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Regulation of ATP-gated P2X receptors by phosphoinositides

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Abstract

Phosphoinositides are minor membrane lipids involved in many cellular signaling processes. The addition or removal of phosphates on phosphoinositides depends on the interplay of specific lipid kinases and phosphatases. P2X receptors are cation channels that are gated by extracellular ATP. They play multiple and important physiological roles in vertebrates, ranging from pain sensation and control of smooth muscle contraction to cytokine release and immune cell death. In this article, we review recent studies that have identified phosphoinositides as critical modulators of P2X receptor function.

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Authors and Affiliations

  1. Department of Structural and Chemical Biology, Mount Sinai School of Medicine of New York University, New York, NY, 10029, USA

    Qi Zhao & Diomedes E. Logothetis

  2. Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, 3801 University, Montreal, QC, H3A 2B4, Canada

    Philippe Séguéla

Authors
  1. Qi Zhao
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  2. Diomedes E. Logothetis
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  3. Philippe Séguéla
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Correspondence to Philippe Séguéla.

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Zhao, Q., Logothetis, D.E. & Séguéla, P. Regulation of ATP-gated P2X receptors by phosphoinositides. Pflugers Arch - Eur J Physiol 455, 181–185 (2007). https://doi.org/10.1007/s00424-007-0271-x

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  • DOI: https://doi.org/10.1007/s00424-007-0271-x

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