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Implication of visceral obesity in patients with esophageal squamous cell carcinoma

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Abstract

Purpose

Visceral obesity is considered to be associated not only with chronic systemic inflammation but also with aggressive cancer behavior. However, the implication of visceral obesity in patients with esophageal squamous cell carcinoma (ESCC) is unclear.

Methods

Computed tomography volumetry was performed in 364 patients who underwent esophagectomy for ESCC. We calculated the ratio of the visceral fat area to the subcutaneous fat area (VS ratio), which is a valuable parameter of visceral obesity. Then, the clinicopathological characteristics were compared between patients with low VS ratio and those with high VS ratio.

Results

Overall and disease-specific survivals of patients with high VS ratio were significantly worse than those with low VS ratio (P < 0.001 in both). Patients with high VS ratio had considerably more advanced pN factor, higher prevalence of lymphatic invasion, and more number of metastatic lymph nodes than those with low VS ratio (P = 0.044, < 0.001, and 0.006, respectively). Among patients who received preoperative treatment, high VS ratio correlated with poor response to preoperative treatment (P = 0.040).

Conclusions

Visceral obesity was associated with lymphatic invasiveness and poor response to preoperative treatment in patients with ESCC, which may negatively influence their prognosis.

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Funding

This work was supported in part by the Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Scientific Research (M.W. grant number 15K10122).

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Authors and Affiliations

  1. Department of Gastroenterological Surgery, Gastroenterology Center, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3–8–31 Ariake, Koto–ku, Tokyo, 135–8550, Japan

    Akihiko Okamura, Masayuki Watanabe, Kotaro Yamashita, Masami Yuda, Masaru Hayami & Shinji Mine

Authors
  1. Akihiko Okamura
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  2. Masayuki Watanabe
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  3. Kotaro Yamashita
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  4. Masami Yuda
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  5. Masaru Hayami
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  6. Yu Imamura
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  7. Shinji Mine
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Contributions

Study conception and design: all authors. Acquisition of data: all authors. Analysis and interpretation of data: Okamura, Watanabe, Yamashita, Yuda, Mine. Drafting manuscript: Okamura, Watanabe, Hayami, Imamura. Critical revision of manuscript: all authors.

Corresponding author

Correspondence to Masayuki Watanabe.

Ethics declarations

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study. This article does not contain any studies with animals performed by any of the authors.

Conflicts of interest

The authors declare that they have no conflicts of interest.

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Okamura, A., Watanabe, M., Yamashita, K. et al. Implication of visceral obesity in patients with esophageal squamous cell carcinoma. Langenbecks Arch Surg 403, 245–253 (2018). https://doi.org/10.1007/s00423-017-1643-0

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  • DOI: https://doi.org/10.1007/s00423-017-1643-0

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