The epithelial calcium channels TRPV5 and TRPV6 have been studied extensively in the epithelial tissues controlling Ca2+ homeostasis and exhibit a range of distinctive properties that distinguish them from other transient receptor potential (TRP) channels. These two novel members of the superfamily of TRP channels were cloned from vitamin D-responsive epithelia: kidney, small intestine and placenta, and identified subsequently in tissues like pancreas, bone and prostate. This review addresses the unique properties of these highly Ca2+-selective channels and highlights their implications for the process of transepithelial Ca2+ transport.
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Hoenderop, J., Nilius, B. & Bindels, R. Epithelial calcium channels: from identification to function and regulation. Pflugers Arch - Eur J Physiol 446, 304–308 (2003). https://doi.org/10.1007/s00424-003-1045-8
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DOI: https://doi.org/10.1007/s00424-003-1045-8