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Na+ entry and modulation of Na+/Ca2+ exchange as a key mechanism of TRPC signaling

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Abstract

Ion channels formed by canonical transient receptor potential (TRPC) proteins are considered to be key players in cellular Ca2+ homeostasis. As permeation of Ca2+ through TRPC homo- and/or heteromeric channels has been repeatedly demonstrated, analysis of the physiological role of TRPC proteins was so far based on the concept that these proteins form regulated Ca2+ entry channels. The well-recognized lack of cation selectivity of TRPC channels and the ability to generate substantial monovalent conductances that govern membrane potential and cation gradients were barely appreciated as a physiologically relevant issue. Nonetheless, recent studies suggest monovalent, specifically Na+ permeation through TRPC cation channels as an important event in TRPC signaling. TRPC-mediated Na+ entry may be converted into a distinct pattern of cellular Ca2+ signals by interaction with Na+/Ca2+ exchanger proteins. This review discusses current concepts regarding the link between Na+ entry through TRPC channels and cellular Ca2+ signaling.

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Acknowledgments

Supported by the Fonds zur Förderung der wissenschaftlichen Forschung in Austria

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Authors and Affiliations

  1. Institute of Pharmaceutical Sciences, Pharmacology and Toxicology, Karl-Franzens-University of Graz, Universitaetsplatz 2, 8010, Graz, Austria

    Petra Eder, Michael Poteser & Klaus Groschner

  2. Institute of Biophysics, University of Linz, 4020, Linz, Austria

    Christoph Romanin

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  1. Petra Eder
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  2. Michael Poteser
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  3. Christoph Romanin
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  4. Klaus Groschner
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Correspondence to Klaus Groschner.

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Eder, P., Poteser, M., Romanin, C. et al. Na+ entry and modulation of Na+/Ca2+ exchange as a key mechanism of TRPC signaling. Pflugers Arch - Eur J Physiol 451, 99–104 (2005). https://doi.org/10.1007/s00424-005-1434-2

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  • DOI: https://doi.org/10.1007/s00424-005-1434-2

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