198–H2211
Graham DA, Rush JW (2009) Cyclooxygenase and thromboxane/prostaglandin receptor contribute to aortic endothelium-dependent dysfunction in aging female spontaneously hypertensive rats. J Appl Physiol 107:1059–1067
Gryglewski RJ, Palmer RM, Moncada S (1986) Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature 320:454–456
Harlan JM, Callahan KS (1984) Role of hydrogen peroxide in the neutrophil-mediated release of prostacyclin from cultured endothelial cells. J Clin Invest 74:442–448
Heymes C, Habib A, Yang D, Mathieu E, Marotte F, Samuel JL, Boulanger CM (2000) Cyclo-oxygenase-1 and –2 contribution to endothelial dysfunction in ageing. Br J Pharmacol 131:804–810
Hla T, Neilson K (1992) Human cyclooxygenase-2 cDNA. Proc Natl Acad Sci U S A 89:7384–7388
Iwama Y, Kato T, Muramatsu M, Asano H, Shimizu K, Toki Y, Miyazaki Y, Okumura K, Hashimoto H, Ito T, Satake T (1992) Correlation with blood pressure of the acetylcholine-induced endothelium-derived contracting factor in the rat aorta. Hypertension 19:326–332
Kato T, Iwama Y, Okumura K, Hashimoto H, Ito T, Satake T (1990) Prostaglandin H2 may be the endothelium-derived contracting factor released by acetylcholine in the aorta of the rat. Hypertension 15:475–481
Katugampola SD, Davenport AP (2001) Thromboxane receptor density is increased in human cardiovascular disease with evidence for inhibition at therapeutic concentrations by the AT(1) receptor antagonist losartan. Br J Pharmacol 134:1385–1392
Katusic Z, Shepherd JT, Vanhoutte PM (1987) Endothelium-dependent contraction to stretch in canine basilar arteries. Am J Physiol 21:H671–H673
Katusic ZS, Shepherd JT, Vanhoutte PM (1988) Endothelium-dependent contractions to calcium ionophore A23187, arachidonic acid and acetylcholine in canine basilar arteries. Stroke 19:476–479
Katusic ZS, Vanhoutte PM (1989) Superoxide anion is an endothelium-derived contracting factor. Am J Physiol 257:H33–H37
Kauser K, Rubanyi GM (1995) Gender difference in endothelial dysfunction in the aorta of spontaneously hypertensive rats. Hypertension 25:517–523
Kawka DW, Ouellet M, Hétu PO, Singer II, Riendeau D (2007) Double-label expression studies of prostacyclin synthase, thromboxane synthase and COX isoforms in normal aortic endothelium. Biochim Biophys Acta 1771:45–54
Kiriyama M, Ushikubi F, Kobayashi T, Hirata M, Sugimoto Y, Narumiya S (1997) Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol 122:217–224
Koga T, Takata Y, Kobayashi K, Takeshita S, Yamashita Y, Fujishima M (1988) Ageing suppresses endothelium-dependent relaxation and generates contraction mediated by the muscarinic receptors in vascular smooth muscle of normotensive Wistar Kyoto and spontaneously hypertensive rats. J Hypertens 6:S243–S245
Koga T, Takata Y, Kobayashi K, Takishita S, Yamashita Y, Fujishima M (1989) Age and hypertension promote endothelium-dependent contractions to acetylcholine in the aorta of the rat. Hypertension 14:542–548
Liu CQ, Leung FP, Wong SL, Wong WT, Lau CW, Lu L, Yao X, Yao T, Huang Y (2009) Thromboxane prostanoid receptor activation impairs endothelial nitric oxide-dependent vasorelaxations: the role of Rho kinase. Biochem Pharmacol 78:374–381
Lüscher TF, Vanhoutte PM (1986) Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat. Hypertension 8:344–348
Lüscher TF, Cooke JP, Houston DS, Neves RJ, Vanhoutte PM (1987) Endothelium-dependent relaxations in human arteries. Mayo Clin Proc 62:601–606
Matsumoto T, Kakami M, Noguchi E, Kobayashi T, Kamata K (2007) Imbalance between endothelium-derived relaxing and contracting factors in mesenteric arteries from aged OLETF rats, a model of Type 2 diabetes. Am J Physiol Heart Circ Physiol 293:H1480–H1490
Matz RL, de Sotomayor MA, Schott C, Stoclet JC, Andriantsitohaina R (2000) Vascular bed heterogeneity in age-related endothelial dysfunction with respect to NO and eicosanoids. Br J Pharmacol 131:303–311
