Abstract
Purpose
Several European countries are undertaking quality control projects in colorectal cancer. These efforts have led to improvements in survival, but a comparison between different projects reveals questionable results. The aim of this study is the presentation of results from hospitals in three different European countries participating in the International Quality Assurance in Colorectal Cancer (IQACC) project.
Methods
For this publication, patients with cancer of the colon or rectum treated in 2009 and 2010 and recorded in the IQACC (Germany, Poland and Italy) were analysed. The comparison included number of patients, age, preoperative diagnostics (CT of the abdomen and thorax, MRI, colonoscopy, ultrasound, tumour markers), surgical approach, metastasis, height of rectal cancer and histopathological examination of a specimen (T stage, N stage and MERCURY classification for rectum resection). For short-term outcomes, general complications, wound dehiscence, tumour-free status at discharge, anastomotic leakage and in-hospital mortality were analysed.
Results
A total of 12,691 patients (6,756 with colon cancer, 5,935 with rectal cancer) were included in the analysis. Preoperative diagnostics differed significantly between countries. For pT and pN stages, several quality differences could be demonstrated, including missing stages (colon cancer: pT 5.7–12.5 %, pN 2.5–11.0 %; rectal cancer: pT 1.1–5.6 %, pN 1.1–15.5 %). The most relevant differences for short-term outcomes in colon cancer were found in general complications (4.2–22.8 %) and tumour-free status at discharge (74.5–91.7 %). In-hospital deaths ranged between 2.5 and 4.3 % and did not show significant differences. For rectal cancer, the country with the highest percentage of tumours localised less than 4 cm from the anal verge (16.0 %) showed the lowest frequency of amputation (8.5 %). Outcome differences were found for general complications (3.2–18.8 %), anastomotic leakage (0–4.3 %) and tumour-free status at discharge (72.9–87.6 %). In-hospital deaths ranged between 1.1 and 3.2 %.
Conclusion
This study demonstrates the feasibility of an international quality assurance project in colorectal cancer. This concept ensures data analysis based on a comparable data input. Differences in preoperative diagnostics, completeness of histopathological evaluation and short-term outcomes for Germany, Poland and Italy might result from disparities in socioeconomic factors and implementation of existing guidelines. Further activities are necessary to warrant the use of common standards in outcome control.
Similar content being viewed by others
References
Sant M, Allemani C, Santaquilani M, Knijn A, Marchesi F, Capocaccia R, EUROCARE Working Group (2009) EUROCARE–4. Survival of cancer patients diagnosed in 1995–1999. Results and commentary. Eur J Cancer 45:931–991
Brenner H, Bouvier AM, Foschi R, Hackl M, Larsen IK, Lemmens V, Mangone L, Francisci S, EUROCARE Working Group (2012) Progress in colorectal cancer survival in Europe from the late 1980s to the early 21st century: the EUROCARE Study. Int J Cancer 131:1649–1658
Mroczkowski P, Hac S, Lippert H, Kube R (2011) Quality assurance in colorectal cancer in Europe AD 2011. Zentralbl Chir. doi:10.1055/s-0031-1283795
Van Gijn W, van den Broek CB, Mroczkowski P, Dziki A, Romano G, Pavalkis D, Wouters MW, Møller B, Wibe A, Påhlman L, Harling H, Smith JJ, Penninckx F, Ortiz H, Valentini V, van de Velde CJ (2012) The EURECCA project: data items scored by European colorectal cancer audit registries. Eur J Surg Oncol 38:467–471
Van-Gijn W, Velde CJ, members of the EURECCA consortium (2010) Improving quality of cancer care through surgical audit. Eur J Surg Oncol 36(Suppl 1):S23–S26
Mroczkowski P, Ortiz H, Penninckx F, Påhlman L (2012) European quality assurance programme in rectal cancer—are we ready to launch? Colorectal Dis 14:960–966
Mroczkowski P, Kube R, Schmidt U, Gastinger I, Lippert H (2010) Quality assessment of colorectal cancer care—an international online model. Colorectal Dis 13:890–895
Nagtegaal ID, Velde CJ, Worp E, Kapiteijn E, Quirke P, van Krieken JH, Cooperative Clinical Investigators of the Dutch Colorectal Cancer Group (2002) Macroscopic evaluation of rectal cancer resection specimen: clinical significance of the pathologistin quality control. J Clin Oncol 20:1729–1734
6 R Development Core Team (2010) R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna
Dighe S, Swift I, Brown G (2008) CT staging of colon cancer. Clin Radiol 63:1372–1379
Huh JW, Jeong YY, Kim HR, Kim YJ (2012) Prognostic value of preoperative radiological staging assessed by computed tomography in patients with nonmetastatic colon cancer. Ann Oncol 23:1198–1206
Kosmider S, Stella DL, Field K, Moore M, Ananda S, Oakman C, Singh M, Gibbs P (2009) Preoperative investigations for metastatic staging of colon and rectal cancer across multiple centres—what is current practice? Colorectal Dis 11:592–600
