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Probiotics in patients with severe acute pancreatitis: a meta-analysis

  • New Surgical Horizons
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Abstract

Background

This study focuses on probiotics in patients with severe acute pancreatitis. It assesses whether enteral feeding with probiotics use reduces infected necrosis and death in severe acute pancreatitis.

Materials and methods

We searched the Cochrane Library, Medline, Embase, and Chinese Biomedicine Database. Quality assessment and data extraction were done by two reviewers independently. The statistical analysis was performed by RevMan4.2.10 software. The result was expressed with odds ratio (OR) for the categorical variable.

Results

Four studies were included. The result showed that using probiotics could not reduce the risk of infection pancreatic necrosis (OR = 0.56, 95% CI [0.13, 2.35]). There is no significant difference between the two groups in mortality (OR = 0.83, 95% CI [0.14, 4.83]), the mean duration of hospital (WMD = −1.20, 95% CI [−13.13, 10.92]) and the required operation (OR = 0.59, 95% CI [0.11, 3.07]).

Conclusion

The present study showed the enteral feeding with probiotic could not reduce the infected necrosis and mortality. Future large-scale, high-quality, placebo-controlled, double-blind trials are needed.

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Acknowledgment

Thanks a lot to the co-authors and all authors, who have contributed significantly. All authors are in agreement with the content of the manuscript. The copyright will be sent to your Journal.

I appreciate the China Evidence-based Medicine Center.

Conflict of interest:

There is no financial support or relationships that may pose conflict of interest in this study paper.

Funding sources:

None.

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Authors and Affiliations

  1. The Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China

    Shaoliang Sun, Kehu Yang, Jinhui Tian, Bin Ma & Lei Jiang

  2. The First Clinical College, Lanzhou University, Lanzhou, 730000, China

    Shaoliang Sun & Kehu Yang

  3. The Second Clinical College, Lanzhou University, Lanzhou, 730000, China

    Xiaodong He

Authors
  1. Shaoliang Sun
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  2. Kehu Yang
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  3. Xiaodong He
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  4. Jinhui Tian
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Corresponding author

Correspondence to Kehu Yang.

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Sun, S., Yang, K., He, X. et al. Probiotics in patients with severe acute pancreatitis: a meta-analysis. Langenbecks Arch Surg 394, 171–177 (2009). https://doi.org/10.1007/s00423-008-0379-2

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  • DOI: https://doi.org/10.1007/s00423-008-0379-2

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