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Solitary fibrous tumour of the liver with IGF-II-related hypoglycaemia. A case report

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Abstract

Introduction

We report a rare case of solitary fibrous tumour (SFT) of the liver associated with non-islet cell tumour hypoglycaemia (NICTH), which caused a hypoglycaemic coma due to over-production of big-insulin-like growth factor-II.

Discussion

Although generally benign, SFTs are better characterised, lately due to Western blot, but less than 40 cases have been reported where the liver is the target organ. In only two benign cases has hypoglycaemia been a feature.

Conclusion

We report for the first time a demonstrable relationship between benign liver SFT and NICTH.

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Acknowledgements

The Authors dedicate this article to the memory of Roberto Pidoto, who instigated this study, but unfortunately died during its preparation.

Conflict of Interests

There was no grant support and no conflict of interest exists.

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Authors and Affiliations

  1. Service Chirurgie Viscérale, Endocrinienne et Thoracique, Centre Hospitalier Régional Orléans, 14, Avenue de l’Hôpital, 45 067, Orléans, France

    R. R. Pidoto & O. Saint Marc

  2. Service Endocrinologie, Centre Hospitalier Régional Orléans, 14, Avenue de l’Hôpital, 45 067, Orléans, France

    G. Barrande & A. Villeneuve

  3. Department of Human Pathology, University Hospital of Messina, Via Consolare Valeria, 1, 98100, Messina, Italy

    F. Famà & M. G. Berry

  4. APHP, Hôpital Armand Trousseau, Explorations Fonctionnelles Endocriniennes, UPMC Paris VI, Inserm U.515, 26 Avenue Netter, 75571, Paris, France

    Yves Le Bouc

  5. Complesso Residenziale MITO, Residenza del Parco A/8, 98151, Camaro Superiore, Messina, Italy

    F. Famà

Authors
  1. F. Famà
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  2. Yves Le Bouc
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  3. G. Barrande
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  4. A. Villeneuve
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  5. M. G. Berry
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  6. R. R. Pidoto
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  7. O. Saint Marc
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Correspondence to F. Famà.

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Famà, F., Bouc, Y.L., Barrande, G. et al. Solitary fibrous tumour of the liver with IGF-II-related hypoglycaemia. A case report. Langenbecks Arch Surg 393, 611–616 (2008). https://doi.org/10.1007/s00423-008-0329-z

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  • DOI: https://doi.org/10.1007/s00423-008-0329-z

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