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TRPV5 and TRPV6 in Ca2+ (re)absorption: regulating Ca2+ entry at the gate

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Abstract

Many physiological functions rely on the exact maintenance of body Ca2+ balance. Therefore, the extracellular Ca2+ concentration is tightly regulated by the concerted actions of intestinal Ca2+ absorption, exchange of Ca2+ to and from bone, and renal Ca2+ reabsorption. Renal distal convoluted and connecting tubular cells as well as duodenal epithelial cells are unique in their ability to mediate transcellular (re)absorption of Ca2+ at large and highly variable rates. Two members of the transient receptor potential (TRP) superfamily, TRP vanilloid (TRPV)5 and TRPV6, are specialized epithelial Ca2+ channels responsible for the critical Ca2+ entry step in transcellular Ca2+ (re)absorption in intestine and kidney, respectively. Because transcellular Ca2+ transport is fine-tuned to the body’s specific requirements, regulation of the transmembrane Ca2+ flux through TRPV5/6 is of particular importance and has, therefore, to be conspicuously controlled. We present an overview of the current knowledge and recent advances concerning the coordinated regulation of Ca2+ influx through the epithelial Ca2+ channels TRPV5 and TRPV6 in transcellular Ca2+ (re)absorption.

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Authors and Affiliations

  1. Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500, HB Nijmegen, The Netherlands

    Tom Nijenhuis, Joost G. J. Hoenderop & René J. M. Bindels

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  1. Tom Nijenhuis
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  2. Joost G. J. Hoenderop
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  3. René J. M. Bindels
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Correspondence to René J. M. Bindels.

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Nijenhuis, T., Hoenderop, J.G.J. & Bindels, R.J.M. TRPV5 and TRPV6 in Ca2+ (re)absorption: regulating Ca2+ entry at the gate. Pflugers Arch - Eur J Physiol 451, 181–192 (2005). https://doi.org/10.1007/s00424-005-1430-6

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  • DOI: https://doi.org/10.1007/s00424-005-1430-6

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