Giant squid-hidden canard: the 3D geometry of the Hodgkin–Huxley model

Abstract

This work is motivated by the observation of remarkably slow firing in the uncoupled Hodgkin–Huxley model, depending on parameters τ _h , τ _n that scale the rates of change of the gating variables. After reducing the model to an appropriate nondimensionalized form featuring one fast and two slow variables, we use geometric singular perturbation theory to analyze the model’s dynamics under systematic variation of the parameters τ _h , τ _n , and applied current I. As expected, we find that for fixed (τ _h , τ _n ), the model undergoes a transition from excitable, with a stable resting equilibrium state, to oscillatory, featuring classical relaxation oscillations, as I increases. Interestingly, mixed-mode oscillations (MMO’s), featuring slow action potential generation, arise for an intermediate range of I values, if τ _h or τ _n is sufficiently large. Our analysis explains in detail the geometric mechanisms underlying these results, which depend crucially on the presence of two slow variables, and allows for the quantitative estimation of transitional parameter values, in the singular limit. In particular, we show that the subthreshold oscillations in the observed MMO patterns arise through a generalized canard phenomenon. Finally, we discuss the relation of results obtained in the singular limit to the behavior observed away from, but near, this limit.