Mazzone T, Chait A, Plutzky J (2008) Cardiovascular disease risk in type 2 diabetes mellitus: insights from mechanistic studies. Lancet 371:1800–1809
McAdam BF, Catella-Lawson F, Mardini IA, Kapoor S, Lawson JA, FitzGerald GA (1999) Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2. Proc Natl Acad Sci U S A 96:272–277
Meeking D, Browne D, Allard S, Munday J, Chowienczyk P, Shaw KM, Cummings MH (2000) Effects of cyclo-oxygenase inhibition on vasodilatory response to acetylcholine in patients with type 1 diabetes and nondiabetic. Diabetes Care 23:1–4
Merlie JP, Fagan D, Mudd J, Needleman P (1988) Isolation and characterization of the complementary DNA for sheep seminal prostaglandins endoperoxide synthase (cyclooxygenase). J Biol Chem 263:3550–3553
Miller VM, Vanhoutte PM (1985) Endothelium-dependent contractions to arachidonic acid are mediated by products of cyclo-oxygenase in canine veins. Am J Physiol 248:H432–H437
Moncada S, Gryglewski RJ, Bunting S, Vane JR (1976) An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 263:663–665
Moncada S, Herman AG, Higgs EA, Vane JR (1977) Differential formation of prostacyclin (PGX or PGI2) by layers of the arterial wall. An explanation for the anti-thrombotic properties of vascular endothelium. Thromb Res 11:323–344
Moncada S, Vane JR (1979) Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2 and prostacyclin. Pharmacol Rev 30:293–331
Morikawa K, Matoba T, Kubota H, Hatanaka M, Fujiki T, Takahashi S, Takeshita A, Shimokawa H (2005) Influence of diabetes mellitus, hypercholesterolemia, and their combination on EDHF-mediated responses in mice. J Cardiovasc Pharmacol 45:485–490
Morrow JD, Hill KE, Burk RF, Nannour TM, Badr KF, Roberts LJ II (1990) A series of prostaglandins F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical catalysed mechanism. Proc Natl Acad Sci U S A 87:9383–9387
Nacci C, Tarquinio M, De Benedictis L, Mauro A, Zigrino A, Carratù MR, Quon MJ, Montagnani M (2009) Endothelial dysfunction in mice with streptozotocin-induced type 1 diabetes is opposed by compensatory overexpression of cyclooxygenase-2 in the vasculature. Endocrinology 150:849–861
Nakahata N (2008) Thromboxane A2: physiology/pathophysiology, cellular signal transduction and pharmacology. Pharmacol Ther 118:18–35
Numaguchi Y, Harada M, Osanai H, Hayashi K, Toki Y, Okamura K, Ito T, Hayakawa T (1999) Altered gene expression of prostacyclin synthase and prostacyclin receptor in the thoracic aorta of spontaneously hypertensive rats. Cardiovasc Res 41:682–688
O’Banion MK, Winn VD, Young DA (1992) cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase. Proc Natl Acad Sci U S A 89:4888–4892
Onodera M, Morita I, Mano Y, Murota S (2000) Differential effects of nitric oxide on the activity of prostaglandin endoperoxide H synthase-1 and -2 in vascular endothelial cells. Prostaglandins Leukot Essent Fatty Acids 62:161–167
Radomski MW, Palmer RMJ, Moncada S (1987) Comparative pharmacology of endothelium-derived relaxing factor, nitric oxide and prostacyclin in platelets. Br J Pharmacol 92:181–187
Radomski MW, Palmer RMJ, Moncada S (1987) The anti-aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide. Br J Pharmacol 92:639–646
Rapoport RM, Williams SP (1996) Role of prostaglandins in acetylcholine-induced contraction of aorta from spontaneously hypertensive and Wistar-Kyoto rats. Hypertension 28:64–75
Rovati GE, Sala, A, Capra V, Dahlen SE, Folco G. (2010) Dual COXIB/TP antagonists: a possible new twist in NASID pharmacology and cardiovascular risk. Trends Pharmacol Sci 31:102–107
Rubanyi GM, Vanhoutte PM (1986) Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor. Am J Physiol 250:H222–H227
