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Solitary fibrous tumour of the liver: case report and review of the literature

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Abstract

Background

Solitary fibrous tumours (SFTs) of the liver are very rare entities. Although firstly described to be tumours of pleural origin, SFTs have been reported in various organs such as the meninges, orbit, upper respiratory tract, thyroid, peritoneum, retroperitoneum and soft tissues. Histologically, this tumour often shows alternating cellular and relatively acellular areas. The cellular areas show a wide variety of patterns, making it difficult for it to be differentiated from other mesenchymal tumours. Its immunohistochemical positivity for CD34 and vimentin is believed to be unique. Histiogenesis of SFTs, however, is not yet fully understood. They are known to be usually benign, with only few reports indicating their ability to metastasize.

Patients and methods

We review the literature on SFTs of the liver and report on the case of a 63-year-old female patient with a large SFT of the right liver.

Conclusions

Surgical resection seems to be the treatment of choice. Local recurrence is scarce. Due to the very limited number of cases, data regarding the long-term survival of patients are lacking.

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References

  1. Klemperer P, Rabin C (1931) Primary neoplasms of the pleura: a report of 5 cases. Arch Pathol 11:385–412

    Google Scholar 

  2. Sawauchi S, Arakawa H, Taya K, Terao T, Nakazaki H, Numoto RT, Yamaguchi Y, Hashimoto T, Yamaguchi Y, Abe T (2003) Solitary fibrous tumor of the fourth ventricle: case report. No Shinkei Geka 31:551–555

    PubMed  Google Scholar 

  3. Westra WH, Gerald WL, Rosai J (1994) Solitary fibrous tumor. Consistent CD34 immunoreactivity and occurrence in the orbit. Am J Surg Pathol 18:992–998

    CAS  PubMed  Google Scholar 

  4. Dorfman DM, To K, Dickersin GR, Rosenberg AE, Pilch BZ (1994) Solitary fibrous tumor of the orbit. Am J Surg Pathol 18:281–287

    CAS  PubMed  Google Scholar 

  5. Alobid I, Alos L, Blanch JL, Benitez P, Bernal-Sprekelsen M, Mullol J (2003) Solitary fibrous tumour of the nasal cavity and paranasal sinuses. Acta Otolaryngol 123:71–74

    Article  PubMed  Google Scholar 

  6. Cameselle-Teijeiro J, Varela-Duran J, Fonseca E, Villanueva JP, Sobrinho-Simoes M (1994) Solitary fibrous tumor of the thyroid. Am J Clin Pathol 101:535–538

    PubMed  Google Scholar 

  7. Fukunaga M, Naganuma H, Nikaido T, Harada T, Ushigome S (1997) Extrapleural solitary fibrous tumor: a report of seven cases. Mod Pathol 10:443–450

    CAS  PubMed  Google Scholar 

  8. Kume M, Komori K, Inoguchi H, Shoji T, Furuyama T, Sakamoto A, Sugimachi K (2002) Solitary fibrous tumor in the retroperitoneal space: report of a case. Surg Today 32:1099–1101

    Article  PubMed  Google Scholar 

  9. Dalton WT, Zolliker AS, McCaughey WT, Jacques J, Kannerstein M (1979) Localized primary tumors of the pleura: an analysis of 40 cases. Cancer 44:1465–1475

    CAS  PubMed  Google Scholar 

  10. El Naggar AK, Ro JY, Ayala AG, Ward R, Ordonez NG (1989) Localized fibrous tumor of the serosal cavities. Immunohistochemical, electron-microscopic, and flow-cytometric DNA study. Am J Clin Pathol 92:561–565

    CAS  PubMed  Google Scholar 

  11. Briselli M, Mark EJ, Dickersin GR (1981) Solitary fibrous tumors of the pleura: eight new cases and review of 360 cases in the literature. Cancer 47:2678–2689

    CAS  PubMed  Google Scholar 

  12. Krismann M, Adams H, Jaworska M, Muller KM, Johnen G (2000) Benign solitary fibrous tumour of the thigh: morphological, chromosomal and differential diagnostic aspects. Langenbecks Arch Surg 385:521–525

    Article  CAS  PubMed  Google Scholar 

  13. Kottke-Marchant K, Hart WR, Broughan T (1989) Localized fibrous tumor (localized fibrous mesothelioma) of the liver. Cancer 64:1096–1102

