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The SLC40 basolateral iron transporter family (IREG1/ferroportin/MTP1)

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  • Guest Editor: Matthias A. Hediger
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Abstract

The iron regulated-transporter-1 (Ireg1, also known as ferroportin or metal transporter protein-1, MTP1) appears to be the sole member of the SLC40 transporter family. It functions as a universal efflux pathway for iron in a number of cell types. The protein is most highly expressed in mature enterocytes of the duodenum, in syncytiotrophoblasts, which separate foetal and maternal circulations in the placenta, and in macrophages responsible for recycling iron from breakdown of aged red blood cells.

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Acknowledgements

The authors wish to thank R.J. Simpson for critical reading of the manuscript. The authors gratefully acknowledge funding from the MRC, HSFP, NIH and the EU. ATM is an MRC Career Development Fellow.

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Authors and Affiliations

  1. Division of Life Sciences, Kings College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NN, UK

    Andrew T McKie

  2. Department of Pharmacy, Kings College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NN, UK

    David J Barlow

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Correspondence to Andrew T McKie.

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McKie, A.T., Barlow, D.J. The SLC40 basolateral iron transporter family (IREG1/ferroportin/MTP1). Pflugers Arch - Eur J Physiol 447, 801–806 (2004). https://doi.org/10.1007/s00424-003-1102-3

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  • DOI: https://doi.org/10.1007/s00424-003-1102-3

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