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Understanding inflammatory pain: ion channels contributing to acute and chronic nociception

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Abstract

Inflammatory pain results from the increased excitability of peripheral nociceptive sensory fibres produced by the action of inflammatory mediators. This excitatory effect, in turn, is a result of the altered activity of ion channels within affected sensory fibres. This review will consider the molecular consequences of inflammation within the peripheral nerves with particular focus on the effects of different inflammatory mediators on the ion channels in sensory neurons. We will discuss the main signalling pathways triggered in neurons by inflammatory mediators; the ionic mechanisms underlying inflammatory hyperalgesia and spontaneous inflammatory pain and finally will briefly consider ion channels underlying pain in chronic inflammation.

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Acknowledgement

Research in our group is supported by the Wellcome Trust, MRC, BBSRC and the Royal Society.

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  1. Institute of Membrane and Systems Biology, Faculty of Biological Sciences, University of Leeds, LS2 9JT, Leeds, UK

    John E. Linley, Kirstin Rose, Lezanne Ooi & Nikita Gamper

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  1. John E. Linley
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Correspondence to Nikita Gamper.

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Linley, J.E., Rose, K., Ooi, L. et al. Understanding inflammatory pain: ion channels contributing to acute and chronic nociception. Pflugers Arch - Eur J Physiol 459, 657–669 (2010). https://doi.org/10.1007/s00424-010-0784-6

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