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Management of persistent postsurgical inguinal pain

  • Review Article
  • Published:
Langenbeck's Archives of Surgery Aims and scope Submit manuscript

Abstract

Purpose

Severe persistent pain is a major postsurgical complication affecting 2–4 % of patients following inguinal hernia repair and may cause critical physical and socioeconomic disability. This review introduces relevant criteria and analyses the current evidence base underlying recommended management strategies.

Results

Development of persistent postsurgical pain (PPP) following inguinal hernia repair cannot automatically be considered to follow a simple trajectory from acute to chronic pain. Surgical management comprising neurectomy with or without meshectomy was described in 25 studies. Local anesthetic blocks, pharmacological management, and treatment with sensory stimulation methods were presented in seven studies. In spite of shortcomings, the data on surgical management demonstrate that neurectomy with or without mesh removal may provide long-lasting analgesic effects in most patients with severe PPP following inguinal hernia repair. The evidence base for other management methods is still fragile, although promising results appear in the neuromodulation studies.

Conclusions

There is a need for improved study designs and, launching of large multicenter collaborative studies supplying the necessary long-term data for recommendation of future management strategies.

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Notes

  1. 2,000 inguinal hernia repairs per year per million inhabitants; population in Germany, 80 million.

  2. Calculated in studyi as: follow-up weeksi x (number of patientsi/total number of patients). Values for each study are summed up giving a weighted mean value.

  3. Calculated in studyi as: pain relief ratioi x (number of patientsi/total number of patients). Ratios for each study are summed up giving a weighted mean ratio.

References

  1. Werner MU, Bischoff JM (2014) Persistent postsurgical pain: evidence from breast cancer surgery, groin hernia repair, and lung cancer surgery. Curr Top Behav Neurosci. doi:10.1007/7854_2014_285

    PubMed  Google Scholar 

  2. Kehlet H, Roumen RM, Reinpold W, Miserez M (2013) Invited commentary: persistent pain after inguinal hernia repair: what do we know and what do we need to know? Hernia 17:293–297. doi:10.1007/s10029-013-1109-4

    Article  CAS  PubMed  Google Scholar 

  3. Macrae WA, Davies HTO (1999) Chronic postsurgical pain. In: Crombie IK, Linton S, Von Korff M, LeResche L (eds) Epidemiology of pain. IASP Press, Seattle, pp 125–142

    Google Scholar 

  4. Macrae WA (2001) Chronic pain after surgery. Br J Anaesth 87:88–98

    Article  CAS  PubMed  Google Scholar 

  5. Kehlet H, Macrae WA, Stubhaug A (2010) Persistent postoperative pain pathogenic mechanisms and preventive strategies. In: Mogil JS (ed) Pain 2010. An updated review: refresher course syllabus. IASP Press, Seattle, pp 3–12

    Google Scholar 

  6. Kehlet H, Edwards RR, Buvanendran A (2012) Persistent postoperative pain: pathogenic mechanisms and preventive strategies. In: Tracey I (ed). Pain 2012. Refresher courses. 14th World Congress of Pain. Seattle: IASP Press, pp 133–146

  7. Werner MU, Kongsgaard UE (2014) Defining persistent post-surgical pain: is an update required? Br J Anaesth (E-preprint)

  8. Aasvang EK, Hansen JB, Kehlet H (2009) Pre-operative pain and sensory function in groin hernia. Eur J Pain 13:1018–1022. doi:10.1016/j.ejpain.2008.11.015

    Article  PubMed  Google Scholar 

  9. Aasvang EK, Mohl B, Kehlet H (2007) Ejaculatory pain: a specific postherniotomy pain syndrome? Anesthesiology 107:298–304

    Article  PubMed  Google Scholar 

  10. Bischoff JM, Linderoth G, Aasvang EK, Werner MU, Kehlet H (2012) Dysejaculation after laparoscopic inguinal herniorrhaphy: a nationwide questionnaire study. Surg Endosc 26:979–983. doi:10.1007/s00464-011-1980-y

    Article  PubMed  Google Scholar 

  11. Bay-Nielsen M, Perkins FM, Kehlet H (2001) Pain and functional impairment one year after inguinal herniorrhaphy—a nationwide questionnaire study. Ann Surg 233:1–7

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  12. Poobalan AS, Bruce J, King PM, Chambers WA, Krukowski ZH, Smith WC (2001) Chronic pain and quality of life following open inguinal hernia repair. Br J Surg 88:1122–1126

