Abstract
This study investigated the relationship between walking ability and age-related muscle atrophy of the lower limbs in elderly women. The subjects comprised 20 young women and 37 elderly women who resided in nursing homes or chronic care institutions. The elderly subjects were divided into three groups according to their walking ability. The muscle thickness of the following ten lower limb muscles were measured by B-mode ultrasound: the gluteus maximus, gluteus medius, gluteus minimus, psoas major, rectus femoris, vastus lateralis, vastus intermedius, biceps femoris, gastrocnemius and soleus. Compared to the young group, muscle thicknesses of all muscles except the soleus muscle were significantly smaller in all the elderly groups. There were no significant differences between the fast- and slow-walking groups in the thickness of any muscle. In the dependent elderly group, noticeable muscle atrophy was observed in the quadriceps femoris muscle. The results of this study suggest that the elderly who are capable of locomotion, regardless of their walking speed, show a moderate degree of age-related atrophy, while those who do not walk exhibit more severe atrophy, especially in the quadriceps femoris muscle.
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Akima H, Kuno S, Suzuki Y, Gunji A, Fukunaga T (1997) Effects of 20 days of bed rest on physiological cross-sectional area of human thigh and leg muscles evaluated by magnetic resonance imaging. J Gravit Physiol 4:S15–S21
Akima H, Kano Y, Enomoto Y, Ishizu M, Okada M, Oishi Y, Katsuta S, Kuno S (2001) Muscle function in 164 men and women aged 20–84 yr. Med Sci Sports Exerc 33:220–226
Allen TH, Andersen EC, Langham WH (1960) Total body potassium and gross body composition in relationship to age. J Gerontol 15:348–357
Andersson E, Oddsson L, Grundström H, Thorstensson A (1995) The role of the psoas and iliacus muscles for stability and movement of the lumbar spine, pelvis and hip. Scand J Med Sci Sports 5:10–16
Arts IM, Pillen S, Schelhaas HJ, Overeem S, Zwarts MJ (2010) Normal values for quantitative muscle ultrasonography in adults. Muscle Nerve 41:32–41
Bemben MG, Massey BH, Bemben DA, Misner JE, Boileau RA (1991) Isometric force production as a function of age in healthy 20- to 74-yr-old men. Med Sci Sports Exerc 23:1302–1310
Berg HE, Larsson L, Tesch PA (1997) Lower limb skeletal muscle function after 6 wk of bed rest. J Appl Physiol 82:182–188
Blazevich AJ, Gill ND, Zhou S (2006) Intra- and intermuscular variation in human quadriceps femoris architecture assessed in vivo. J Anat 209:289–310
Booth FW (1982) Effect of limb immobilization on skeletal muscle. J Appl Physiol 52:1113–1118
Brooks SV, Faulkner JA (1994) Skeletal muscle weakness in old age: underlying mechanisms. Med Sci Sports Exercise 26:432–439
Buchner DM, Larson EB, Wagner EH, Koepsell TD, de Lateur BJ (1996) Evidence for a non-linear relationship between leg strength and gait speed. Age Ageing 25:386–391
Doherty TJ, Vandervoort AA, Brown WF (1993) Effects of ageing on the motor unit: a brief review. Can J Appl Physiol 18:331–358
Dupont AC, Sauerbrei EE, Fenton PV, Shragge PC, Loeb GE, Richmond FJ (2001) Real-time sonography to estimate muscle thickness: comparison with MRI and CT. J Clin Ultrasound 29:230–236
Ferrando AA, Stuart CA, Brunder DG, Hillman GR (1995) Magnetic resonance imaging quantitation of changes in muscle volume during 7 days of strict bed rest. Aviat Space Environ Med 66:976–981
Ferrucci L, Guralnik JM, Buchner D, Kasper J, Lamb SE, Simonsick EM, Corti MC, Bandeen-Roche K, Fried LP (1997) Departures from linearity in the relationship between measures of muscular strength and physical performance of the lower extremities: the Women’s Health and Aging Study. J Gerontol A Biol Sci Med Sci 52:M275–M285
Fujiwara K, Asai H, Toyama H, Kunita K, Yaguchi C, Kiyota N, Tomita H, Jacobs JV (2010) Changes in muscle thickness of gastrocnemius and soleus associated with age and sex. Aging Clin Exp Res 22:24–30
Fukunaga T, Miyatani M, Tachi M, Kouzaki M, Kawakami Y, Kanehisa H (2001) Muscle volume is a major determinant of joint torque in humans. Acta Physiol Scand 172:249–255
Hides JA, Belavý DL, Stanton W, Wilson SJ, Rittweger J, Felsenberg D, Richardson CA (2007) Magnetic resonance imaging assessment of trunk muscles during prolonged bed rest. Spine 32:1687–1692
Hikida RS, Gollnick PD, Dudley GA, Convertino VA, Buchanan P (1989) Structural and metabolic characteristics of human skeletal muscle following 30 days of simulated microgravity. Aviat Space Environ Med 60:664–670
