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Multiple roles of calmodulin and other Ca2+-binding proteins in the functional regulation of TRP channels

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Abstract

Transient receptor potential channels (TRP) have emerged as cellular sensors of various internal and external cues. Generally, the activation of TRP canonical (TRPC) channels is triggered by the stimulation of phospholipase C; however, multiple factors are involved in the regulation of these channels. Among them, Ca2+-mediated feedback channel modulations are often mediated by calmodulin (CaM) and other Ca2+-binding proteins. In vitro binding studies have revealed multiple CaM-binding sites on TRPC proteins. Among them, a common CaM/inositol 1,4,5-trisphosphate receptor-binding site is found at the carboxyl terminus of every TRPC isoform. Additional non-conserved CaM-binding sites are present at the amino and carboxyl termini of several TRPC proteins. Likewise, multiple CaM-binding sites were found in other TRP proteins. These, together with the presence in close vicinity of the interaction sites for the related neuronal Ca2+-binding proteins, such as CaBP1, suggest a multitude of diverse intracellular Ca2+-dependent regulations of TRP channels. Functional studies have begun to reveal the unique roles of CaM and CaBP1 binding to several TRP channels. This review will focus on the CaM- and CaBP1-mediated regulations of TRPC channels. Related studies on TRPM and TRPV channels will also be highlighted.

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Acknowledgements

The author wishes to thank Drs. Jisen Tang and Mariko Kinoshita-Kawaka for their excellent experimental work; Drs. Indu Ambudkar, Bernd Nilius, and Luis Vaca for collaborations; and the US National Institutes of Health (grant NS42183) for support.

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  1. Department of Neuroscience and the Center for Molecular Neurobiology, The Ohio State University, 168 Rightmire Hall, 1060 Carmack Road, Columbus, OH, 43210, USA

    Michael Xi Zhu

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Correspondence to Michael Xi Zhu.

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Zhu, M.X. Multiple roles of calmodulin and other Ca2+-binding proteins in the functional regulation of TRP channels. Pflugers Arch - Eur J Physiol 451, 105–115 (2005). https://doi.org/10.1007/s00424-005-1427-1

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  • DOI: https://doi.org/10.1007/s00424-005-1427-1

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