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Clinicopathological characteristics of gastric carcinoma in young patients

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Abstract

Background and aims

Gastric carcinoma is a common disease that usually affects older patients, rarely younger patients. Although the relationship between prognosis and the age of patients with gastric carcinoma is controversial, most investigators have suggested that young patients have a poorer prognosis. This study examined the clinicopathological features of young patients with gastric carcinoma.

Patients and methods

We retrospectively reviewed the hospital records of 1,833 patients with gastric carcinoma to compare the clinicopathological findings in young (aged <36 years) and older (aged ≥ 36 years) patients during the period 1988 to 1998 in a tertiary referral center in Gwangju City. Overall survival was the main outcome measure.

Results

Of the 1,833 patients, 137 (7.5%) were in the young age group. There were no significant differences in depth of invasion, lymph node invasion, hepatic metastasis, peritoneal dissemination, tumor stage or rate of curative resection. A significantly higher percentage of young patients had poorly differentiated histology (P=0.0001). The young patients with curatively resected gastric carcinoma had a better survival rate than young patients with non-resected gastric carcinoma (P<0.001). The 5-year survival rates of young and older patients did not differ statistically (39.6% vs 42.4%; P=0.254).

Conclusion

Young patients with gastric carcinoma do not have a worse prognosis than older patients. The important prognostic factor was whether the patients underwent curative resection.

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References

  1. Sanchez-Bueno F, Garcia-Marcilla JA, Perez-Flores D, Perez-Abad JM, Vicente R, Aranda F, Ramirez P, Parrilla P (1988) Prognostic factors in a series of 297 patients with gastric adenocarcinoma undergoing surgical resection. Br J Surg 85:255–260

    Article  Google Scholar 

  2. Mitsudomi T, Matsusaka T, Wakasugi K, Takenaka M, Kume K, Fujinaga Y, Teraoka H, Iwashita A (1989) A clinicopathological study of gastric cancer with special reference to age of the patients: an analysis of 1,630 cases. World J Surg 13:225–231

    CAS  PubMed  Google Scholar 

  3. Tso PL, Bringaze III WL, Dauterive AH, Correa P, Cohn I (1987) Gastric carcinoma in the young. Cancer 59:1362–1365

    CAS  PubMed  Google Scholar 

  4. Wang JY, Hsieh JS, Huang CJ, Huang YS, Huang TJ (1996) Clinicopathologic study of advanced gastric cancer without serosal invasion in young and old patients. J Surg Oncol 63:36–40

    Article  CAS  PubMed  Google Scholar 

  5. Holburt E, Freedman SI (1987) Gastric carcinoma in patients younger than age 36 years. Cancer 60:1395–1399

    CAS  PubMed  Google Scholar 

  6. Matley PJ, Dent DM, Madden MV, Price SK (1988) Gastric carcinoma in young adults. Ann Surg 208:593–596

    CAS  PubMed  Google Scholar 

  7. Mori M, Sugimach K, Ohiwa T, Okamura T, Tamura S, Inokuchi K (1985) Early gastric carcinoma in Japanese patients under 30 years of age. Br J Surg 72:289–291

    CAS  PubMed  Google Scholar 

  8. Grabiec J, Owen DA (1985) Carcinoma of the stomach in young persons. Cancer 56:388–396

    CAS  PubMed  Google Scholar 

  9. Suk D (1990) Stomach carcinoma in the young adult; analysis of 111 cases, and review from literature. J Korean Cancer Assoc 22:202–207

    Google Scholar 

  10. Tokunaga A, Nishi K, Matsukura N, Tanaka N, Onda M, Shirota A, Asano G, Hayashi K (1986) Estrogen and progesterone receptors in gastric cancer. Cancer 57:1376–1379

    CAS  PubMed  Google Scholar 

  11. Harrison JD, Jones JA, Ellis IO, Morris DL (1991) Oestrogen receptor D5 antibody is an independent negative prognostic factor in gastric cancer. Br J Surg 78:334–336

    CAS  PubMed  Google Scholar 

  12. Choi JH, Chung HC, Yoo NC, Lee HR, Lee KH, Kim JH, Roh JK, Park CS, Min JS, Lee KS, Kim BS, Lim HY (1996) Gastric cancer in young patients who underwent curative resection. Am J Clin Oncol 19:45–48

    Article  CAS  PubMed  Google Scholar 

  13. Nakamura T, Yao T, Niho Y, Tsuneyoshi M (1999) A clinicopathological study in young patients with gastric carcinoma. J Surg Oncol 71:214–219

    Article  CAS  PubMed  Google Scholar 

  14. Takahashi Y, Naonori T, Shin T, Yasuo Y, Toshihiro S, Kenji K, Shu K, Yasuo K, Hidemi Y (1999) Early gastric cancer in the young: clinicopathological study. Aust N Z J Surg 69:443–446

    Article  PubMed  Google Scholar 

  15. Eguchi T, Takahashi Y, Yamagata M, Kasahara M, Fujii M (1999) Gastric cancer in young patients. J Am Coll Surg 188:22–26

    Article  CAS  PubMed  Google Scholar 

  16. Bloss RS, Miller TA, Copeland EM III (1980) Carcinoma of the stomach in the young adult. Surg Gynecol Obstet 150:883–886

    CAS  PubMed  Google Scholar 

  17. Lo SS, Kuo HS, Wu CW, Hsieh MC, Shyr YM, Wang HC, Lui WY (1999) Poorer prognosis in young patients with gastric cancer? Hepatogastroenterology 46:2690–2693

    Google Scholar 

  18. Okamoto T, Makino M, Kawasumi H (1988) Comparative study of gastric cancer in young and aged patients. Eur Surg Res 20:149–155

    CAS  PubMed  Google Scholar 

  19. Medina-Franco H, Heslin MJ, Cortes-Gonzalez R (2000) Clinicopathological characteristics of gastric carcinoma in young and elderly patients: a comparative study. J Surg Oncol 7:515–519

    CAS  Google Scholar 

  20. Kokkola A, Sipponen P (2001) Gastric carcinoma in young adults. Hepatogastroenterology 48:1552–1555

    CAS  PubMed  Google Scholar 

  21. Jin F, Wang S, Chen J (1999) Biologic behavior and prognosis of patients with gastric cancer in young persons. Zhonghua Wai Ke Za Zhi 37:154-156

    CAS  PubMed  Google Scholar 

  22. Fujimoto S, Takahashi M, Ohkubo H, Mutou T, Kure M, Masaoka H, Kobayashi K (1994) Comparative clinicopathologic features of early gastric cancer in young and older patients. Surgery 115:516–520

    CAS  PubMed  Google Scholar 

  23. Maehara Y, Emi Y, Tomisaki S (1996) Age-related characteristics of gastric carcinoma in young and elderly patients. Cancer 77:1774–1780

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Gastroenterological Surgery, Department of Surgery, Chonnam National University Medical School, 8 Hakdong, Dongku, Gwangju, Korea

    D. Y. Kim, S. Y. Ryu, Y. J. Kim & S. K. Kim

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  1. D. Y. Kim
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  2. S. Y. Ryu
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  3. Y. J. Kim
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  4. S. K. Kim
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Correspondence to D. Y. Kim.

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Kim, D.Y., Ryu, S.Y., Kim, Y.J. et al. Clinicopathological characteristics of gastric carcinoma in young patients. Langenbecks Arch Surg 388, 245–249 (2003). https://doi.org/10.1007/s00423-003-0387-1

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  • DOI: https://doi.org/10.1007/s00423-003-0387-1

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