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Cardiac thin filament regulation

  • Cardiovascular Physiology
  • Published:
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Abstract

Myocardial contraction is initiated upon the release of calcium into the cytosol from the sarcoplasmic reticulum following membrane depolarization. The fundamental physiological role of the heart is to pump an amount blood that is determined by the prevailing requirements of the body. The physiological control systems employed to accomplish this task include regulation of heart rate, the amount of calcium release, and the response of the cardiac myofilaments to activator calcium ions. Thin filament activation and relaxation dynamics has emerged as a pivotal regulatory system tuning myofilament function to the beat-to-beat regulation of cardiac output. Maladaptation of thin filament dynamics, in addition to dysfunctional calcium cycling, is now recognized as an important cellular mechanism causing reduced cardiac pump function in a variety of cardiac diseases. Here, we review current knowledge regarding protein–protein interactions involved in the dynamics of thin filament activation and relaxation and the regulation of these processes by protein kinase-mediated phosphorylation.

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Acknowledgments

Much of our own data discussed in this review were derived from experiments that would not have been possible without the strong collaborative environment that exist within the center for cardiovascular research at UIC. Furthermore, we apologize that were not able, due to space limitations, to include many references to excellent works published by our colleagues in the field. Supported, in part, by grants from the American Heart Association and NIH grants HL62426, HL75494, HL77195, HL082923, HL22231, HL73828, HL07692, and HL072742.

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  1. Center for Cardiovascular Research, Department of Physiology & Biophysics, University of Illinois at Chicago, Chicago, IL, 60612, USA

    Tomoyoshi Kobayashi, Lei Jin & Pieter P. de Tombe

  2. Department of Physiology & Biophysics, University of Illinois at Chicago, 835 S. Wolcott (M/C 901), Chicago, IL, 60612, USA

    Pieter P. de Tombe

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  1. Tomoyoshi Kobayashi
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Kobayashi, T., Jin, L. & de Tombe, P.P. Cardiac thin filament regulation. Pflugers Arch - Eur J Physiol 457, 37–46 (2008). https://doi.org/10.1007/s00424-008-0511-8

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