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Effects of indocyanine green fluorescence imaging of laparoscopic anatomic liver resection for HCC: a propensity score-matched study

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Abstract

Background

Recently, indocyanine green (ICG) fluorescence imaging has been increasingly used in laparoscopic anatomic liver resection. The aim of this study was to investigate the efficacy of ICG-guided laparoscopic anatomic liver resection in hepatocellular carcinoma (HCC) compared with traditional laparoscopic anatomic liver resection.

Methods

A retrospective study was performed on patients with pathologically diagnosed HCC who successfully underwent laparoscopic anatomical liver resection from January 2019 to December 2021. The outcomes were compared between the two groups before and after the propensity score matching (PSM).

Results

A total of 110 patients were included in this study, including 50 patients in the ICG-guided group and 60 patients in the traditional group. Compared with the traditional group, the ICG-guided group had a shorter operative duration (P = 0.040), less intraoperative blood loss (P = 0.044), a lower incidence of postoperative complications (P = 0.023), and a shorter postoperative hospitalisation (P < 0.001). After PSM, significant differences remained between the two groups for the duration of postoperative hospitalisation (P = 0.018) and postoperative complications (P = 0.042). There was no significant difference in the recurrence rate between the two groups before and after PSM.

Conclusion

Laparoscopic anatomic liver resection guided by ICG fluorescence imaging can reduce the duration of postoperative hospitalisation for patients and the incidence of postoperative complications. However, it has no impact on the long-term outcome of patients.

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Data Availability

The data that support the findings of this study are available from the corresponding author, [JinLiang Ma], upon reasonable request.

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Acknowledgements

We would like to acknowledge AJE Digital Editing for its linguistic assistance during the preparation of this manuscript.

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Author notes

  1. Yi Zhou and Chuanhai Zhang contributed equally to this manuscript.

Authors and Affiliations

  1. Department of Hepatic Surgery, Anhui Provincial Hospital Affiliated to Anhui Medical University, Anhui Province, Hefei, 230001, China

    Yi Zhou, Yifan Wang & Jinliang Ma

  2. Department of Hepatic Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, China

    Chuanhai Zhang & Jihai Yu

  3. Department of Intensive Care Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, China

    Di Wang

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  1. Yi Zhou
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  4. Jihai Yu
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  5. Di Wang
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Contributions

Study conception and design: Yi Zhou, Chuanhai Zhang, Yifan Wang, Jihai Yu, Di Wang, and Jinliang Ma. Analysis and interpretation of data: Yi Zhou, Chuanhai Zhang, Yifan Wang, and Jinliang Ma. Drafting of manuscript: Yi Zhou. Critical revision of manuscript: Yi Zhou, Chuanhai Zhang, Yifan Wang, Jihai Yu, Di Wang, and Jinliang Ma. All authors have read and approved the final manuscript.

Corresponding author

Correspondence to Jinliang Ma.

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Ethics approval and consent to participate

The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. All of the experimental procedures were performed under a project license (No.: 2022-RE-008) granted by the institutional ethics board of The First Affiliated Hospital of USTC (Hefei, China).

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Zhou, Y., Zhang, C., Wang, Y. et al. Effects of indocyanine green fluorescence imaging of laparoscopic anatomic liver resection for HCC: a propensity score-matched study. Langenbecks Arch Surg 408, 51 (2023). https://doi.org/10.1007/s00423-023-02781-z

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