    Article  CAS  PubMed  Google Scholar 

  13. Mikkelsen T, Werner MU, Lassen B, Kehlet H (2004) Pain and sensory dysfunction 6 to 12 months after inguinal herniotomy. Anesth Analg 99:146–151

    Article  PubMed  Google Scholar 

  14. Grant AM, Scott NW, O’Dwyer PJ (2004) Five-year follow-up of a randomized trial to assess pain and numbness after laparoscopic or open repair of groin hernia. Br J Surg 91:1570–1574

    Article  CAS  PubMed  Google Scholar 

  15. Aasvang EK, Bay-Nielsen M, Kehlet H (2006) Pain and functional impairment 6 years after inguinal herniorrhaphy. Hernia 10:316–321

    Article  CAS  PubMed  Google Scholar 

  16. Reinpold WM, Nehls J, Eggert A (2011) Nerve management and chronic pain after open inguinal hernia repair: a prospective two phase study. Ann Surg 254:163–168. doi:10.1097/SLA.0b013e31821d4a2d

    Article  PubMed  Google Scholar 

  17. Kehlet H, Jensen TS, Woolf CJ (2006) Persistent postsurgical pain: risk factors and prevention. Lancet 367:1618–1625

    Article  PubMed  Google Scholar 

  18. Borsook D, Kussman BD, George E, Becerra LR, Burke DW (2013) Surgically induced neuropathic pain: understanding the perioperative process. Ann Surg 257:403–412. doi:10.1097/SLA.0b013e3182701a7b

    Article  PubMed Central  PubMed  Google Scholar 

  19. Oken BS (2008) Placebo effects: clinical aspects and neurobiology. Brain 131:2812–2823. doi:10.1093/brain/awn116

    Article  PubMed Central  PubMed  Google Scholar 

  20. Goetz CG, Wuu J, McDermott MP, Adler CH, Fahn S, Freed CR, Hauser RA, Olanow WC, Shoulson I, Tandon PK, Leurgans S (2008) Placebo response in Parkinson’s disease: comparisons among 11 trials covering medical and surgical interventions. Mov Disord 23:690–699. doi:10.1002/mds.21894

    Article  PubMed  Google Scholar 

  21. Campillo A, Cabanero D, Romero A, Garcia-Nogales P, Puig MM (2011) Delayed postoperative latent pain sensitization revealed by the systemic administration of opioid antagonists in mice. Eur J Pharmacol 657:89–96. doi:10.1016/j.ejphar.2011.01.059

    Article  CAS  PubMed  Google Scholar 

  22. Corder G, Doolen S, Donahue RR, Winter MK, Jutras BL, He Y, Hu X, Wieskopf JS, Mogil JS, Storm DR, Wang ZJ, McCarson KE, Taylor BK (2013) Constitutive mu-opioid receptor activity leads to long-term endogenous analgesia and dependence. Science 341:1394–1399. doi:10.1126/science.1239403

    Article  CAS  PubMed  Google Scholar 

  23. Pereira MP, Werner MU, Ringsted TK, Rowboth MC, Taylor BK, Dahl JB (2013) Does naloxone reinstate secondary hyperalgesia in humans after resolution of a burn injury? A placebo-controlled, double-blind, randomized, cross-over study. PLoS One 8:e64608. doi:10.1371/journal.pone.0064608

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  24. Linderoth G, Kehlet H, Aasvang EK, Werner MU (2011) Neurophysiological characterization of persistent pain after laparoscopic inguinal hernia repair. Hernia 15:521–529. doi:10.1007/s10029-011-0815-z

    Article  CAS  PubMed  Google Scholar 

  25. Gottrup H, Andersen J, Arendt-Nielsen L, Jensen TS (2000) Psychophysical examination in patients with post-mastectomy pain. Pain 87:275–284

    Article  CAS  PubMed  Google Scholar 

  26. Aasvang EK, Brandsborg B, Christensen B, Jensen TS, Kehlet H (2008) Neurophysiological characterization of postherniotomy pain. Pain 137:173–181

    Article  PubMed  Google Scholar 

  27. Wildgaard K, Ringsted TK, Aasvang EK, Ravn J, Werner MU, Kehlet H (2012) Neurophysiological characterization of persistent postthoracotomy pain. Clin J Pain 28:136–142. doi:10.1097/AJP.0b013e3182261650

