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Does the ACE I/D polymorphism, alone or in combination with the ACTN3 R577X polymorphism, influence muscle power phenotypes in young, non-athletic adults?

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Abstract

We investigated the association of the angiotensin converting enzyme gene (ACE) insertion/deletion (I/D) polymorphism, alone or in combination with the α-actinin-3 gene (ACTN3) R577X polymorphism, with jumping (vertical squat and counter-movement jump tests) and sprint ability (30 m dash) in non-athletic, healthy young adults [N = 281 (214 male), mean (SD) age 21 (2) years]. We did not observe any effect of the ACE I/D polymorphism on study phenotypes. We repeated the analyses separately in men and women and the results did not materially change. Likewise, the mean estimates of the study phenotypes were similar in subjects with the genotype combinations ACE II + ID and ACTN3 XX or ACE DD and ACTN3 RR + RX. We found no association between the ACE DD and ACTN3 RR + RX genotype combination and performance (≥90th of the sex-specific percentile). In summary, though the ACE I/D polymorphism is a strong candidate to modulate some exercise-related phenotypes or athletic performance status, this polymorphism, alone or in combination with the ACTN3 R577X polymorphism, does not seem to exert a major influence in the muscle ‘explosive’ power of young healthy adults, as assessed during multi-joint exercise tests.

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Acknowledgments

This study was funded by the Consejo Superior de Deportes (CSD, ref # UPR10/08), Fondo de Investigaciones Sanitarias (FIS, ref. # PS09/00194), and Swedish Council for Working Life and Social Research (FAS).

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Authors and Affiliations

  1. INEF, Universidad Politécnica de Madrid, Madrid, Spain

    Gabriel Rodríguez-Romo

  2. Department of Biosciences and Nutrition at NOVUM, Unit for Preventive Nutrition, Karolinska Institutet, Stockholm, Sweden

    Jonatan R. Ruiz

  3. Universidad Europea de Madrid, Villaviciosa de Odón, 28670, Madrid, Spain

    Catalina Santiago, Carmen Fiuza-Luces, Marta González-Freire, Félix Gómez-Gallego & Alejandro Lucia

  4. Centro de Investigación Hopsital 12 de Octubre and CIBERER, Madrid, Spain

    María Morán

Authors
  1. Gabriel Rodríguez-Romo
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  2. Jonatan R. Ruiz
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  3. Catalina Santiago
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  4. Carmen Fiuza-Luces
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  5. Marta González-Freire
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  6. Félix Gómez-Gallego
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  7. María Morán
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  8. Alejandro Lucia
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Corresponding author

Correspondence to Alejandro Lucia.

Additional information

Communicated by Narihiko Kondo.

M. Morán and A. Lucia contributed equally.

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Rodríguez-Romo, G., Ruiz, J.R., Santiago, C. et al. Does the ACE I/D polymorphism, alone or in combination with the ACTN3 R577X polymorphism, influence muscle power phenotypes in young, non-athletic adults?. Eur J Appl Physiol 110, 1099–1106 (2010). https://doi.org/10.1007/s00421-010-1608-2

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  • DOI: https://doi.org/10.1007/s00421-010-1608-2

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