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Calcium-dependent transcription of cytokine genes in T lymphocytes

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Abstract

The increase in intracellular calcium ion concentration is a general signaling mechanism used in many biological systems. In T lymphocytes, calcium is essential for activation, differentiation, and effector functions. In this study, we will summarize recent developments of how intracellular calcium concentrations are modified in T cells to affect the activity of three major calcium-dependent transcriptional effectors, i.e., NFAT, MEF2, and DREAM, involved in cytokine gene expression.

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Abbreviations

AKAP-79:

A-kinase anchoring protein-79

AP1:

activator protein-1

[Ca2+]i :

intracellular calcium concentration

Ca2+ :

calcium

CaMK:

calmodulin kinase

cAMP:

cyclic AMP

cGMP:

cyclic GMP

CIF:

calcium influx factor

CK:

casein kinase

CN:

calcineurin

CRAC:

calcium release-activated Ca2+ channels

CREM:

cAMP-response element modulator

CsA:

cyclosporin A

DHPR:

dihydropyridine receptors

DRE:

downstream regulatory element

DREAM:

downstream regulatory element antagonist modulator

DSCR/MCIP:

Down’s syndrome critical region/modulatory calcineurin-interacting protein

DYRK:

dual-specificity tyrosine-phosphorylation regulated kinases

EGR-1:

early growth response protein

ER:

endoplasmic reticulum

FOXP:

forkhead box protein

GM-CSF:

granulocyte-macrophage colony-stimulating factor

GSK:

glycogen synthase kinase

HDAC:

histone deacetylase

IFN:

interferon

IL:

interleukin

IP3:

inositol-1,4,5-triphosphate

IRF4:

interferon regulatory factor 4

JNK1:

c-Jun N-terminal kinase

KchIP:

K+ channel interacting protein

LTCC:

L-type calcium channels

MAPkinase:

mitogen-activated protein kinase

MEF:

myocyte enhancer factor

MITR:

MEF2 interacting transcriptional repressor

MHC:

major histocompatibility complex

NFAT:

nuclear factor of activated T cells

NIP-45:

NFAT–interacting protein

PI3 kinase:

phosphatidylinositol 3 kinase

PLCγ:

phospholipase Cγ

TCR:

T-cell receptor

Th:

T helper

Treg:

regulatory T

TRP:

transient receptor potential channel

SOC:

store-operated channels

STAT:

signal transducer and activator of transcription

STIM:

stromal interacting molecule

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Acknowledgements

Magali Savignac and Britt Mellström are supported by the Ramon y Cajal Senior Scientist Contracts. The work in our laboratory is supported by grants from the Human Frontiers Science Program, CEE, Fundacion La Caixa, MEC, FISS and CAM.

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  1. Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Cientificas, Madrid, Spain

    Magali Savignac, Britt Mellström & Jose R. Naranjo

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  1. Magali Savignac
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  2. Britt Mellström
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  3. Jose R. Naranjo
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Correspondence to Jose R. Naranjo.

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Savignac, M., Mellström, B. & Naranjo, J.R. Calcium-dependent transcription of cytokine genes in T lymphocytes. Pflugers Arch - Eur J Physiol 454, 523–533 (2007). https://doi.org/10.1007/s00424-007-0238-y

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  • DOI: https://doi.org/10.1007/s00424-007-0238-y

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