    Article  PubMed  Google Scholar 

  28. Aasvang EK, Brandsborg B, Jensen TS, Kehlet H (2010) Heterogeneous sensory processing in persistent postherniotomy pain. Pain 150:237–242

    Article  PubMed  Google Scholar 

  29. Amid PK (2004) Causes, prevention, and surgical treatment of postherniorrhaphy neuropathic inguinodynia: triple neurectomy with proximal end implantation. Hernia 8:343–349. doi:10.1007/s10029-004-0247-0

    Article  CAS  PubMed  Google Scholar 

  30. Loos MJ, Roumen RM, Scheltinga MR (2007) Classifying post-herniorrhaphy pain syndromes following elective inguinal hernia repair. World J Surg 31:1760–1765. doi:10.1007/s00268-007-9121-4

    Article  CAS  PubMed  Google Scholar 

  31. Campanelli G, Bertocchi V, Cavalli M, Bombini G, Biondi A, Tentorio T, Sfeclan C, Canziani M (2013) Surgical treatment of chronic pain after inguinal hernia repair. Hernia 17:347–353. doi:10.1007/s10029-013-1059-x

    Article  CAS  PubMed  Google Scholar 

  32. Suarez JC, Ely EE, Mutnal AB, Figueroa NM, Klika AK, Patel PD, Barsoum WK (2013) Comprehensive approach to the evaluation of groin pain. J Am Acad Orthop Surg 21:558–570. doi:10.5435/JAAOS-21-09-558

    Article  PubMed  Google Scholar 

  33. Starling JR, Harms BA, Schroeder ME, Eichman PL (1987) Diagnosis and treatment of genitofemoral and ilioinguinal entrapment neuralgia. Surgery 102:581–586

    CAS  PubMed  Google Scholar 

  34. Starling JR, Harms BA (1989) Diagnosis and treatment of genitofemoral and ilioinguinal neuralgia. World J Surg 13:586–591

    Article  CAS  PubMed  Google Scholar 

  35. Bower S, Moore BB, Weiss SM (1996) Neuralgia after inguinal hernia repair. Am Surg 62:664–667

    CAS  PubMed  Google Scholar 

  36. Heise CP, Starling JR (1998) Mesh inguinodynia: a new clinical syndrome after inguinal herniorrhaphy? J Am Coll Surg 187:514–518

    Article  CAS  PubMed  Google Scholar 

  37. Lee CH, Dellon AL (2000) Surgical management of groin pain of neural origin. J Am Coll Surg 191:137–142

    Article  CAS  PubMed  Google Scholar 

  38. Deysine M, Deysine GR, Reed WP Jr (2002) Groin pain in the absence of hernia: a new syndrome. Hernia 6:64–67

    Article  CAS  PubMed  Google Scholar 

  39. Amid PK (2002) A 1-stage surgical treatment for postherniorrhaphy neuropathic pain: triple neurectomy and proximal end implantation without mobilization of the cord. Arch Surg 137:100–104

    PubMed  Google Scholar 

  40. Madura JA, Madura JA, Copper CM, Worth RM (2005) Inguinal neurectomy for inguinal nerve entrapment: an experience with 100 patients. Am J Surg 189:283–287. doi:10.1016/j.amjsurg.2004.11.015

    Article  PubMed  Google Scholar 

  41. Kim DH, Murovic JA, Tiel RL, Kline DG (2005) Surgical management of 33 ilioinguinal and iliohypogastric neuralgias at Louisiana State University Health Sciences Center. Neurosurgery 56:1013–1020

    Article  PubMed  Google Scholar 

  42. Rosen MJ, Novitsky YW, Cobb WS, Kercher KW, Heniford BT (2006) Combined open and laparoscopic approach to chronic pain following open inguinal hernia repair. Hernia 10:20–24. doi:10.1007/s10029-005-0032-8

    Article  CAS  PubMed  Google Scholar 

  43. Amid PK, Hiatt JR (2007) New understanding of the causes and surgical treatment of postherniorrhaphy inguinodynia and orchalgia. J Am Coll Surg 205:381–385. doi:10.1016/j.jamcollsurg.2007.04.001

    Article  PubMed  Google Scholar 

  44. Keller JE, Stefanidis D, Dolce CJ, Iannitti DA, Kercher KW, Heniford BT (2008) Combined open and laparoscopic approach to chronic pain after inguinal hernia repair. Am Surg 74:695–700