Shi Y, Feletou M, Ku DD, Man RYK, Vanhoutte PM (2007) The calcium ionophore A23187 induces endothelium-dependent contractions in femoral arteries from rats with streptozotocin-induced diabetes. Br J Pharmacol 150:624–632
Shi Y, Man RY, Vanhoutte PM (2008) Two isoforms of cyclooxygenase contribute to augmented endothelium-dependent contractions in femoral arteries of 1-year-old rats. Acta Pharmacol Sin 29:185–192
Shimizu K, Muramatsu M, Kakegawa Y, Asano H, Toki Y, Miyazaki Y, Okumura K, Hashimoto H, Ito T (1993) Role of prostaglandin H2 as an endothelium-derived contracting factor in diabetic state. Diabetes 42:1246–1252
Smith WL, Marnett LJ (1991) Prostaglandin endoperoxide synthase: structure and catalysis. Biochem Biophys Acta 1083:1–17
Suzuki YJ, Ford GD (1992) Superoxide stimulates IP3-induced Ca2+ release from vascular smooth muscle sarcoplasmic reticulum. Am J Physiol 262:H114–H116
Taddei S, Vanhoutte PM (1993) Role of endothelium in endothelin-evoked contractions in the rat aorta. Hypertension 21:9–15
Taddei S, Virdis A, Ghiadoni L, Magagna A, Salvetti A (1997) Cyclooxygenase inhibition restores nitric oxide activity in essential hypertension. Hypertension 29:274–279
Taddei S, Virdis A, Mattei P, Ghiadoni L, Fasolo CB, Sudano I, Salvetti A (1997) Hypertension causes premature aging of endothelial function in humans. Hypertension 29:736–743
Taddei S, Virdis A, Mattei P, Ghiadoni L, Gennari A, Fasolo CB, Sudano I, Salvetti A (1995) Aging and endothelial function in normotensive subjects and patients with essential hypertension. Circulation 91:1981–1987
Tang EH, Ku DD, Tipoe GL, Félétou M, Man RY, Vanhoutte PM (2005) Endothelium-dependent contractions occur in the aorta of wild-type and COX2-/- knockout but not COX1-/- knockout mice. J Cardiovasc Pharmacol 46:761–765
Tang EH, Leung FP, Huang Y, Félétou M, So KF, Man RY, Vanhoutte PM (2007) Calcium and reactive oxygen species increase in endothelial cells in response to releasers of endothelium-derived contracting factor. Br J Pharmacol 151:15–23
Tang EH, Vanhoutte PM (2008) Gene expression changes of prostanoid synthases in endothelial cells and prostanoid receptors in vascular smooth muscle cells caused by aging and hypertension. Physiol Genomics 32:409–418
Tesfamariam B, Brown ML, Cohen RA (1995) 15-Hydroxyeicosatetraenoic acid and diabetic endothelial dysfunction in rabbit aorta. J Cardiovasc Pharmacol 25:748–755
Topper JN, Cai J, Falb D, Gimbrone MA Jr (1996) Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress. Proc Natl Acad Sci U S A 93:10417–10422
Tsuboi K, Sugimoto Y, Ichikawa A (2002) Prostanoid receptor subtypes. Prostaglandins Other Lipid Mediat 68–69:535–556
Valentin F, Field MC, Tippins JR (2004) The mechanism of oxidative stress stabilization of the thromboxane receptor in COS-7 cells. J Biol Chem 279:8316–8324
Van Diest MJ, Verbeuren TJ, Herman AG (1991) 15-lipoxygenase metabolites of arachidonic acid evoke contractions and relaxations in isolated canine arteries: role of thromboxane receptors, endothelial cells and cyclooxygenase. J Pharmacol Exp Ther 256:194–203
Vane J, Bakhle YS, Botting RM (1998) Cyclooxygenases 1 and 2. Annu Rev Pharmacol Toxicol 38:97–120
Vanhoutte PM, Félétou M, Taddei S (2005) Endothelium-dependent contractions in hypertension. Br J Pharmacol 144:449–458
Verbeuren TJ (2006) Terutroban and endothelial TP receptors in atherogenesis. Med Sci (Paris) 22:437–443
Virdis A, Colucci R, Versari D, Ghisu N, Fornai M, Antonioli L, Duranti E, Daghini E, Giannarelli C, Blandizzi C, Taddei S, Del Tacca M (2009) Atorvastatin prevents endothelial dysfunction in mesenteric arteries from spontaneously hypertensive rats: role of cyclooxygenase 2-derived contracting prostanoids. Hypertension 53:1008–1016
Watkins MT, Patton GM, Soler HM, Albadawi H, Humphries DE, Evans JE, Kadowaki K (1999) Synthesis of 8-epi-prostaglandinF2α by human endothelial cells: role of prostaglandin H2 synthase. Biochem J 344:747–775