Janssen I, Heymsfield SB, Wang Z, Ross R (2000) Skeletal muscle mass and distribution in 468 men and women aged 18–88 yr. J Appl Physiol 89:81–88
Johnson MA, Polgar J, Weightman D, Appleton D (1973) Data on the distribution of fibre types in thirty-six human muscles. An autopsy study. J Neurol Sci 18:111–129
Kellis E, Galanis N, Natsis K, Kapetanos G (2009) Validity of architectural properties of the hamstring muscles: correlation of ultrasound findings with cadaveric dissection. J Biomech 13;42(15):2549–2554
Kubo K, Kanehisa H, Azuma K, Ishizu M, Kuno SY, Okada M, Fukunaga T (2003a) Muscle architectural characteristics in women aged 20–79 years. Med Sci Sports Exerc 35:39–44
Kubo K, Kanehisa H, Azuma K, Ishizu M, Kuno SY, Okada M, Fukunaga T (2003b) Muscle architectural characteristics in young and elderly men and women. Int J Sports Med 24:125–130
Kwon IS, Oldaker S, Schrager M, Talbot LA, Fozard JL, Metter EJ (2001) Relationship between muscle strength and the time taken to complete a standardized walk-turn-walk test. J Gerontol A Biol Sci Med Sci 56A:B398–B404
Lexell J, Taylor CC, Sjostrom M (1988) What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men. J Neurol Sci 84:275–294
Macaluso A, De Vito G (2004) Muscle strength, power and adaptations to resistance training in older people. Eur J Appl Physiol 91:450–472
Maganaris CN, Baltzopoulos V, Sargeant AJ (1998) In vivo measurements of the triceps surae complex architecture in man: implications for muscle function. J Physiol 512:603–614
Miyatani M, Kanehisa H, Ito M, Kawakami Y, Fukunaga T (2004) The accuracy of volume estimates using ultrasound muscle thickness measurements in different muscle groups. Eur J Appl Physiol 91:264–272
Narici MV, Binzoni T, Hiltbrand E, Fasel J, Terrier F, Cerretelli P (1996) In vivo human gastrocnemius architecture with changing joint angle at rest and during graded isometric contraction. J Physiol 496:287–297
Ohira Y, Jiang B, Roy RR, Oganov V, Ilyina-Kakueva E, Marini JF, Edgerton VR (1992) Rat soleus muscle fiber responses to 14 days of spaceflight and hindlimb suspension. J Appl Physiol 73(Suppl 2):51S–57S
Park H, Park S, Shephard RJ, Aoyagi Y (2010) Yearlong physical activity and sarcopenia in older adults: the Nakanojo Study. Eur J Appl Physiol 25 [Epub ahead of print]
Rantanen T, Guralnik JM, Izmirlian G, Williamson JD, Simonsick EM, Ferrucci L, Fried LP (1998) Association of muscle strength with maximum walking speed in disabled older women. Am J Phys Med Rehabil 77:299–305
Reimers CD, Harder T, Saxe H (1998) Age-related muscle atrophy does not affect all muscles and can partly be compensated by physical activity: an ultrasound study. J Neurol Sci 159:60–66
Roos MR, Rice CL, Vandervoort AA (1997) Age-related changes in motor unit function. Muscle Nerve 20:679–690
Sanada K, Kearns C, Midorikawa T, Abe T (2006) Prediction and validation of total and regional skeletal muscle mass by ultrasound in Japanese adults. Eur J Appl Physiol 96:24–31
Sandler RB, Burdett R, Zaleskiewicz M, Sprowls-Repcheck C, Harwell M (1991) Muscle strength as an indicator of physical activity. Med Sci Sports Exerc 23:1375–1381
Shimada H, Suzukawa M, Tiedemann A, Kobayashi K, Yoshida H, Suzuki T (2009) Which neuromuscular or cognitive test is the optimal screening tool to predict falls in frail community-dwelling older people? Gerontology 55:532–538
Templeton GH, Sweeney HL, Timson BF, Padalino M, Dudenhoeffer GA (1988) Changes in fiber composition of soleus muscle during rat hindlimb suspension. J Appl Physiol 65:1191–1195
Thoirs K, English C (2009) Ultrasound measures of muscle thickness: intra-examiner reliability and influence of body position. Clin Physiol Funct Imaging 29:440–446
Walton JM, Roberts N, Whitehouse GH (1997) Measurement of the quadriceps femoris muscle using magnetic resonance and ultrasound imaging. Br J Sports Med 31:59–64
Young A, Stokes M, Crowe M (1985) The size and strength of the quadriceps muscles of old and young men. Clin Physiol 5:145–154
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Communicated by Alain Martin.
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Ikezoe, T., Mori, N., Nakamura, M. et al. Atrophy of the lower limbs in elderly women: is it related to walking ability?. Eur J Appl Physiol 111, 989–995 (2011). https://doi.org/10.1007/s00421-010-1728-8
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DOI: https://doi.org/10.1007/s00421-010-1728-8