    PubMed  Google Scholar 

  45. Ducic I, West J, Maxted W (2008) Management of chronic postoperative groin pain. Ann Plast Surg 60:294–298. doi:10.1097/SAP.0b013e3180de600e

    Article  CAS  PubMed  Google Scholar 

  46. Giger U, Wente MN, Buchler MW, Krahenbuhl S, Lerut J, Krahenbuhl L (2009) Endoscopic retroperitoneal neurectomy for chronic pain after groin surgery. Br J Surg 96:1076–1081. doi:10.1002/bjs.6623

    Article  CAS  PubMed  Google Scholar 

  47. Vuilleumier H, Hubner M, Demartines N (2009) Neuropathy after herniorrhaphy: indication for surgical treatment and outcome. World J Surg 33:841–845. doi:10.1007/s00268-008-9869-1

    Article  PubMed  Google Scholar 

  48. Aasvang EK, Kehlet H (2009) The effect of mesh removal and selective neurectomy on persistent postherniotomy pain. Ann Surg 249:327–334

    Article  PubMed  Google Scholar 

  49. Zacest AC, Magill ST, Anderson VC, Burchiel KJ (2010) Long-term outcome following ilioinguinal neurectomy for chronic pain. J Neurosurg 112:784–789. doi:10.3171/2009.8.JNS09533

    Article  PubMed  Google Scholar 

  50. Loos MJ, Scheltinga MR, Roumen RM (2010) Tailored neurectomy for treatment of postherniorrhaphy inguinal neuralgia. Surgery 147:275–281. doi:10.1016/j.surg.2009.08.008

    Article  PubMed  Google Scholar 

  51. Amid PK, Chen DC (2011) Surgical treatment of chronic groin and testicular pain after laparoscopic and open preperitoneal inguinal hernia repair. J Am Coll Surg 213:531–536. doi:10.1016/j.jamcollsurg.2011.06.424

    Article  PubMed  Google Scholar 

  52. Koopmann MC, Yamane BH, Starling JR (2011) Long-term follow-up after meshectomy with acellular human dermis repair for postherniorrhaphy inguinodynia. Arch Surg 146:427–431. doi:10.1001/archsurg.2011.49

    Article  PubMed  Google Scholar 

  53. Bischoff JM, Enghuus C, Werner MU, Kehlet H (2013) Long-term follow-up after mesh removal and selective neurectomy for persistent inguinal postherniorrhaphy pain. Hernia 17:339–345. doi:10.1007/s10029-013-1073-z

    Article  CAS  PubMed  Google Scholar 

  54. Valvekens E, Nijs Y, Miserez M (2013) Long-term outcome of surgical treatment of chronic postoperative groin pain: a word of caution. Hernia. doi:10.1007/s10029-013-1125-4

    PubMed  Google Scholar 

  55. Chen DC, Hiatt JR, Amid PK (2013) Operative management of refractory neuropathic inguinodynia by a laparoscopic retroperitoneal approach. JAMA Surg 148:962–967. doi:10.1001/jamasurg.2013.3189

    Article  PubMed  Google Scholar 

  56. Dworkin RH, Turk DC, Wyrwich KW, Beaton D, Cleeland CS, Farrar JT, Haythornthwaite JA, Jensen MP, Kerns RD, Ader DN, Brandenburg N, Burke LB, Cella D, Chandler J, Cowan P, Dimitrova R, Dionne R, Hertz S, Jadad AR, Katz NP, Kehlet H, Kramer LD, Manning DC, McCormick C, McDermott MP, McQuay HJ, Patel S, Porter L, Quessy S, Rappaport BA, Rauschkolb C, Revicki DA, Rothman M, Schmader KE, Stacey BR, Stauffer JW, von Stein T, White RE, Witter J, Zavisic S (2008) Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendations. J Pain 9:105–121

    Article  PubMed  Google Scholar 

  57. Dworkin RH, McDermott MP, Raja SN (2010) Preventing chronic postsurgical pain: how much of a difference makes a difference? Anesthesiology 112:516–518

    Article  PubMed  Google Scholar 

  58. McCarthy M Jr, Jonasson O, Chang CH, Pickard AS, Giobbie-Hurder A, Gibbs J, Edelman P, Fitzgibbons R, Neumayer L (2005) Assessment of patient functional status after surgery. J Am Coll Surg 201:171–178