Widlansky ME, Price DT, Gokce N, Eberhardt RT, Duffy SJ, Holbrook M, Maxwell C, Palmisano J, Keaney JF Jr, Morrow JD, Vita JA (2003) Short- and long-term COX-2 inhibition reverses endothelial dysfunction in patients with hypertension. Hypertension 42:310–315
Wilson SJ, Cavanagh CC, Lesher AM, Frey AJ, Russell SE, Smyth EM (2009) Activation-dependent stabilization of the human thromboxane receptor: role of reactive oxygen species. J Lipid Res 50:1047–1056
Wise H, Jones RL (1996) Focus on prostacyclin and its novel mimetics. Trends Pharmacol Sci 17:17–21
Wong MS, Man RY, Vanhoutte PM. (2010) Calcium-independent phospholipase A2 plays a key role in the endothelium-dependent contractions to acetylcholine in the aorta of SHR. Am J Physiol Heart Circ Physiol (in press)
Wong SL, Leung FP, Lau CW, Vanhoutte P, Huang Y (2008) Endothelium-dependent contractions in hamster aorta: the essential role of COX-2 and prostaglandin-2α. Basic Clin Pharmacol Toxicol 102(suppl 1):15–15
Wong SL, Leung FP, Lau CW, Au CL, Yung LM, Yao X, Chen ZY, Vanhoutte PM, Gollasch M, Huang Y (2009) Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging. Circ Res 104:228–235
Wotherspoon F, Browne DL, Meeking DR, Allard SE, Munday LJ, Shaw KM, Cummings MH (2005) The contribution of nitric oxide and vasodilatory prostanoids to bradykinin-mediated vasodilation in Type 1 diabetes. Diabet Med 22:697–702
Xavier FE, Aras-López R, Arroyo-Villa I, Campo LD, Salaices M, Rossoni LV, Ferrer M, Balfagón G (2008) Aldosterone induces endothelial dysfunction in resistance arteries from normotensive and hypertensive rats by increasing thromboxane A2 and prostacyclin. Br J Pharmacol 154:1225–1235
Yang D, Félétou M, Boulanger CM, Wu HF, Levens N, Zhang JN, Vanhoutte PM (2002) Oxygen-derived free radicals mediate endothelium-dependent contractions to acetylcholine in aortas from spontaneously hypertensive rats. Br J Pharmacol 136:104–110
Yang D, Félétou M, Levens N, Zhang JN, Vanhoutte PM (2003) A diffusible substance(s) mediates endothelium-dependent contractions in the aorta of SHR. Hypertension 41:143–148
Yang D, Levens N, Zhang JN, Vanhoutte PM, Félétou M (2003) Specific potentiation of endothelium-dependent contractions in SHR by tetrahydrobiopterin. Hypertension 41:136–142
Yang D, Gluais P, Zhang JN, Vanhoutte PM, Félétou M (2004) Endothelium-dependent contractions to acetylcholine, ATP and the calcium ionophore A 23187 in aortas from spontaneously hypertensive and normotensive rats. Fundam Clin Pharmacol 18:321–326
Yokohama C, Takai T, Tanabe T (1988) Primary structure of sheep prostaglandin endoperoxide synthase deduced from cDNA sequence. FEBS Lett 231:347–351
Zerrouk A, Auguet M, Chabrier PE (1998) Augmented endothelium-dependent contraction to angiotensin II in the SHR aorta: role of an inducible cyclooxygenase metabolite. J Cardiovasc Pharmacol 31:525–533
Zhou Y, Mitra S, Varadharaj S, Parinandi N, Zweier JL, Flavahan NA (2006) Increased expression of cyclooxygenase-2 mediates enhanced contraction to endothelin ETA receptor stimulation in endothelial nitric oxide synthase knockout mice. Circ Res 98:1439–1445
Zou MH, Shi C, Cohen RA (2002) High glucose via peroxynitrite causes tyrosine nitration and inactivation of prostacyclin synthase that is associated with thromboxane/prostaglandin H(2) receptor-mediated apoptosis and adhesion molecule expression in cultured human aortic endothelial cells. Diabetes 51:198–203
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Félétou, M., Huang, Y. & Vanhoutte, P.M. Vasoconstrictor prostanoids. Pflugers Arch - Eur J Physiol 459, 941–950 (2010). https://doi.org/10.1007/s00424-010-0812-6
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DOI: https://doi.org/10.1007/s00424-010-0812-6