Van de Velde CJ, Aristei C, Boelens PG, Beets-Tan RG, Blomqvist L, Borras JM, van den Broek CB, Brown G, Coebergh JW, Cutsem EV, Espin E, Gore-Booth J, Glimelius B, Haustermans K, Henning G, Iversen LH, Han van Krieken J, Marijnen CA, Mroczkowski P, Nagtegaal I, Naredi P, Ortiz H, Påhlman L, Quirke P, Rödel C, Roth A, Rutten HJ, Schmoll HJ, Smith J, Tanis PJ, Taylor C, Wibe A, Gambacorta MA, Meldolesi E, Wiggers T, Cervantes A, Valentini V, European Registration of Cancer Care (2013) EURECCA colorectal: multidisciplinary mission statement on better care for patients with colon and rectal cancer in Europe. Eur J Cancer 49:2784–2790. doi:10.1016/j.ejca.2013.04.032
Akasu T, Iinuma G, Takawa M, Yamamoto S, Muramatsu Y, Moriyama N (2009) Accuracy of high-resolution magnetic resonance imaging in preoperative staging of rectal cancer. Ann Surg Oncol 16:2787–2794
Maizlin ZV, Brown JA, So G, Brown C, Phang TP, Walker ML, Kirby JM, Vora P, Tiwari P (2010) Can CT replace MRI in preoperative assessment of the circumferential resection margin in rectal cancer? Dis Colon Rectum 53:308–314
OECD Health Data 2012 (2012) Frequently requested data. http://www.oecd.org/health/healthpoliciesanddata/oecdhealthdata2012-frequentlyrequesteddata.htm. Accessed 3 January 2013
Schmoll HJ, Van Cutsem E, Stein A, Valentini V, Glimelius B, Haustermans K, Nordlinger B, van de Velde CJ, Balmana J, Regula J, Nagtegaal ID, Beets-Tan RG, Arnold D, Ciardiello F, Hoff P, Kerr D, Köhne CH, Labianca R, Price T, Scheithauer W, Sobrero A, Tabernero J, Aderka D, Barroso S, Bodoky G, Douillard JY, El Ghazaly H, Gallardo J, Garin A, Glynne-Jones R, Jordan K, Meshcheryakov A, Papamichail D, Pfeiffer P, Souglakos I, Turhal S, Cervantes A (2012) ESMO consensus guidelines for management of patients with colon and rectal cancer. A personalized approach to clinical decision making. Ann Oncol 23:2479–2516
German S3-Guideline (2013) Colorectal cancer. http://www.awmf.org/uploads/tx_szleitlinien/021_007OLl_S3_KRK_14062013.pdf. Accessed 6 December 2013
Pappalardo G, Nunziale A, Coiro S, Spoletini D, De Lucia F, Frattaroli FM (2010) Results of a national questionnaire on “treatment of the subperitoneal rectal cancer”. Comparision among the international guidelines and metaanalysis. Ann Ital Chir 81:275–281
AIOM Guideline (2003) Colorectal cancer. http://www.aiom.it/area+pubblica/area+medica/prodotti+scientifici/linee+guida/Tumori+del+colon-retto/1,1979,0. Accessed 18 January 2013
Rekomendacje Konsultanta Krajowego W Chirurgii Onkologicznej stan na 1.3.2013 (2013) Rak jelita grubego. http://chirurgiaonkologiczna.org.pl/rekomendacje/rekomendacje-merytoryczne/rak-jelita-grubego. Accessed 8 December 2013
Yeung JM, Ferris NJ, Lynch AC, Heriot AG (2009) Preoperative staging of rectal cancer. Future Oncol 5:1295–1306
Wibe A, Møller B, Norstein J, Carlsen E, Wiig JN, Heald RJ, Langmark F, Myrvold HE, Søreide O, Norwegian Rectal Cancer Group (2002) A national strategic change in treatment policy for rectal cancer—implementation of total mesorectal excision as routine treatment in Norway. A national audit. Dis Colon Rectum 45:857–866
Marr R, Birbeck K, Garvican J, Macklin CP, Tiffin NJ, Parsons WJ, Dixon MF, Mapstone NP, Sebag-Montefiore D, Scott N, Johnston D, Sagar P, Finan P, Quirke P (2005) The modern abdominoperineal excision: the next challenge after total mesorectal excision. Ann Surg 242:74–82
West NP, Anderin C, Smith KJ, Holm T, Quirke P, European Extralevator Abdominoperineal Excision Study Group (2010) Multicentre experience with extralevator abdominoperineal excision for low rectal cancer. Br J Surg 97:588–599
Stelzner S, Koehler C, Stelzer J, Sims A, Witzigmann H (2011) Extended abdominoperineal excision vs. standard abdominoperineal excision in rectal cancer—a systematic overview. Int J Colorectal Dis 26:1227–1240
Van de Velde CJ, Boelens PG, Borras JM, Coebergh JW, Cervantes A, Blomqvist L, Beets-Tan RG, van den Broek CB, Brown G, Van Cutsem E, Espin E, Haustermans K, Glimelius B, Iversen LH, van Krieken JH, Marijnen CA, Henning G, Gore-Booth J, Meldolesi E, Mroczkowski P, Nagtegaal I, Naredi P, Ortiz H, Påhlman L, Quirke P, Rödel C, Roth A, Rutten H, Schmoll HJ, Smith JJ, Tanis PJ, Taylor C, Wibe A, Wiggers T, Gambacorta MA, Aristei C, Valentini V (2014) EURECCA colorectal: multidisciplinary management: European consensus conference colon & rectum. Eur J Cancer 50:1.e1–1.e34. doi:10.1016/j.ejca.2013.06.048
Acknowledgments
The multilingual internet platform was supported by the following grants from the German Ministry for Education and Research (BMBF): NOE 11/056, MOE 10/R53 and MOE 07/R65.
Disclosures
Drs. Olof Jannasch, Andrej Udelnow, Giovanni Romano, Adam Dziki, Dainius Pavalkis, Hans Lippert and Pawel Mroczkowski have no conflicts of interest or financial ties to disclose.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Jannasch, O., Udelnow, A., Romano, G. et al. International quality assurance project in colorectal cancer—unifying diagnostic and histopathological evaluation. Langenbecks Arch Surg 399, 473–479 (2014). https://doi.org/10.1007/s00423-014-1176-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00423-014-1176-8