    Article  PubMed  Google Scholar 

  59. Fitzgibbons RJ, Jr., Giobbie-Hurder A, Gibbs JO, Dunlop DD, Reda DJ, McCarthy M, Jr., Neumayer LA, Barkun JS, Hoehn JL, Murphy JT, Sarosi GA, Jr., Syme WC, Thompson JS, Wang J, Jonasson O (2006) Watchful waiting vs repair of inguinal hernia in minimally symptomatic men: a randomized clinical trial. JAMA 295:285–292. 295, doi: 10.1001/jama.295.3.285

  60. Franneby U, Gunnarsson U, Andersson M, Heuman R, Nordin P, Nyren O, Sandblom G (2008) Validation of an inguinal pain questionnaire for assessment of chronic pain after groin hernia repair. Br J Surg 95:488–493. doi:10.1002/bjs.6014

    Article  CAS  PubMed  Google Scholar 

  61. Schott GD (2001) Delayed onset and resolution of pain: some observations and implications. Brain 124:1067–1076

    Article  CAS  PubMed  Google Scholar 

  62. Bennett MI, Attal N, Backonja MM, Baron R, Bouhassira D, Freynhagen R, Scholz J, Tolle TR, Wittchen HU, Jensen TS (2007) Using screening tools to identify neuropathic pain. Pain 127:199–203

    Article  PubMed  Google Scholar 

  63. Haanpaa M, Attal N, Backonja M, Baron R, Bennett M, Bouhassira D, Cruccu G, Hansson P, Haythornthwaite JA, Iannetti GD, Jensen TS, Kauppila T, Nurmikko TJ, Rice AS, Rowbotham M, Serra J, Sommer C, Smith BH, Treede RD (2011) NeuPSIG guidelines on neuropathic pain assessment. Pain 152:14–27

    Article  PubMed  Google Scholar 

  64. Vlassakov KV, Narang S, Kissin I (2011) Local anesthetic blockade of peripheral nerves for treatment of neuralgias: systematic analysis. Anesth Analg 112:1487–1493. doi:10.1213/ANE.0b013e31820d9787

    Article  CAS  PubMed  Google Scholar 

  65. Carr DB (2011) Local anesthetic blockade for neuralgias: “why is the sky blue, daddy?”. Anesth Analg 112:1283–1285. doi:10.1213/ANE.0b013e318215c58e

    Article  PubMed  Google Scholar 

  66. Bischoff JM, Koscielniak-Nielsen ZJ, Kehlet H, Werner MU (2012) Ultrasound-guided ilioinguinal/iliohypogastric nerve blocks for persistent inguinal postherniorrhaphy pain: a randomized, double-blind, placebo-controlled, crossover trial. Anesth Analg 114:1323–1329. doi:10.1213/ANE.0b013e31824d6168

    Article  PubMed  Google Scholar 

  67. Gerdesmeyer L, Wagenpfeil S, Birkenmaier C, Veihelmann A, Hauschild M, Wagner K, Muderis MA, Gollwitzer H, Diehl P, Toepfer A (2013) Percutaneous epidural lysis of adhesions in chronic lumbar radicular pain: a randomized, double-blind, placebo-controlled trial. Pain Physician 16:185–196

    PubMed  Google Scholar 

  68. Eichenberger U, Greher M, Kirchmair L, Curatolo M, Moriggl B (2006) Ultrasound-guided blocks of the ilioinguinal and iliohypogastric nerve: accuracy of a selective new technique confirmed by anatomical dissection. Br J Anaesth 97:238–243. doi:10.1093/bja/ael103

    Article  CAS  PubMed  Google Scholar 

  69. Peng PW, Tumber PS (2008) Ultrasound-guided interventional procedures for patients with chronic pelvic pain—a description of techniques and review of literature. Pain Physician 11:215–224

    PubMed  Google Scholar 

  70. Karmakar MK, Li JW, Kwok WH, Soh E, Hadzic A (2013) Sonoanatomy relevant for lumbar plexus block in volunteers correlated with cross-sectional anatomic and magnetic resonance images. Reg Anesth Pain Med 38:391–397. doi:10.1097/AAP.0b013e31829e52cc

    Article  PubMed  Google Scholar 

  71. Schmutz M, Schumacher PM, Luyet C, Curatolo M, Eichenberger U (2013) Ilioinguinal and iliohypogastric nerves cannot be selectively blocked by using ultrasound guidance: a volunteer study. Br J Anaesth 111:264–270. doi:10.1093/bja/aet028