    CAS  PubMed  Google Scholar 

  14. Vallat-Decouvelaere AV, Dry SM, Fletcher CD (1998) Atypical and malignant solitary fibrous tumors in extrathoracic locations: evidence of their comparability to intra-thoracic tumors. Am J Surg Pathol 22:1501–1511

    Article  CAS  PubMed  Google Scholar 

  15. Moran CA, Ishak KG, Goodman ZD (1998) Solitary fibrous tumor of the liver: a clinicopathologic and immunohistochemical study of nine cases. Ann Diagn Pathol 2:19–24

    Article  CAS  PubMed  Google Scholar 

  16. van de Rijn M, Lombard CM, Rouse RV (1994) Expression of CD34 by solitary fibrous tumors of the pleura, mediastinum, and lung. Am J Surg Pathol 18:814–820

    PubMed  Google Scholar 

  17. Sawada N, Ishiwata T, Naito Z, Maeda S, Sugisaki Y, Asano G (2002) Immunohistochemical localization of endothelial cell markers in solitary fibrous tumor. Pathol Int 52:769–776

    Article  PubMed  Google Scholar 

  18. Nevius DB, Friedman NB (1959) Mesotheliomas and extraovarian thecomas with hypoglycemic and nephrotic syndromes. Cancer 1263–1269

  19. Edmondson HA (1958) Tumors of the liver and intrahepatic bile ducts. Atlas of tumor pathology, Fascicle 25. Armed Forces Institute of Pathology, Washington, DC, pp 113–137, 216

  20. Ishak KG (1976) Mesenchymal tumors of the liver. In: Okuda K, Peters RL (eds) Hepatocellular carcinoma. Wiley, New York, pp 247–307

  21. Kim H, Damjanov I (1983) Localized fibrous mesothelioma of the liver. Report of a giant tumor studied by light and electron microscopy. Cancer 52:1662–1665

    CAS  PubMed  Google Scholar 

  22. Kasano Y, Tanimura H, Tabuse K, Nagai Y, Mori K, Minami K (1991) Giant fibrous mesothelioma of the liver. Am J Gastroenterol 86:379–380

    Google Scholar 

  23. Barnoud R, Arvieux C, Pasquier D, Pasquier B, Letoublon C (1996) Solitary fibrous tumour of the liver with CD34 expression. Histopathology 28:551–554

    Article  CAS  PubMed  Google Scholar 

  24. Levine TS, Rose DS (1997) Solitary fibrous tumour of the liver. Histopathology 30:396–397

    CAS  PubMed  Google Scholar 

  25. Guglielmi A, Frameglia M, Iuzzolino P, Martignoni G, De Manzoni G, Laterza E, Veraldi GF, Girlanda R (1998) Solitary fibrous tumor of the liver with CD34 positivity and hypoglycemia. J Hepatobiliary Pancreat Surg 5:212–216

    Article  CAS  PubMed  Google Scholar 

  26. Fuksbrumer MS, Klimstra D, Panicek DM (2000) Solitary fibrous tumor of the liver: imaging findings. Am J Roentgenol 175:1683–1687

    CAS  Google Scholar 

  27. Yilmaz S, Kirimlioglu V, Ertas E, Hilmioglu F, Yildirim B, Katz D, Mizrak B (2000) Giant solitary fibrous tumor of the liver with metastasis to the skeletal system successfully treated with trisegmentectomy. Dig Dis Sci 45:168–174

    Article  CAS  PubMed  Google Scholar 

  28. Lin YT, Lo GH, Lai KH, Tsai CC, Pan HB, Tseng HH, Lo YS (2001) Solitary fibrous tumor of the liver. Zhonghua Yi Xue Za Zhi (Taipei) 64:305–309

    Google Scholar 

  29. Saint-Marc O, Pozzo A, Causse X, Heitzmann A, Debillon G (2002) Solitary fibrous liver tumor: clinical, radiological and pathological characteristics. Gastroenterol Clin Biol 26:171–173

    PubMed  Google Scholar 

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Correspondence to Hannes Neeff.

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Neeff, H., Obermaier, R., Technau-Ihling, K. et al. Solitary fibrous tumour of the liver: case report and review of the literature. Langenbecks Arch Surg 389, 293–298 (2004). https://doi.org/10.1007/s00423-004-0488-5

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  • DOI: https://doi.org/10.1007/s00423-004-0488-5

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