    Article  CAS  PubMed  Google Scholar 

  72. Thomassen I, van Suijlekom JA, van de Gaag A, Ponten JE, Nienhuijs SW (2013) Ultrasound-guided ilioinguinal/iliohypogastric nerve blocks for chronic pain after inguinal hernia repair. Hernia 17:329–332. doi:10.1007/s10029-012-0998-y

    Article  CAS  PubMed  Google Scholar 

  73. Loos MJ, Verhagen T, Scheltinga MR, Roumen RM (2010) A randomised controlled trial of injection therapy versus neurectomy for post-herniorrhaphy inguinal neuralgia: rationale and study design. Hernia 14:593–597. doi:10.1007/s10029-010-0697-5

    Article  CAS  PubMed  Google Scholar 

  74. Stokvis A, van der Avoort DJ, van Neck JW, Hovius SE, Coert JH (2010) Surgical management of neuroma pain: a prospective follow-up study. Pain 151:862–869. doi:10.1016/j.pain.2010.09.032

    Article  PubMed  Google Scholar 

  75. Sen H, Sizlan A, Yanarates O, Senol MG, Inangil G, Sucullu I, Ozkan S, Dagli G (2009) The effects of gabapentin on acute and chronic pain after inguinal herniorrhaphy. Eur J Anaesthesiol 26:772–776

    Article  CAS  PubMed  Google Scholar 

  76. Bischoff JM, Petersen M, Uceyler N, Sommer C, Kehlet H, Werner MU (2013) Lidocaine patch (5 %) in treatment of persistent inguinal postherniorrhaphy pain: a randomized, double-blind, placebo-controlled, crossover trial. Anesthesiology 119:1444–1452. doi:10.1097/ALN.0b013e3182a2a243

    Article  CAS  PubMed  Google Scholar 

  77. Kerstman E, Ahn S, Battu S, Tariq S, Grabois M (2013) Neuropathic pain. Handb Clin Neurol 110:175–187. doi:10.1016/B978-0-444-52901-5.00015-0

    Article  PubMed  Google Scholar 

  78. Chua NH, Vissers KC, Sluijter ME (2011) Pulsed radiofrequency treatment in interventional pain management: mechanisms and potential indications—a review. Acta Neurochir (Wien) 153:763–771. doi:10.1007/s00701-010-0881-5

    Article  Google Scholar 

  79. Werner MU, Bischoff JM, Rathmell JP, Kehlet H (2012) Pulsed radiofrequency in the treatment of persistent pain after inguinal herniotomy: a systematic review. Reg Anesthesiol Pain Med. doi:10.1097/AAP.0b013e31824bea4e

    Google Scholar 

  80. Kastler A, Aubry S, Piccand V, Hadjidekov G, Tiberghien F, Kastler B (2012) Radiofrequency neurolysis versus local nerve infiltration in 42 patients with refractory chronic inguinal neuralgia. Pain Physician 15:237–244

    PubMed  Google Scholar 

  81. Kastler A, Aubry S, Barbier-Brion B, Jehl J, Kastler B (2012) Radiofrequency neurolysis in the management of inguinal neuralgia: preliminary study. Radiology 262:701–707. doi:10.1148/radiol.11110727

    Article  PubMed  Google Scholar 

  82. Possover M (2013) Use of the LION procedure on the sensitive branches of the lumbar plexus for the treatment of intractable postherniorrhaphy neuropathic inguinodynia. Hernia 17:333–337. doi:10.1007/s10029-011-0894-x

    Article  CAS  PubMed  Google Scholar 

  83. Altman DG, Bland JM (1995) Absence of evidence is not evidence of absence. BMJ 311:485

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  84. Stokvis A, Coert JH, van Neck JW (2010) Insufficient pain relief after surgical neuroma treatment: prognostic factors and central sensitisation. J Plast Reconstr Aesthet Surg 63:1538–1543. doi:10.1016/j.bjps.2009.05.036

    Article  PubMed  Google Scholar 

  85. Rajput K, Reddy S, Shankar H (2012) Painful neuromas. Clin J Pain 28:639–645. doi:10.1097/AJP.0b013e31823d30a2

    Article  PubMed  Google Scholar 

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Acknowledgments

The author is indebted to Joakim M. Bischoff M.D. for valuable help and discussions of the manuscript.

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Werner, M.U. Management of persistent postsurgical inguinal pain. Langenbecks Arch Surg 399, 559–569 (2014). https://doi.org/10.1007/s00423-014-1211-9

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